Cognitive deterioration and changes of P300 during total sleep deprivation

Heon-Jeong Lee, Leen Kim, Kwang Yoon Suh

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The study was conducted to evaluate the cognitive deteriorations induced by sleep deprivation with the computerized neurocognitive tests and the P300 event-related potential. Thirty healthy college students (22 men, eight women) participated in the present study. Subjects remained awake for 38 h under continuous surveillance. In the morning and the evening of the two study days, the computerized neurocognitive tests and the P300 were performed. In vigilance test and reaction unit test, there were significant cognitive impairments during sleep deprivation. However, in the cognitrone test there was significant functional improvement, which might be due to the practice effect. The P300 latency was significantly prolonged and the amplitudes decreased during sleep deprivation. The cognitive impairment during 38 h of sleep deprivation was mainly in terms of vigilance and reaction time. In contrast, higher complex cognitive function such as fine perceptual analyses, visual discrimination and working memory might be not affected by 38 h of total sleep deprivation. The changes of P300 were significantly correlated with the results of vigilance and reaction unit tests but not with the cognitrone test. Taken together, these results suggest that the P300 changes that occur during sleep deprivation are a reflection of the decrement in vigilance, which prolongs reaction time.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalPsychiatry and Clinical Neurosciences
Volume57
Issue number5
DOIs
Publication statusPublished - 2003 Oct 1

Fingerprint

Sleep Deprivation
Reaction Time
P300 Event-Related Potentials
Short-Term Memory
Cognition
Students

Keywords

  • Cognition
  • P300
  • Reaction time
  • Sleep deprivation
  • Vigilance

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Cognitive deterioration and changes of P300 during total sleep deprivation. / Lee, Heon-Jeong; Kim, Leen; Suh, Kwang Yoon.

In: Psychiatry and Clinical Neurosciences, Vol. 57, No. 5, 01.10.2003, p. 490-496.

Research output: Contribution to journalArticle

@article{c176aa7c459046b38fa3672cb1762d6a,
title = "Cognitive deterioration and changes of P300 during total sleep deprivation",
abstract = "The study was conducted to evaluate the cognitive deteriorations induced by sleep deprivation with the computerized neurocognitive tests and the P300 event-related potential. Thirty healthy college students (22 men, eight women) participated in the present study. Subjects remained awake for 38 h under continuous surveillance. In the morning and the evening of the two study days, the computerized neurocognitive tests and the P300 were performed. In vigilance test and reaction unit test, there were significant cognitive impairments during sleep deprivation. However, in the cognitrone test there was significant functional improvement, which might be due to the practice effect. The P300 latency was significantly prolonged and the amplitudes decreased during sleep deprivation. The cognitive impairment during 38 h of sleep deprivation was mainly in terms of vigilance and reaction time. In contrast, higher complex cognitive function such as fine perceptual analyses, visual discrimination and working memory might be not affected by 38 h of total sleep deprivation. The changes of P300 were significantly correlated with the results of vigilance and reaction unit tests but not with the cognitrone test. Taken together, these results suggest that the P300 changes that occur during sleep deprivation are a reflection of the decrement in vigilance, which prolongs reaction time.",
keywords = "Cognition, P300, Reaction time, Sleep deprivation, Vigilance",
author = "Heon-Jeong Lee and Leen Kim and Suh, {Kwang Yoon}",
year = "2003",
month = "10",
day = "1",
doi = "10.1046/j.1440-1819.2003.01153.x",
language = "English",
volume = "57",
pages = "490--496",
journal = "Psychiatry and Clinical Neurosciences",
issn = "1323-1316",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Cognitive deterioration and changes of P300 during total sleep deprivation

AU - Lee, Heon-Jeong

AU - Kim, Leen

AU - Suh, Kwang Yoon

PY - 2003/10/1

Y1 - 2003/10/1

N2 - The study was conducted to evaluate the cognitive deteriorations induced by sleep deprivation with the computerized neurocognitive tests and the P300 event-related potential. Thirty healthy college students (22 men, eight women) participated in the present study. Subjects remained awake for 38 h under continuous surveillance. In the morning and the evening of the two study days, the computerized neurocognitive tests and the P300 were performed. In vigilance test and reaction unit test, there were significant cognitive impairments during sleep deprivation. However, in the cognitrone test there was significant functional improvement, which might be due to the practice effect. The P300 latency was significantly prolonged and the amplitudes decreased during sleep deprivation. The cognitive impairment during 38 h of sleep deprivation was mainly in terms of vigilance and reaction time. In contrast, higher complex cognitive function such as fine perceptual analyses, visual discrimination and working memory might be not affected by 38 h of total sleep deprivation. The changes of P300 were significantly correlated with the results of vigilance and reaction unit tests but not with the cognitrone test. Taken together, these results suggest that the P300 changes that occur during sleep deprivation are a reflection of the decrement in vigilance, which prolongs reaction time.

AB - The study was conducted to evaluate the cognitive deteriorations induced by sleep deprivation with the computerized neurocognitive tests and the P300 event-related potential. Thirty healthy college students (22 men, eight women) participated in the present study. Subjects remained awake for 38 h under continuous surveillance. In the morning and the evening of the two study days, the computerized neurocognitive tests and the P300 were performed. In vigilance test and reaction unit test, there were significant cognitive impairments during sleep deprivation. However, in the cognitrone test there was significant functional improvement, which might be due to the practice effect. The P300 latency was significantly prolonged and the amplitudes decreased during sleep deprivation. The cognitive impairment during 38 h of sleep deprivation was mainly in terms of vigilance and reaction time. In contrast, higher complex cognitive function such as fine perceptual analyses, visual discrimination and working memory might be not affected by 38 h of total sleep deprivation. The changes of P300 were significantly correlated with the results of vigilance and reaction unit tests but not with the cognitrone test. Taken together, these results suggest that the P300 changes that occur during sleep deprivation are a reflection of the decrement in vigilance, which prolongs reaction time.

KW - Cognition

KW - P300

KW - Reaction time

KW - Sleep deprivation

KW - Vigilance

UR - http://www.scopus.com/inward/record.url?scp=0141893562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141893562&partnerID=8YFLogxK

U2 - 10.1046/j.1440-1819.2003.01153.x

DO - 10.1046/j.1440-1819.2003.01153.x

M3 - Article

C2 - 12950703

AN - SCOPUS:0141893562

VL - 57

SP - 490

EP - 496

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

SN - 1323-1316

IS - 5

ER -