Combinatorial dansyl library and its applications to pH-responsive probes

Seong Cheol Hong, Dhiraj P. Murale, Jun Seok Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalCombinatorial Chemistry and High Throughput Screening
Volume19
Issue number5
DOIs
Publication statusPublished - 2016 Jun 1
Externally publishedYes

Keywords

  • Combinatorial chemistry
  • Dansyl chloride
  • PH sensor.

ASJC Scopus subject areas

  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Combinatorial dansyl library and its applications to pH-responsive probes'. Together they form a unique fingerprint.

Cite this