Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice

Myung Goo Min, Dae-Jin Song, Marina Miller, Jae Youn Cho, Shauna McElwain, Paul Ferguson, David H. Broide

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Environmental tobacco smoke (ETS) can increase asthma symptoms and the frequency of asthma attacks. However, the contribution of ETS to airway remodeling in asthma is at present unknown. In this study, we have used a mouse model of allergen-induced airway remodeling to determine whether the combination of chronic exposure to ETS and chronic exposure to OVA allergen induces greater levels of airway remodeling than exposure to either chronic ETS or chronic OVA allergen alone. Mice exposed to chronic ETS alone did not develop significant eosinophilic airway iniammation, airway remodeling, or increased airway hyperreactivity to methacholine. In contrast, mice exposed to chronic OVA allergen had significantly increased levels of peribronchial fibrosis, increased thickening of the smooth muscle layer, increased mucus, and increased airway hyperreactivity which was significantly enhanced by coexposure to the combination of chronic ETS and chronic OVA allergen. Mice coesposed to chronic ETS and chronic OVA allergen had significantly increased levels of eotaxin-1 expression in airway epithelium which was associated with increased numbers of peribronchial eosinophils, as well as increased numbers of peribronchial cells expressing TGF-β1. These studies suggest that chronic coexposure to ETS significantly increases levels of allergen-induced airway remodeling (in particular smooth muscle thickness) and airway responsiveness by up-regulating expression of chemokines such as eotaxin-1 in airway epithelium with resultant recruitment of cells expressing TGF-β1 to the airway and enhanced airway remodeling.

Original languageEnglish
Pages (from-to)5321-5328
Number of pages8
JournalJournal of Immunology
Volume178
Issue number8
DOIs
Publication statusPublished - 2007 Apr 15

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Airway Remodeling
Smoke
Allergens
Tobacco
Chemokine CCL11
Asthma
Smooth Muscle
Epithelium
Methacholine Chloride
Environmental Exposure
Mucus
Chemokines
Eosinophils
Fibrosis
Cell Count

ASJC Scopus subject areas

  • Immunology

Cite this

Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice. / Min, Myung Goo; Song, Dae-Jin; Miller, Marina; Cho, Jae Youn; McElwain, Shauna; Ferguson, Paul; Broide, David H.

In: Journal of Immunology, Vol. 178, No. 8, 15.04.2007, p. 5321-5328.

Research output: Contribution to journalArticle

Min, Myung Goo ; Song, Dae-Jin ; Miller, Marina ; Cho, Jae Youn ; McElwain, Shauna ; Ferguson, Paul ; Broide, David H. / Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice. In: Journal of Immunology. 2007 ; Vol. 178, No. 8. pp. 5321-5328.
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