Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

Le Yu; Le Yu; Jun Feng Zhang; Mingle Li; Dewei Jiang; Ying Zhou; Peter Verwilst; Jong Seung Kim

doi:10.1039/d0cc02943b

Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

Le Yu, Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.

Original language	English
Pages (from-to)	6684-6687
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	49
DOIs	https://doi.org/10.1039/d0cc02943b
Publication status	Published - 2020 Jun 21

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization",

abstract = "We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.",

author = "Le Yu and Le Yu and Zhang, {Jun Feng} and Mingle Li and Dewei Jiang and Ying Zhou and Peter Verwilst and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by CRI project no. 2018R1A3B1052702 (J.S.K.) of the National Research Foundation (NRF) grant funded by the Korean government. Zhou and Zhang acknowledge the support from the National Natural Science Foundation of China (No. 21672185 and 21867019). Jiang is grateful to the project of innovative research team of Yunnan province (2019HC005) and Yunnan fundamental research project 2019FB112.",

year = "2020",

month = jun,

day = "21",

doi = "10.1039/d0cc02943b",

language = "English",

volume = "56",

pages = "6684--6687",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "49",

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TY - JOUR

T1 - Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

AU - Yu, Le

AU - Zhang, Jun Feng

AU - Li, Mingle

AU - Jiang, Dewei

AU - Zhou, Ying

AU - Verwilst, Peter

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by CRI project no. 2018R1A3B1052702 (J.S.K.) of the National Research Foundation (NRF) grant funded by the Korean government. Zhou and Zhang acknowledge the support from the National Natural Science Foundation of China (No. 21672185 and 21867019). Jiang is grateful to the project of innovative research team of Yunnan province (2019HC005) and Yunnan fundamental research project 2019FB112.

PY - 2020/6/21

Y1 - 2020/6/21

N2 - We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.

AB - We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.

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