Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles

Jae-Seung Lee, Min Su Han, Chad A. Mirkin

Research output: Contribution to journalArticle

1022 Citations (Scopus)


Color is everything: Hg2+ in aqueous media is detected by the formation of thymidine-Hg2+-thymidine coordination complexes, which raises the melting temperature of the DNA-hybridized gold nanoparticle probes and thus the temperature at which the probes disperse and effect a purple-to-red color change. The method has very high sensitivity and selectivity, and it provides a simple and fast colorimetric readout (see picture). (Figure Presented)

Original languageEnglish
Pages (from-to)4093-4096
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number22
Publication statusPublished - 2007 Jun 27
Externally publishedYes



  • Colorimetric detection
  • DNA
  • Mercury
  • Nanoparticles
  • Sensors

ASJC Scopus subject areas

  • Chemistry(all)

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