Colorimetric SNP Genotyping Based on Allele-Specific PCR by Using a Thiol-Labeled Primer

Ye Lim Jung, Cheulhee Jung, Harshala Parab, Dae Yeon Cho, Hyun Gyu Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Red gold/blue gold: A highly convenient colorimetric method for the identification of single-nucleotide polymorphism was developed by utilizing gold nanoparticles and an allele-specific polymerase chain reaction. Its diagnostic capability was successfully demonstrated by correctly identifying various mutations in the BRCA1 gene.

Original languageEnglish
Pages (from-to)1387-1390
Number of pages4
JournalChemBioChem
Volume12
Issue number9
DOIs
Publication statusPublished - 2011 Jun 14

Keywords

  • BRCA
  • Gold
  • Nanoparticles
  • Polymerase chain reaction
  • Single nucleotide polymorphism
  • Thiolated primer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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