CoMIC, the hidden dynamics of mitochondrial inner compartments

Bongki Cho, Woong Sun

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division.

Original languageEnglish
Pages (from-to)597-598
Number of pages2
JournalBMB Reports
Volume50
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • Calcium
  • Constriction
  • Division
  • Drp1
  • Mitochondria

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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