Combination of statin and ezetimibe versus statin monotherapy on cardiovascular disease and type 2 diabetes incidence among adults with impaired fasting glucose: A propensity-matched nationwide cohort study

You Bin Lee, Bongsung Kim, Kyungdo Han, Jung A. Kim, Eun Roh, So Hyeon Hong, Kyung Mook Choi, Sei-Hyun Baik, Hye Jin Yoo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: We investigated the effects of statin-ezetimibe combination therapy compared with statin-only treatment on the hazard of incident type 2 diabetes (T2D), myocardial infarction (MI), and stroke among adults with impaired fasting glucose (IFG) in a real-world setting. Methods: The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this propensity-matched nationwide cohort study. Among 56,633 IFG patients without baseline cardiovascular disease (CVD) and/or T2D who initiated statin therapy with or without ezetimibe, 1,155 with statin-ezetimibe combination therapy were matched based on a propensity score at a 1:5 ratio with 5,775 patients who received statin monotherapy. The hazards of T2D, MI, and stroke were compared between these treatment groups. Results: The incidence rate per 1,000 person-years was 19.62 (statin monotherapy group) and 21.02 (combined treatment group) for T2D, 1.53 (statin monotherapy group) and 1.70 (combined treatment group) for MI, and 1.99 (statin monotherapy group) and 2.06 (combined treatment group) for stroke. The hazards of T2D, MI, and stroke were not significantly different between the statin monotherapy group and the statin-ezetimibe combination therapy group. Conclusion: The combination of ezetimibe in addition to statin treatment was not associated with a significantly different risk of T2D and CVDs compared with statin monotherapy in Korean adults with IFG.

Original languageEnglish
Pages (from-to)303-312
Number of pages10
JournalJournal of Lipid and Atherosclerosis
Volume10
Issue number3
DOIs
Publication statusPublished - 2021 Sep

Keywords

  • Cardiovascular diseases
  • Ezetimibe
  • Prediabetic state
  • Statin
  • Type 2 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Fingerprint

Dive into the research topics of 'Combination of statin and ezetimibe versus statin monotherapy on cardiovascular disease and type 2 diabetes incidence among adults with impaired fasting glucose: A propensity-matched nationwide cohort study'. Together they form a unique fingerprint.

Cite this