Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

Le Yu, Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim

Research output: Contribution to journalArticle

Abstract

We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.

Original languageEnglish
Pages (from-to)6684-6687
Number of pages4
JournalChemical Communications
Volume56
Issue number49
DOIs
Publication statusPublished - 2020 Jun 21

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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