Abstract
Objective This study was conducted to investigate the cognitive factors that can longitudinally predict the response to treatment in patients with schizophrenia. Methods The subjects were 49 patients with schizophrenia who were newly hospitalized in an acute psychiatry ward and had not been treated with medication for at least 8 weeks prior to the study. The symptoms and cognitive functions of the patients were evaluated at baseline before treatment (T0), at eight weeks after treatment (T1), and one year after treatment (T2). Clinical symptoms were assessed using the PANSS, and cognitive functions were estimated using the Vigilance Test, Cognitrone Test, Wisconsin Card Sorting Test (WCST), and the Korean version of the Memory Assessment Scales (K-MAS). Results The patient group showed marked impairments in cognitive function when compared to the normal group, but the patients' clinical symptoms and cognitive functions improved after drug treatment. The patients also showed consistent improvement in verbal and nonverbal memory function as time progressed. Furthermore, there was a significant correlation between clinical symptoms and cognitive functions in the patient group. The cognitive variables that best predicted treatment response and prognosis were total errors on the WCST and immediate list recall component of the K-MAS. It was also shown that the number of total errors on the WCST was a better cognitive predictor than the number of errors in immediate recall. Conclusion The results of the present study show that the neurocognitive functions of patients with schizophrenia can be stabilized with treatment intervention, that treatment response is related to improvement in cognitive function, and that cognitive domains, especially executive function, can predict treatment response and prognosis in patients with schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 106-114 |
| Number of pages | 9 |
| Journal | Psychiatry Investigation |
| Volume | 5 |
| Issue number | 2 |
| Publication status | Published - 2008 Jun 1 |
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Keywords
- Cognition
- Predictor
- Prognosis
- Schizophrenia
- Treatment response
- Wisconsin card sorting test
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Cognitive factors for predicting treatment response in schizophrenic patients : One-year follow-up study. / Kim, Yong Ku; Lee, Ae Ra; Hur, Ji Won; Yoon, Ho-Kyoung; Lee, Bun Hee; Ko, Young-Hoon.
In: Psychiatry Investigation, Vol. 5, No. 2, 01.06.2008, p. 106-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cognitive factors for predicting treatment response in schizophrenic patients
T2 - One-year follow-up study
AU - Kim, Yong Ku
AU - Lee, Ae Ra
AU - Hur, Ji Won
AU - Yoon, Ho-Kyoung
AU - Lee, Bun Hee
AU - Ko, Young-Hoon
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Objective This study was conducted to investigate the cognitive factors that can longitudinally predict the response to treatment in patients with schizophrenia. Methods The subjects were 49 patients with schizophrenia who were newly hospitalized in an acute psychiatry ward and had not been treated with medication for at least 8 weeks prior to the study. The symptoms and cognitive functions of the patients were evaluated at baseline before treatment (T0), at eight weeks after treatment (T1), and one year after treatment (T2). Clinical symptoms were assessed using the PANSS, and cognitive functions were estimated using the Vigilance Test, Cognitrone Test, Wisconsin Card Sorting Test (WCST), and the Korean version of the Memory Assessment Scales (K-MAS). Results The patient group showed marked impairments in cognitive function when compared to the normal group, but the patients' clinical symptoms and cognitive functions improved after drug treatment. The patients also showed consistent improvement in verbal and nonverbal memory function as time progressed. Furthermore, there was a significant correlation between clinical symptoms and cognitive functions in the patient group. The cognitive variables that best predicted treatment response and prognosis were total errors on the WCST and immediate list recall component of the K-MAS. It was also shown that the number of total errors on the WCST was a better cognitive predictor than the number of errors in immediate recall. Conclusion The results of the present study show that the neurocognitive functions of patients with schizophrenia can be stabilized with treatment intervention, that treatment response is related to improvement in cognitive function, and that cognitive domains, especially executive function, can predict treatment response and prognosis in patients with schizophrenia.
AB - Objective This study was conducted to investigate the cognitive factors that can longitudinally predict the response to treatment in patients with schizophrenia. Methods The subjects were 49 patients with schizophrenia who were newly hospitalized in an acute psychiatry ward and had not been treated with medication for at least 8 weeks prior to the study. The symptoms and cognitive functions of the patients were evaluated at baseline before treatment (T0), at eight weeks after treatment (T1), and one year after treatment (T2). Clinical symptoms were assessed using the PANSS, and cognitive functions were estimated using the Vigilance Test, Cognitrone Test, Wisconsin Card Sorting Test (WCST), and the Korean version of the Memory Assessment Scales (K-MAS). Results The patient group showed marked impairments in cognitive function when compared to the normal group, but the patients' clinical symptoms and cognitive functions improved after drug treatment. The patients also showed consistent improvement in verbal and nonverbal memory function as time progressed. Furthermore, there was a significant correlation between clinical symptoms and cognitive functions in the patient group. The cognitive variables that best predicted treatment response and prognosis were total errors on the WCST and immediate list recall component of the K-MAS. It was also shown that the number of total errors on the WCST was a better cognitive predictor than the number of errors in immediate recall. Conclusion The results of the present study show that the neurocognitive functions of patients with schizophrenia can be stabilized with treatment intervention, that treatment response is related to improvement in cognitive function, and that cognitive domains, especially executive function, can predict treatment response and prognosis in patients with schizophrenia.
KW - Cognition
KW - Predictor
KW - Prognosis
KW - Schizophrenia
KW - Treatment response
KW - Wisconsin card sorting test
UR - http://www.scopus.com/inward/record.url?scp=46949091359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46949091359&partnerID=8YFLogxK
M3 - Article
VL - 5
SP - 106
EP - 114
JO - Psychiatry Investigation
JF - Psychiatry Investigation
SN - 1738-3684
IS - 2
ER -