Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.
|Number of pages||6|
|Journal||Combinatorial Chemistry and High Throughput Screening|
|Publication status||Published - 2016 Jun 1|
- Combinatorial chemistry
- Dansyl chloride
- PH sensor.
ASJC Scopus subject areas
- Drug Discovery
- Computer Science Applications
- Organic Chemistry