Combined effect of high-normal blood pressure and low HDL cholesterol on mortality in an elderly Korean Population

The South-West Seoul (SWS) Study

Nan Hee Kim, Hyun Joo Cho, Yoon Jung Kim, Myung Jin Cho, Hae Yoon Choi, Chai Ryoung Eun, Joo Hyung Kim, Sae Jeong Yang, Hye-Jin Yoo, Hee Young Kim, Ji A Seo, Sin Gon Kim, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BackgroundIt is unclear whether prehypertension by the seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) criteria (systolic blood pressure (SBP) 120-139 or diastolic blood pressure (DBP) 80-89mmHg) or high-normal blood pressure (HNBP) by the European Society of Hypertension and European Society of Cardiology (ESH/ESC) criteria (SBP 130-139 or DBP 85-89mmHg) predicts mortality in elderly Koreans. We compared the mortality risk between those with prehypertension and HNBP and evaluated whether the presence of components of metabolic syndrome (MetS) can improve the prediction of mortality in subjects with HNBP.MethodsWe analyzed all-cause and cardiovascular disease (CVD) mortality according to the JNC-7 and ESH/ESC categories using follow-up data of the South-West Seoul (SWS) Study, a prospective cohort study of 2,376 elderly Koreans, aged 60 years.ResultsDuring the median follow-up of 7.6 years, 353 deaths occurred from all causes, and 113 of these were attributed to CVD. Prehypertension was nonsignificantly associated with an increased risk of mortality (hazard ratio (HR): 1.06, 95% confidence interval (CI): 0.68-1.64). Subjects with HNBP exhibited a nonsignificantly higher risk of mortality compared with those with optimal blood pressure by the ESH/ESC guideline (HR: 1.35, 95% CI: 0.84-2.18). However, the combination of low high-density lipoprotein (HDL) cholesterol and HNBP showed a twofold higher risk of all-cause mortality (HR: 2.01, 95% CI: 1.11-3.64) independent of other risk factors.ConclusionsAlthough prehypertension was not associated with increased risk of mortality, individuals in the elderly Korean population with HNBP, especially when combined with low HDL cholesterol, showed a significantly increased risk of all-cause mortality.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalAmerican Journal of Hypertension
Volume24
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

Fingerprint

LDL Cholesterol
HDL Cholesterol
Blood Pressure
Hypertension
Prehypertension
Mortality
Population
Confidence Intervals
Cardiology
Cardiovascular Diseases
Seoul
Cohort Studies
Prospective Studies
Guidelines

Keywords

  • blood pressure
  • elderly
  • high-normal blood pressure
  • hypertension
  • Koreans
  • metabolic syndrome
  • prehypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Combined effect of high-normal blood pressure and low HDL cholesterol on mortality in an elderly Korean Population : The South-West Seoul (SWS) Study. / Kim, Nan Hee; Cho, Hyun Joo; Kim, Yoon Jung; Cho, Myung Jin; Choi, Hae Yoon; Eun, Chai Ryoung; Kim, Joo Hyung; Yang, Sae Jeong; Yoo, Hye-Jin; Kim, Hee Young; Seo, Ji A; Kim, Sin Gon; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: American Journal of Hypertension, Vol. 24, No. 8, 01.08.2011, p. 918-923.

Research output: Contribution to journalArticle

Kim, Nan Hee ; Cho, Hyun Joo ; Kim, Yoon Jung ; Cho, Myung Jin ; Choi, Hae Yoon ; Eun, Chai Ryoung ; Kim, Joo Hyung ; Yang, Sae Jeong ; Yoo, Hye-Jin ; Kim, Hee Young ; Seo, Ji A ; Kim, Sin Gon ; Baik, Sei-Hyun ; Choi, Dong Seop ; Choi, Kyung Mook. / Combined effect of high-normal blood pressure and low HDL cholesterol on mortality in an elderly Korean Population : The South-West Seoul (SWS) Study. In: American Journal of Hypertension. 2011 ; Vol. 24, No. 8. pp. 918-923.
@article{c48a08e6a4014426b0798f926ef88f2b,
title = "Combined effect of high-normal blood pressure and low HDL cholesterol on mortality in an elderly Korean Population: The South-West Seoul (SWS) Study",
abstract = "BackgroundIt is unclear whether prehypertension by the seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) criteria (systolic blood pressure (SBP) 120-139 or diastolic blood pressure (DBP) 80-89mmHg) or high-normal blood pressure (HNBP) by the European Society of Hypertension and European Society of Cardiology (ESH/ESC) criteria (SBP 130-139 or DBP 85-89mmHg) predicts mortality in elderly Koreans. We compared the mortality risk between those with prehypertension and HNBP and evaluated whether the presence of components of metabolic syndrome (MetS) can improve the prediction of mortality in subjects with HNBP.MethodsWe analyzed all-cause and cardiovascular disease (CVD) mortality according to the JNC-7 and ESH/ESC categories using follow-up data of the South-West Seoul (SWS) Study, a prospective cohort study of 2,376 elderly Koreans, aged 60 years.ResultsDuring the median follow-up of 7.6 years, 353 deaths occurred from all causes, and 113 of these were attributed to CVD. Prehypertension was nonsignificantly associated with an increased risk of mortality (hazard ratio (HR): 1.06, 95{\%} confidence interval (CI): 0.68-1.64). Subjects with HNBP exhibited a nonsignificantly higher risk of mortality compared with those with optimal blood pressure by the ESH/ESC guideline (HR: 1.35, 95{\%} CI: 0.84-2.18). However, the combination of low high-density lipoprotein (HDL) cholesterol and HNBP showed a twofold higher risk of all-cause mortality (HR: 2.01, 95{\%} CI: 1.11-3.64) independent of other risk factors.ConclusionsAlthough prehypertension was not associated with increased risk of mortality, individuals in the elderly Korean population with HNBP, especially when combined with low HDL cholesterol, showed a significantly increased risk of all-cause mortality.",
keywords = "blood pressure, elderly, high-normal blood pressure, hypertension, Koreans, metabolic syndrome, prehypertension",
author = "Kim, {Nan Hee} and Cho, {Hyun Joo} and Kim, {Yoon Jung} and Cho, {Myung Jin} and Choi, {Hae Yoon} and Eun, {Chai Ryoung} and Kim, {Joo Hyung} and Yang, {Sae Jeong} and Hye-Jin Yoo and Kim, {Hee Young} and Seo, {Ji A} and Kim, {Sin Gon} and Sei-Hyun Baik and Choi, {Dong Seop} and Choi, {Kyung Mook}",
year = "2011",
month = "8",
day = "1",
doi = "10.1038/ajh.2011.78",
language = "English",
volume = "24",
pages = "918--923",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Combined effect of high-normal blood pressure and low HDL cholesterol on mortality in an elderly Korean Population

T2 - The South-West Seoul (SWS) Study

AU - Kim, Nan Hee

AU - Cho, Hyun Joo

AU - Kim, Yoon Jung

AU - Cho, Myung Jin

AU - Choi, Hae Yoon

AU - Eun, Chai Ryoung

AU - Kim, Joo Hyung

AU - Yang, Sae Jeong

AU - Yoo, Hye-Jin

AU - Kim, Hee Young

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

PY - 2011/8/1

Y1 - 2011/8/1

N2 - BackgroundIt is unclear whether prehypertension by the seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) criteria (systolic blood pressure (SBP) 120-139 or diastolic blood pressure (DBP) 80-89mmHg) or high-normal blood pressure (HNBP) by the European Society of Hypertension and European Society of Cardiology (ESH/ESC) criteria (SBP 130-139 or DBP 85-89mmHg) predicts mortality in elderly Koreans. We compared the mortality risk between those with prehypertension and HNBP and evaluated whether the presence of components of metabolic syndrome (MetS) can improve the prediction of mortality in subjects with HNBP.MethodsWe analyzed all-cause and cardiovascular disease (CVD) mortality according to the JNC-7 and ESH/ESC categories using follow-up data of the South-West Seoul (SWS) Study, a prospective cohort study of 2,376 elderly Koreans, aged 60 years.ResultsDuring the median follow-up of 7.6 years, 353 deaths occurred from all causes, and 113 of these were attributed to CVD. Prehypertension was nonsignificantly associated with an increased risk of mortality (hazard ratio (HR): 1.06, 95% confidence interval (CI): 0.68-1.64). Subjects with HNBP exhibited a nonsignificantly higher risk of mortality compared with those with optimal blood pressure by the ESH/ESC guideline (HR: 1.35, 95% CI: 0.84-2.18). However, the combination of low high-density lipoprotein (HDL) cholesterol and HNBP showed a twofold higher risk of all-cause mortality (HR: 2.01, 95% CI: 1.11-3.64) independent of other risk factors.ConclusionsAlthough prehypertension was not associated with increased risk of mortality, individuals in the elderly Korean population with HNBP, especially when combined with low HDL cholesterol, showed a significantly increased risk of all-cause mortality.

AB - BackgroundIt is unclear whether prehypertension by the seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) criteria (systolic blood pressure (SBP) 120-139 or diastolic blood pressure (DBP) 80-89mmHg) or high-normal blood pressure (HNBP) by the European Society of Hypertension and European Society of Cardiology (ESH/ESC) criteria (SBP 130-139 or DBP 85-89mmHg) predicts mortality in elderly Koreans. We compared the mortality risk between those with prehypertension and HNBP and evaluated whether the presence of components of metabolic syndrome (MetS) can improve the prediction of mortality in subjects with HNBP.MethodsWe analyzed all-cause and cardiovascular disease (CVD) mortality according to the JNC-7 and ESH/ESC categories using follow-up data of the South-West Seoul (SWS) Study, a prospective cohort study of 2,376 elderly Koreans, aged 60 years.ResultsDuring the median follow-up of 7.6 years, 353 deaths occurred from all causes, and 113 of these were attributed to CVD. Prehypertension was nonsignificantly associated with an increased risk of mortality (hazard ratio (HR): 1.06, 95% confidence interval (CI): 0.68-1.64). Subjects with HNBP exhibited a nonsignificantly higher risk of mortality compared with those with optimal blood pressure by the ESH/ESC guideline (HR: 1.35, 95% CI: 0.84-2.18). However, the combination of low high-density lipoprotein (HDL) cholesterol and HNBP showed a twofold higher risk of all-cause mortality (HR: 2.01, 95% CI: 1.11-3.64) independent of other risk factors.ConclusionsAlthough prehypertension was not associated with increased risk of mortality, individuals in the elderly Korean population with HNBP, especially when combined with low HDL cholesterol, showed a significantly increased risk of all-cause mortality.

KW - blood pressure

KW - elderly

KW - high-normal blood pressure

KW - hypertension

KW - Koreans

KW - metabolic syndrome

KW - prehypertension

UR - http://www.scopus.com/inward/record.url?scp=79960557815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960557815&partnerID=8YFLogxK

U2 - 10.1038/ajh.2011.78

DO - 10.1038/ajh.2011.78

M3 - Article

VL - 24

SP - 918

EP - 923

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 8

ER -