Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease: Association between allergic airway disease and irritable bowel syndrome

Sanghyun Kim, Bora Keum, Junhyoung Byun, Byoungjae Kim, Kijeong Lee, Jiwoo Yeon, Jae Min Lee, Hyuk Soon Choi, Eun-Sun Kim, Yoon Tae Jeen, Hong Sik Lee, Hoonjai Chun, Taehoon Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.

Original languageEnglish
Article number181
JournalInternational journal of molecular sciences
Volume23
Issue number1
DOIs
Publication statusPublished - 2022 Jan 1

Keywords

  • Allergic airway diseases
  • Irritable bowel syndrome
  • Mast cells
  • Salbutamol

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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