Combined effects of water quality parameters on mixture toxicity of copper and chromium toward Daphnia magna

Hun Je Jo, Jino Son, Ki Jong Cho, Jinho Jung

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14 Citations (Scopus)


In this study, a central composite design (CCD) was employed to evaluate the combined effects of pH, hardness and dissolved organic carbon (DOC) on the toxicity of a mixture of Cu(II) and Cr(VI) toward Daphnia magna. Overall, the results showed that increases in pH, hardness and DOC concentration led to decreased mixture toxicity of Cu(II) and Cr(VI) by reducing the concentrations of toxic species such as Cu2+ and HCrO4-In addition, empirical models for the prediction of 24-h and 48-h mortalities of D. magna were developed and validated by using three different sources of dissolved organic matter (DOM). Because the DOMs had different Cu(II)-binding capacities, the empirical models were revised using the ligand concentration of DOMs instead of the DOC concentration; however, the prediction capability of these models did not differ significantly. These results suggest that it is not likely that the chemical property of DOM is important for prediction of the mixture toxicity of Cu(II) and Cr(VI) toward D. magna when the ligand concentration of DOMs greatly exceed the Cu(II) concentration.

Original languageEnglish
Pages (from-to)1301-1307
Number of pages7
Issue number10
Publication statusPublished - 2010 Nov 1



  • Central composite design
  • Chromium
  • Copper
  • Daphnia magna
  • Empirical model
  • Mixture toxicity

ASJC Scopus subject areas

  • Environmental Chemistry
  • Chemistry(all)

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