TY - JOUR
T1 - Coffee consumption and risk of fractures
T2 - A systematic review and dose-response meta-analysis
AU - Lee, Dong Ryul
AU - Lee, Jungun
AU - Rota, Matteo
AU - Lee, Juneyoung
AU - Ahn, Hyeong Sik
AU - Park, Sang Min
AU - Shin, Doosup
N1 - Funding Information:
This work was supported by Wonkwang University in 2013
PY - 2014/6
Y1 - 2014/6
N2 - Purpose: The data on the association between coffee consumption and the risk of fractures are inconclusive. We performed a comprehensive literature review and meta-analysis to better quantify this association. Methods: We identified all potentially relevant articles by searching MEDLINE, EMBASE, Cochrane Library, Web of Science, SCOPUS, and CINAHL (until February 2013). The keywords "coffee," "caffeine," "drink," and "beverage" were used as the exposure factors, and the keyword "fracture" was used as the outcome factor. We determined the overall relative risk (RR) and confidence interval (CI) for the highest and lowest levels of coffee consumption. A dose-response analysis was performed to assess the risk of fractures based on the level of coffee consumption. Results: We included 253,514 participants with 12,939 fracture cases from 9 cohort and 6 case-control studies. The estimated RR of fractures at the highest level of coffee consumption was 1.14 (95% CI: 1.05-1.24; I2=0.0%) in women and 0.76 (95% CI: 0.62-0.94; I2=7.3%) in men. In the dose-response analysis, the pooled RRs of fractures in women who consumed 2 and 8cups of coffee per day were 1.02 (95% CI: 1.01-1.04) and 1.54 (95% CI: 1.19-1.99), respectively. Conclusions: Our meta-analysis suggests that daily consumption of coffee is associated with an increased risk of fractures in women and a contrasting decreased risk in men. However, future well-designed studies should be performed to confirm these findings.
AB - Purpose: The data on the association between coffee consumption and the risk of fractures are inconclusive. We performed a comprehensive literature review and meta-analysis to better quantify this association. Methods: We identified all potentially relevant articles by searching MEDLINE, EMBASE, Cochrane Library, Web of Science, SCOPUS, and CINAHL (until February 2013). The keywords "coffee," "caffeine," "drink," and "beverage" were used as the exposure factors, and the keyword "fracture" was used as the outcome factor. We determined the overall relative risk (RR) and confidence interval (CI) for the highest and lowest levels of coffee consumption. A dose-response analysis was performed to assess the risk of fractures based on the level of coffee consumption. Results: We included 253,514 participants with 12,939 fracture cases from 9 cohort and 6 case-control studies. The estimated RR of fractures at the highest level of coffee consumption was 1.14 (95% CI: 1.05-1.24; I2=0.0%) in women and 0.76 (95% CI: 0.62-0.94; I2=7.3%) in men. In the dose-response analysis, the pooled RRs of fractures in women who consumed 2 and 8cups of coffee per day were 1.02 (95% CI: 1.01-1.04) and 1.54 (95% CI: 1.19-1.99), respectively. Conclusions: Our meta-analysis suggests that daily consumption of coffee is associated with an increased risk of fractures in women and a contrasting decreased risk in men. However, future well-designed studies should be performed to confirm these findings.
KW - Caffeine
KW - Coffee
KW - Dose-response relationship
KW - Fracture
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84896040305&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2014.02.007
DO - 10.1016/j.bone.2014.02.007
M3 - Article
C2 - 24576685
AN - SCOPUS:84896040305
VL - 63
SP - 20
EP - 28
JO - Bone
JF - Bone
SN - 8756-3282
ER -
