Coexistence of t(15;17) and t(15;16;17) detected by fluorescence in situ hybridization in a patient with acute promyelocytic leukemia: A case report and literature review

Rui Zhang, Young Mi Kim, Xianfu Wang, Yan Li, Hui Pang, Ji-Yun Lee, Shibo Li

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current study presents the case of a 54-year-old female with APL carrying the atypical PML/RARA fusion signal due to a novel complex variant translocation t(15;16;17)(q22;q24;q21), as well as the classical PML/RARA fusion signal. Subsequent array comparative genomic hybridization revealed somatic, cryptic deletions on 3p25.3, 8q23.1 and 12p13.2-p13.1, and a duplication on 8q11.2; however, no genetic material loss or gain was observed in the breakpoint regions of chromosomes 15, 16 or17. To the best of our knowledge, this is the first report of the coexistence of two abnormal clones, one classical and one variant, presenting simultaneously in addition to cryptic chromosome segmental imbalances in an adult APL patient.

Original languageEnglish
Pages (from-to)1001-1008
Number of pages8
JournalOncology Letters
Volume8
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Acute Promyelocytic Leukemia
Fluorescence In Situ Hybridization
Leukemia
Genes
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 15
Retinoic Acid Receptors
Comparative Genomic Hybridization
Clone Cells
Chromosomes

Keywords

  • Acute promyelocytic leukemia
  • Array comparative genomic hybridization
  • Fluorescence in situ hybridization
  • Promyelocytic leukemia/retinoic acid α-receptor
  • Variant translocation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Coexistence of t(15;17) and t(15;16;17) detected by fluorescence in situ hybridization in a patient with acute promyelocytic leukemia : A case report and literature review. / Zhang, Rui; Kim, Young Mi; Wang, Xianfu; Li, Yan; Pang, Hui; Lee, Ji-Yun; Li, Shibo.

In: Oncology Letters, Vol. 8, No. 3, 01.01.2014, p. 1001-1008.

Research output: Contribution to journalArticle

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