Combination therapy with BMP-2 and BMSCs enhances bone healing efficacy of PCL scaffold fabricated using the 3D plotting system in a large segmental defect model

Sun Woong Kang, Ji Hoon Bae, Su A. Park, Wan Doo Kim, Mi Su Park, You Jin Ko, Hyon Seok Jang, Jung Ho Park

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The three-dimensional (3D) plotting system is a rapidly-developing scaffold fabrication method for bone tissue engineering. It yields a highly porous and inter-connective structure without the use of cytotoxic solvents. However, the therapeutic effects of a scaffold fabricated using the 3D plotting system in a large segmental defect model have not yet been demonstrated. We have tested two hypotheses: whether the bone healing efficacy of scaffold fabricated using the 3D plotting system would be enhanced by bone marrow-derived mesenchymal stem cell (BMSC) transplantation; and whether the combination of bone morphogenetic protein-2 (BMP-2) administration and BMSC transplantation onto the scaffold would act synergistically to enhance bone regeneration in a large segmental defect model. The use of the combined therapy did increase bone regeneration further as compared to that with monotherapy in large segmental bone defects.

Original languageEnglish
Pages (from-to)1375-1384
Number of pages10
JournalBiotechnology letters
Volume34
Issue number7
DOIs
Publication statusPublished - 2012 Jul

Keywords

  • 3D plotting system
  • Bone marrow-derived mesenchymal stem cells
  • Bone morphogenetic protein-2
  • Bone tissue engineering
  • Polycaprolactone scaffold

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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