Combination of anxiety and depression is associated with an increased headache frequency in migraineurs: A population-based study

Kyungmi Oh, Soo Jin Cho, Yun Kyung Chung, Jae Moon Kim, Min Kyung Chu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Although anxiety and depression have been classified as distinct traits of affective disorders, previous studies have reported their co-occurrence in subjects with migraine. However, few reports are available on the clinical implications of this comorbidity. This study is to assess the comorbidity of anxiety and depression in subjects with migraine and its clinical implications in a population-based sample from Korea. Methods: We selected Korean subjects aged 19-69 years by the stratified random sampling method, and evaluated them using a semi-structured interview, designed to identify headache type, anxiety, and depression. We used Goldberg Anxiety Scale questions and Patient Health Questionnnaire-9 for the diagnosis of anxiety and depression, respectively. Results: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year. Among these 147 subjects, 17 (11.6%) had anxiety and depression, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 93 (63.3%) had neither anxiety nor depression. Headache frequency per month was remarkably higher in subjects having migraine with anxiety and depression (median [25-75 percentile values], 8.0 [2.5-21.0]) than in those having migraine with anxiety alone (2.0 [1.0-5.0], = 0.003), migraine with depression alone (1.0 [0.3-4.0], = 0.001), and migraine without anxiety or depression (1.0 [0.3-3.0], < 0.001). The migraine with anxiety alone (7.0 [6.0-8.0], = 0.011) group and migraine with anxiety and depression (7.0 [5.0-9.0], = 0.018) group showed higher Visual Analogue Scale scores for pain intensity compare to migraine without anxiety or depression (6.0 [5.0-7.0]) group. Conclusions: Approximately 1/3 of migraineurs with anxiety had depression and 2/3 of migraineurs with depression had anxiety. Combination of anxiety and depression was associated with an increased headache frequency. Anxiety was associated with exacerbation of headache intensity.

Original languageEnglish
Article number238
JournalBMC Neurology
Volume14
Issue number1
DOIs
Publication statusPublished - 2014 Dec 14

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Headache
Anxiety
Depression
Migraine Disorders
Population
Comorbidity
Interviews
Pain Measurement
Korea
Mood Disorders

Keywords

  • Anxiety
  • Comorbidity
  • Depression
  • Epidemiology
  • Migraine

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Combination of anxiety and depression is associated with an increased headache frequency in migraineurs : A population-based study. / Oh, Kyungmi; Cho, Soo Jin; Chung, Yun Kyung; Kim, Jae Moon; Chu, Min Kyung.

In: BMC Neurology, Vol. 14, No. 1, 238, 14.12.2014.

Research output: Contribution to journalArticle

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abstract = "Background: Although anxiety and depression have been classified as distinct traits of affective disorders, previous studies have reported their co-occurrence in subjects with migraine. However, few reports are available on the clinical implications of this comorbidity. This study is to assess the comorbidity of anxiety and depression in subjects with migraine and its clinical implications in a population-based sample from Korea. Methods: We selected Korean subjects aged 19-69 years by the stratified random sampling method, and evaluated them using a semi-structured interview, designed to identify headache type, anxiety, and depression. We used Goldberg Anxiety Scale questions and Patient Health Questionnnaire-9 for the diagnosis of anxiety and depression, respectively. Results: Of the 2,762 participants who completed the interview, 147 subjects (5.4{\%}) were classified as having a migraine during the previous year. Among these 147 subjects, 17 (11.6{\%}) had anxiety and depression, 28 (19.0{\%}) had anxiety alone, 9 (6.1{\%}) had depression alone, and 93 (63.3{\%}) had neither anxiety nor depression. Headache frequency per month was remarkably higher in subjects having migraine with anxiety and depression (median [25-75 percentile values], 8.0 [2.5-21.0]) than in those having migraine with anxiety alone (2.0 [1.0-5.0], = 0.003), migraine with depression alone (1.0 [0.3-4.0], = 0.001), and migraine without anxiety or depression (1.0 [0.3-3.0], < 0.001). The migraine with anxiety alone (7.0 [6.0-8.0], = 0.011) group and migraine with anxiety and depression (7.0 [5.0-9.0], = 0.018) group showed higher Visual Analogue Scale scores for pain intensity compare to migraine without anxiety or depression (6.0 [5.0-7.0]) group. Conclusions: Approximately 1/3 of migraineurs with anxiety had depression and 2/3 of migraineurs with depression had anxiety. Combination of anxiety and depression was associated with an increased headache frequency. Anxiety was associated with exacerbation of headache intensity.",
keywords = "Anxiety, Comorbidity, Depression, Epidemiology, Migraine",
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AU - Kim, Jae Moon

AU - Chu, Min Kyung

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N2 - Background: Although anxiety and depression have been classified as distinct traits of affective disorders, previous studies have reported their co-occurrence in subjects with migraine. However, few reports are available on the clinical implications of this comorbidity. This study is to assess the comorbidity of anxiety and depression in subjects with migraine and its clinical implications in a population-based sample from Korea. Methods: We selected Korean subjects aged 19-69 years by the stratified random sampling method, and evaluated them using a semi-structured interview, designed to identify headache type, anxiety, and depression. We used Goldberg Anxiety Scale questions and Patient Health Questionnnaire-9 for the diagnosis of anxiety and depression, respectively. Results: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year. Among these 147 subjects, 17 (11.6%) had anxiety and depression, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 93 (63.3%) had neither anxiety nor depression. Headache frequency per month was remarkably higher in subjects having migraine with anxiety and depression (median [25-75 percentile values], 8.0 [2.5-21.0]) than in those having migraine with anxiety alone (2.0 [1.0-5.0], = 0.003), migraine with depression alone (1.0 [0.3-4.0], = 0.001), and migraine without anxiety or depression (1.0 [0.3-3.0], < 0.001). The migraine with anxiety alone (7.0 [6.0-8.0], = 0.011) group and migraine with anxiety and depression (7.0 [5.0-9.0], = 0.018) group showed higher Visual Analogue Scale scores for pain intensity compare to migraine without anxiety or depression (6.0 [5.0-7.0]) group. Conclusions: Approximately 1/3 of migraineurs with anxiety had depression and 2/3 of migraineurs with depression had anxiety. Combination of anxiety and depression was associated with an increased headache frequency. Anxiety was associated with exacerbation of headache intensity.

AB - Background: Although anxiety and depression have been classified as distinct traits of affective disorders, previous studies have reported their co-occurrence in subjects with migraine. However, few reports are available on the clinical implications of this comorbidity. This study is to assess the comorbidity of anxiety and depression in subjects with migraine and its clinical implications in a population-based sample from Korea. Methods: We selected Korean subjects aged 19-69 years by the stratified random sampling method, and evaluated them using a semi-structured interview, designed to identify headache type, anxiety, and depression. We used Goldberg Anxiety Scale questions and Patient Health Questionnnaire-9 for the diagnosis of anxiety and depression, respectively. Results: Of the 2,762 participants who completed the interview, 147 subjects (5.4%) were classified as having a migraine during the previous year. Among these 147 subjects, 17 (11.6%) had anxiety and depression, 28 (19.0%) had anxiety alone, 9 (6.1%) had depression alone, and 93 (63.3%) had neither anxiety nor depression. Headache frequency per month was remarkably higher in subjects having migraine with anxiety and depression (median [25-75 percentile values], 8.0 [2.5-21.0]) than in those having migraine with anxiety alone (2.0 [1.0-5.0], = 0.003), migraine with depression alone (1.0 [0.3-4.0], = 0.001), and migraine without anxiety or depression (1.0 [0.3-3.0], < 0.001). The migraine with anxiety alone (7.0 [6.0-8.0], = 0.011) group and migraine with anxiety and depression (7.0 [5.0-9.0], = 0.018) group showed higher Visual Analogue Scale scores for pain intensity compare to migraine without anxiety or depression (6.0 [5.0-7.0]) group. Conclusions: Approximately 1/3 of migraineurs with anxiety had depression and 2/3 of migraineurs with depression had anxiety. Combination of anxiety and depression was associated with an increased headache frequency. Anxiety was associated with exacerbation of headache intensity.

KW - Anxiety

KW - Comorbidity

KW - Depression

KW - Epidemiology

KW - Migraine

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