Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

Ki Young Jung, Jae Wook Cho, Eun Yeon Joo, Sun Hwa Kim, Kyung Mook Choi, Juhee Chin, Kun Woo Park, Seung Bong Hong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

Original languageEnglish
Pages (from-to)1494-1501
Number of pages8
JournalClinical Neurophysiology
Volume121
Issue number9
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • Cognitive function
  • Event-related potential (ERP)
  • Source localisation
  • Standardised low-resolution electromagnetic tomography (sLORETA)
  • Topiramate

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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