Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis

T. Wise, J. Radua, E. Via, N. Cardoner, O. Abe, T. M. Adams, F. Amico, Y. Cheng, J. H. Cole, C. de Azevedo Marques Périco, D. P. Dickstein, T. F D Farrow, T. Frodl, G. Wagner, I. H. Gotlib, O. Gruber, Byung-Joo Ham, D. E. Job, M. J. Kempton, M. J. KimP. C M P Koolschijn, G. S. Malhi, D. Mataix-Cols, A. M. McIntosh, A. C. Nugent, J. T. O'Brien, S. Pezzoli, M. L. Phillips, P. S. Sachdev, G. Salvadore, S. Selvaraj, A. C. Stanfield, A. J. Thomas, M. J. van Tol, N. J A van der Wee, D. J. Veltman, A. H. Young, C. H. Fu, A. J. Cleare, D. Arnone

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.72.

Original languageEnglish
JournalMolecular Psychiatry
DOIs
Publication statusAccepted/In press - 2016 May 24

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Bipolar Disorder
Meta-Analysis
Depression
Prefrontal Cortex
Parietal Lobe
Gyrus Cinguli
Brain
Temporal Lobe
Mood Disorders
Psychiatry
Publications
Hippocampus
Biomarkers
Gray Matter
Research
Datasets

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder : evidence from voxel-based meta-analysis. / Wise, T.; Radua, J.; Via, E.; Cardoner, N.; Abe, O.; Adams, T. M.; Amico, F.; Cheng, Y.; Cole, J. H.; de Azevedo Marques Périco, C.; Dickstein, D. P.; Farrow, T. F D; Frodl, T.; Wagner, G.; Gotlib, I. H.; Gruber, O.; Ham, Byung-Joo; Job, D. E.; Kempton, M. J.; Kim, M. J.; Koolschijn, P. C M P; Malhi, G. S.; Mataix-Cols, D.; McIntosh, A. M.; Nugent, A. C.; O'Brien, J. T.; Pezzoli, S.; Phillips, M. L.; Sachdev, P. S.; Salvadore, G.; Selvaraj, S.; Stanfield, A. C.; Thomas, A. J.; van Tol, M. J.; van der Wee, N. J A; Veltman, D. J.; Young, A. H.; Fu, C. H.; Cleare, A. J.; Arnone, D.

In: Molecular Psychiatry, 24.05.2016.

Research output: Contribution to journalArticle

Wise, T, Radua, J, Via, E, Cardoner, N, Abe, O, Adams, TM, Amico, F, Cheng, Y, Cole, JH, de Azevedo Marques Périco, C, Dickstein, DP, Farrow, TFD, Frodl, T, Wagner, G, Gotlib, IH, Gruber, O, Ham, B-J, Job, DE, Kempton, MJ, Kim, MJ, Koolschijn, PCMP, Malhi, GS, Mataix-Cols, D, McIntosh, AM, Nugent, AC, O'Brien, JT, Pezzoli, S, Phillips, ML, Sachdev, PS, Salvadore, G, Selvaraj, S, Stanfield, AC, Thomas, AJ, van Tol, MJ, van der Wee, NJA, Veltman, DJ, Young, AH, Fu, CH, Cleare, AJ & Arnone, D 2016, 'Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis', Molecular Psychiatry. https://doi.org/10.1038/mp.2016.72
Wise, T. ; Radua, J. ; Via, E. ; Cardoner, N. ; Abe, O. ; Adams, T. M. ; Amico, F. ; Cheng, Y. ; Cole, J. H. ; de Azevedo Marques Périco, C. ; Dickstein, D. P. ; Farrow, T. F D ; Frodl, T. ; Wagner, G. ; Gotlib, I. H. ; Gruber, O. ; Ham, Byung-Joo ; Job, D. E. ; Kempton, M. J. ; Kim, M. J. ; Koolschijn, P. C M P ; Malhi, G. S. ; Mataix-Cols, D. ; McIntosh, A. M. ; Nugent, A. C. ; O'Brien, J. T. ; Pezzoli, S. ; Phillips, M. L. ; Sachdev, P. S. ; Salvadore, G. ; Selvaraj, S. ; Stanfield, A. C. ; Thomas, A. J. ; van Tol, M. J. ; van der Wee, N. J A ; Veltman, D. J. ; Young, A. H. ; Fu, C. H. ; Cleare, A. J. ; Arnone, D. / Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder : evidence from voxel-based meta-analysis. In: Molecular Psychiatry. 2016.
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title = "Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis",
abstract = "Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.72.",
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T1 - Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder

T2 - evidence from voxel-based meta-analysis

AU - Wise, T.

AU - Radua, J.

AU - Via, E.

AU - Cardoner, N.

AU - Abe, O.

AU - Adams, T. M.

AU - Amico, F.

AU - Cheng, Y.

AU - Cole, J. H.

AU - de Azevedo Marques Périco, C.

AU - Dickstein, D. P.

AU - Farrow, T. F D

AU - Frodl, T.

AU - Wagner, G.

AU - Gotlib, I. H.

AU - Gruber, O.

AU - Ham, Byung-Joo

AU - Job, D. E.

AU - Kempton, M. J.

AU - Kim, M. J.

AU - Koolschijn, P. C M P

AU - Malhi, G. S.

AU - Mataix-Cols, D.

AU - McIntosh, A. M.

AU - Nugent, A. C.

AU - O'Brien, J. T.

AU - Pezzoli, S.

AU - Phillips, M. L.

AU - Sachdev, P. S.

AU - Salvadore, G.

AU - Selvaraj, S.

AU - Stanfield, A. C.

AU - Thomas, A. J.

AU - van Tol, M. J.

AU - van der Wee, N. J A

AU - Veltman, D. J.

AU - Young, A. H.

AU - Fu, C. H.

AU - Cleare, A. J.

AU - Arnone, D.

PY - 2016/5/24

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N2 - Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.72.

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