Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

Ki Young Jung, Jae Wook Cho, Eun Yeon Joo, Sun Hwa Kim, Kyung Mook Choi, Juhee Chin, Kun Woo Park, Seung Bong Hong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

Original languageEnglish
Pages (from-to)1494-1501
Number of pages8
JournalClinical Neurophysiology
Volume121
Issue number9
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Electromagnetic Phenomena
Evoked Potentials
Tomography
Brain
Neuropsychological Tests
Epilepsy
topiramate
Pharmaceutical Preparations
Analysis of Variance
Electrodes
Therapeutics

Keywords

  • Cognitive function
  • Event-related potential (ERP)
  • Source localisation
  • Standardised low-resolution electromagnetic tomography (sLORETA)
  • Topiramate

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials. / Jung, Ki Young; Cho, Jae Wook; Joo, Eun Yeon; Kim, Sun Hwa; Choi, Kyung Mook; Chin, Juhee; Park, Kun Woo; Hong, Seung Bong.

In: Clinical Neurophysiology, Vol. 121, No. 9, 01.09.2010, p. 1494-1501.

Research output: Contribution to journalArticle

Jung, Ki Young ; Cho, Jae Wook ; Joo, Eun Yeon ; Kim, Sun Hwa ; Choi, Kyung Mook ; Chin, Juhee ; Park, Kun Woo ; Hong, Seung Bong. / Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials. In: Clinical Neurophysiology. 2010 ; Vol. 121, No. 9. pp. 1494-1501.
@article{cc69248cffb24a52a35a92ec1f210af5,
title = "Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials",
abstract = "Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.",
keywords = "Cognitive function, Event-related potential (ERP), Source localisation, Standardised low-resolution electromagnetic tomography (sLORETA), Topiramate",
author = "Jung, {Ki Young} and Cho, {Jae Wook} and Joo, {Eun Yeon} and Kim, {Sun Hwa} and Choi, {Kyung Mook} and Juhee Chin and Park, {Kun Woo} and Hong, {Seung Bong}",
year = "2010",
month = "9",
day = "1",
doi = "10.1016/j.clinph.2010.03.013",
language = "English",
volume = "121",
pages = "1494--1501",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "9",

}

TY - JOUR

T1 - Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

AU - Jung, Ki Young

AU - Cho, Jae Wook

AU - Joo, Eun Yeon

AU - Kim, Sun Hwa

AU - Choi, Kyung Mook

AU - Chin, Juhee

AU - Park, Kun Woo

AU - Hong, Seung Bong

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

AB - Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

KW - Cognitive function

KW - Event-related potential (ERP)

KW - Source localisation

KW - Standardised low-resolution electromagnetic tomography (sLORETA)

KW - Topiramate

UR - http://www.scopus.com/inward/record.url?scp=77955253764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955253764&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2010.03.013

DO - 10.1016/j.clinph.2010.03.013

M3 - Article

VL - 121

SP - 1494

EP - 1501

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 9

ER -