Abstract
We describe a promising non-invasive transdermal delivery system comprising block copolymer composite micelles that contained a phase-change material (PCM), photothermal Au nanoparticles (AuNPs), and hydrophobic drugs in the core. To minimize cell toxicity, we developed block copolymer micelles with a poly(e{open}-caprolactone) (PCL) biodegradable core and a hyperbranched polyglycol (hbPG) shell. The hbPG block formed micelles at a low-molecular-weight fraction of a low-molecular-weight block copolymer. The composite micelles showed excellent biocompatibility with cell viability at high concentrations. Visible light irradiation (λ=520nm) of the composite micelles induced the photothermal effects of the AuNPs and melting of the PCM (lauric acid); hence, the drugs were released along with the PCM liquid. The release rate was controlled by the light intensity. Based on in vitro and in vivo skin penetration studies, the skin permeability of the drug remarkably improved under mild light irradiation (18J/cm2) that was much lower than the dose that causes skin damage.
| Original language | English |
|---|---|
| Pages (from-to) | 324-331 |
| Number of pages | 8 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume | 135 |
| DOIs | |
| Publication status | Published - 2015 Nov 1 |
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Keywords
- Au nanoparticles
- Block copolymer micelle
- Phase changing materials
- Photothermal effect
- Transdermal delivery
ASJC Scopus subject areas
- Biotechnology
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry
Cite this
Combination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugs. / Kim, Yong Jin; Kim, Bongsoo; Kim, Jin Woong; Nam, Gaewon; Jang, Hyon Seok; Kang, Sun woong; Jeong, Unyong.
In: Colloids and Surfaces B: Biointerfaces, Vol. 135, 01.11.2015, p. 324-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugs
AU - Kim, Yong Jin
AU - Kim, Bongsoo
AU - Kim, Jin Woong
AU - Nam, Gaewon
AU - Jang, Hyon Seok
AU - Kang, Sun woong
AU - Jeong, Unyong
PY - 2015/11/1
Y1 - 2015/11/1
N2 - We describe a promising non-invasive transdermal delivery system comprising block copolymer composite micelles that contained a phase-change material (PCM), photothermal Au nanoparticles (AuNPs), and hydrophobic drugs in the core. To minimize cell toxicity, we developed block copolymer micelles with a poly(e{open}-caprolactone) (PCL) biodegradable core and a hyperbranched polyglycol (hbPG) shell. The hbPG block formed micelles at a low-molecular-weight fraction of a low-molecular-weight block copolymer. The composite micelles showed excellent biocompatibility with cell viability at high concentrations. Visible light irradiation (λ=520nm) of the composite micelles induced the photothermal effects of the AuNPs and melting of the PCM (lauric acid); hence, the drugs were released along with the PCM liquid. The release rate was controlled by the light intensity. Based on in vitro and in vivo skin penetration studies, the skin permeability of the drug remarkably improved under mild light irradiation (18J/cm2) that was much lower than the dose that causes skin damage.
AB - We describe a promising non-invasive transdermal delivery system comprising block copolymer composite micelles that contained a phase-change material (PCM), photothermal Au nanoparticles (AuNPs), and hydrophobic drugs in the core. To minimize cell toxicity, we developed block copolymer micelles with a poly(e{open}-caprolactone) (PCL) biodegradable core and a hyperbranched polyglycol (hbPG) shell. The hbPG block formed micelles at a low-molecular-weight fraction of a low-molecular-weight block copolymer. The composite micelles showed excellent biocompatibility with cell viability at high concentrations. Visible light irradiation (λ=520nm) of the composite micelles induced the photothermal effects of the AuNPs and melting of the PCM (lauric acid); hence, the drugs were released along with the PCM liquid. The release rate was controlled by the light intensity. Based on in vitro and in vivo skin penetration studies, the skin permeability of the drug remarkably improved under mild light irradiation (18J/cm2) that was much lower than the dose that causes skin damage.
KW - Au nanoparticles
KW - Block copolymer micelle
KW - Phase changing materials
KW - Photothermal effect
KW - Transdermal delivery
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UR - http://www.scopus.com/inward/citedby.url?scp=84939456643&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2015.07.061
DO - 10.1016/j.colsurfb.2015.07.061
M3 - Article
VL - 135
SP - 324
EP - 331
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
SN - 0927-7765
ER -