TY - JOUR
T1 - Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease
T2 - Association between allergic airway disease and irritable bowel syndrome
AU - Kim, Sanghyun
AU - Keum, Bora
AU - Byun, Junhyoung
AU - Kim, Byoungjae
AU - Lee, Kijeong
AU - Yeon, Jiwoo
AU - Lee, Jaemin
AU - Choi, Hyuksoon
AU - Kim, Eunsun
AU - Jeen, Yoontae
AU - Lee, Hongsik
AU - Chun, Hoonjai
AU - Kim, Taehoon
N1 - Funding Information:
Funding: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and Ministry of Science, ICT and Future Planning, grant number NRF-2020R1A2C1006398; the Ministry of Science and ICT (MSIT), Korea, under the ICT Creative Consilience program, grant number IITP-2021-0-01819, supervised by the Institute for Information & communications Technology Planning & Evaluation (IITP). This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O2106591).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.
AB - Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.
KW - Allergic airway diseases
KW - Irritable bowel syndrome
KW - Mast cells
KW - Salbutamol
UR - http://www.scopus.com/inward/record.url?scp=85121585701&partnerID=8YFLogxK
U2 - 10.3390/ijms23010181
DO - 10.3390/ijms23010181
M3 - Article
C2 - 35008607
AN - SCOPUS:85121585701
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 1
M1 - 181
ER -