Compact CdZnTe-based gamma camera for prostate cancer imaging

Yonggang Cui, Terry Lall, Benjamin Tsui, Jianhua Yu, George Mahler, Aleksey Bolotnikov, Paul Vaska, Gianluigi De Geronimo, Paul O'Connor, George Meinken, John Joyal, John Barrettf, Giuseppe Camarda, Anwar Hossain, Kihyun Kim, Ge Yang, Marty Pomper, Steve Cho, Ken Weisman, Youngho SeoJohn Babich, Norman LaFrance, Ralph B. James

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high falsepositive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integratedcircuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera have been completed. The results show better than 6-mm resolution at a distance of 1 cm. Details of the test results are discussed in this paper.

Original languageEnglish
Title of host publicationInternational Symposium on Photoelectronic Detection and Imaging 2011
Subtitle of host publicationLaser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging
DOIs
Publication statusPublished - 2011 Sep 12
Externally publishedYes
EventInternational Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging - Beijing, China
Duration: 2011 May 242011 May 26

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8192
ISSN (Print)0277-786X

Conference

ConferenceInternational Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging
CountryChina
CityBeijing
Period11/5/2411/5/26

Fingerprint

Cadmium compounds
Cadmium alloys
cadmium alloys
Ultrasonic applications
cadmium compounds
Z transforms
CdZnTe
Single photon emission computed tomography
Radiation Detectors
Cadmium telluride
Histology
Radiation detectors
Radiotherapy
Prostate Cancer
cadmium tellurides
histology
Medical Applications
Biopsy
Semiconductor Lasers
Electron mobility

Keywords

  • CdZnTe
  • Gamma Camera
  • Nuclear Medical Imaging
  • Prostate Cancer
  • Radiation Detectors

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Cui, Y., Lall, T., Tsui, B., Yu, J., Mahler, G., Bolotnikov, A., ... James, R. B. (2011). Compact CdZnTe-based gamma camera for prostate cancer imaging. In International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging [819255] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8192). https://doi.org/10.1117/12.901078

Compact CdZnTe-based gamma camera for prostate cancer imaging. / Cui, Yonggang; Lall, Terry; Tsui, Benjamin; Yu, Jianhua; Mahler, George; Bolotnikov, Aleksey; Vaska, Paul; De Geronimo, Gianluigi; O'Connor, Paul; Meinken, George; Joyal, John; Barrettf, John; Camarda, Giuseppe; Hossain, Anwar; Kim, Kihyun; Yang, Ge; Pomper, Marty; Cho, Steve; Weisman, Ken; Seo, Youngho; Babich, John; LaFrance, Norman; James, Ralph B.

International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging. 2011. 819255 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cui, Y, Lall, T, Tsui, B, Yu, J, Mahler, G, Bolotnikov, A, Vaska, P, De Geronimo, G, O'Connor, P, Meinken, G, Joyal, J, Barrettf, J, Camarda, G, Hossain, A, Kim, K, Yang, G, Pomper, M, Cho, S, Weisman, K, Seo, Y, Babich, J, LaFrance, N & James, RB 2011, Compact CdZnTe-based gamma camera for prostate cancer imaging. in International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging., 819255, Proceedings of SPIE - The International Society for Optical Engineering, vol. 8192, International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging, Beijing, China, 11/5/24. https://doi.org/10.1117/12.901078
Cui Y, Lall T, Tsui B, Yu J, Mahler G, Bolotnikov A et al. Compact CdZnTe-based gamma camera for prostate cancer imaging. In International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging. 2011. 819255. (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.901078
Cui, Yonggang ; Lall, Terry ; Tsui, Benjamin ; Yu, Jianhua ; Mahler, George ; Bolotnikov, Aleksey ; Vaska, Paul ; De Geronimo, Gianluigi ; O'Connor, Paul ; Meinken, George ; Joyal, John ; Barrettf, John ; Camarda, Giuseppe ; Hossain, Anwar ; Kim, Kihyun ; Yang, Ge ; Pomper, Marty ; Cho, Steve ; Weisman, Ken ; Seo, Youngho ; Babich, John ; LaFrance, Norman ; James, Ralph B. / Compact CdZnTe-based gamma camera for prostate cancer imaging. International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging. 2011. (Proceedings of SPIE - The International Society for Optical Engineering).
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AU - Pomper, Marty

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