Abstract
Background & aims Several food groups or dietary factors and the cervical microbiota may be involved in cervical carcinogenesis, but the evidence is not clear yet. We aimed to assess the association between dietary pattern and cervical intraepithelial neoplasia (CIN) and the combined effect of dietary pattern and cervical microbiome on the risk of CIN. Methods The cervical microbiota and diet assessed by pyrosequencing and a food-frequency questionnaire, respectively, of 65 women with CIN and 72 control women were used in this study. Principal component analysis and cluster analysis were used to identify dietary patterns and microbiome community types, respectively. The association between dietary pattern and CIN risk was assessed using multivariable logistic regression analysis. The combined effect of dietary pattern and microbiome on CIN risk was determined using relative excess risk due to interaction (RERI) and synergy index (S). Results Two dietary patterns and four community types were identified: prudent diet characterized by higher intake of vegetables and fishes; semi-Western diet characterized by higher intake of bread, dairy products, eggs, and soft drinks and relatively higher fat intake ratio; and Lactobacillus crispatus–, L. iners–, Atopobium vaginae–, and Prevotella bivia–dominant types. The high-scoring group of participants with a semi-Western diet had a higher risk of CIN (odds ratio [OR] 3.44, 95% confidence interval [CI] 1.11–10.7, p = 0.03), compared with the low or medium-scoring group of those with a semi-Western diet. L. iners–dominant (OR 6.39, 95% CI 1.52–26.7, p = 0.01) and A. vaginae–dominant (OR 4.99, 95% CI 1.17–21.3, p = 0.03) dominant types had a higher risk of CIN, compared with the L. crispatus–dominant type. The synergistic effect of semi-Western diet and A. vaginae–dominant type on CIN risk was observed (OR 20.8, 95% CI 2.21–195.6, p = 0.01, RERI/S 9.64/1.96). Conclusions Our findings suggest that semi-Western diet and its combination with A. vaginae–dominant microflora may represent an important risk factor for cervical neoplasia.
| Original language | English |
|---|---|
| Pages (from-to) | 1434-1441 |
| Number of pages | 8 |
| Journal | Clinical Nutrition |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 Dec 1 |
Fingerprint
Keywords
- Cervical intraepithelial neoplasia
- Dietary pattern
- Microbiome
- Pyrosequencing
- South Korea
ASJC Scopus subject areas
- Nutrition and Dietetics
- Critical Care and Intensive Care Medicine
Cite this
Combined effect of diet and cervical microbiome on the risk of cervical intraepithelial neoplasia. / Seo, Sang Soo; Oh, Hea Young; Lee, Jae Kwan; Kong, Ji Sook; Lee, Dong Ock; Kim, Mi Kyung.
In: Clinical Nutrition, Vol. 35, No. 6, 01.12.2016, p. 1434-1441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combined effect of diet and cervical microbiome on the risk of cervical intraepithelial neoplasia
AU - Seo, Sang Soo
AU - Oh, Hea Young
AU - Lee, Jae Kwan
AU - Kong, Ji Sook
AU - Lee, Dong Ock
AU - Kim, Mi Kyung
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background & aims Several food groups or dietary factors and the cervical microbiota may be involved in cervical carcinogenesis, but the evidence is not clear yet. We aimed to assess the association between dietary pattern and cervical intraepithelial neoplasia (CIN) and the combined effect of dietary pattern and cervical microbiome on the risk of CIN. Methods The cervical microbiota and diet assessed by pyrosequencing and a food-frequency questionnaire, respectively, of 65 women with CIN and 72 control women were used in this study. Principal component analysis and cluster analysis were used to identify dietary patterns and microbiome community types, respectively. The association between dietary pattern and CIN risk was assessed using multivariable logistic regression analysis. The combined effect of dietary pattern and microbiome on CIN risk was determined using relative excess risk due to interaction (RERI) and synergy index (S). Results Two dietary patterns and four community types were identified: prudent diet characterized by higher intake of vegetables and fishes; semi-Western diet characterized by higher intake of bread, dairy products, eggs, and soft drinks and relatively higher fat intake ratio; and Lactobacillus crispatus–, L. iners–, Atopobium vaginae–, and Prevotella bivia–dominant types. The high-scoring group of participants with a semi-Western diet had a higher risk of CIN (odds ratio [OR] 3.44, 95% confidence interval [CI] 1.11–10.7, p = 0.03), compared with the low or medium-scoring group of those with a semi-Western diet. L. iners–dominant (OR 6.39, 95% CI 1.52–26.7, p = 0.01) and A. vaginae–dominant (OR 4.99, 95% CI 1.17–21.3, p = 0.03) dominant types had a higher risk of CIN, compared with the L. crispatus–dominant type. The synergistic effect of semi-Western diet and A. vaginae–dominant type on CIN risk was observed (OR 20.8, 95% CI 2.21–195.6, p = 0.01, RERI/S 9.64/1.96). Conclusions Our findings suggest that semi-Western diet and its combination with A. vaginae–dominant microflora may represent an important risk factor for cervical neoplasia.
AB - Background & aims Several food groups or dietary factors and the cervical microbiota may be involved in cervical carcinogenesis, but the evidence is not clear yet. We aimed to assess the association between dietary pattern and cervical intraepithelial neoplasia (CIN) and the combined effect of dietary pattern and cervical microbiome on the risk of CIN. Methods The cervical microbiota and diet assessed by pyrosequencing and a food-frequency questionnaire, respectively, of 65 women with CIN and 72 control women were used in this study. Principal component analysis and cluster analysis were used to identify dietary patterns and microbiome community types, respectively. The association between dietary pattern and CIN risk was assessed using multivariable logistic regression analysis. The combined effect of dietary pattern and microbiome on CIN risk was determined using relative excess risk due to interaction (RERI) and synergy index (S). Results Two dietary patterns and four community types were identified: prudent diet characterized by higher intake of vegetables and fishes; semi-Western diet characterized by higher intake of bread, dairy products, eggs, and soft drinks and relatively higher fat intake ratio; and Lactobacillus crispatus–, L. iners–, Atopobium vaginae–, and Prevotella bivia–dominant types. The high-scoring group of participants with a semi-Western diet had a higher risk of CIN (odds ratio [OR] 3.44, 95% confidence interval [CI] 1.11–10.7, p = 0.03), compared with the low or medium-scoring group of those with a semi-Western diet. L. iners–dominant (OR 6.39, 95% CI 1.52–26.7, p = 0.01) and A. vaginae–dominant (OR 4.99, 95% CI 1.17–21.3, p = 0.03) dominant types had a higher risk of CIN, compared with the L. crispatus–dominant type. The synergistic effect of semi-Western diet and A. vaginae–dominant type on CIN risk was observed (OR 20.8, 95% CI 2.21–195.6, p = 0.01, RERI/S 9.64/1.96). Conclusions Our findings suggest that semi-Western diet and its combination with A. vaginae–dominant microflora may represent an important risk factor for cervical neoplasia.
KW - Cervical intraepithelial neoplasia
KW - Dietary pattern
KW - Microbiome
KW - Pyrosequencing
KW - South Korea
UR - http://www.scopus.com/inward/record.url?scp=84962694925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962694925&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2016.03.019
DO - 10.1016/j.clnu.2016.03.019
M3 - Article
C2 - 27075319
AN - SCOPUS:84962694925
VL - 35
SP - 1434
EP - 1441
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 6
ER -