Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder

Jiyoon Jung, Yang Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong Sik Kim, Young Dong Yu, Joo Young Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3 × 4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalJournal of Pathology and Translational Medicine
Volume52
Issue number2
DOIs
Publication statusPublished - 2018 Mar 1

Keywords

  • Adenosquamous
  • Carcinoma
  • Gallbladder
  • Large cell neuroendocrine carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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  • Cite this

    Jung, J., Chae, Y. S., Kim, C. H., Lee, Y., Lee, J. H., Kim, D. S., Yu, Y. D., & Kim, J. Y. (2018). Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder. Journal of Pathology and Translational Medicine, 52(2), 121-125. https://doi.org/10.4132/jptm.2017.08.20