Comparative effects of various absorbable threads in a rat model

Jung Jin Shin, Tae Jun Park, Bo Young Kim, Chang Min Kim, Dong Hye Suh, Sang Jun Lee, Hye Rim Moon, Hwa Jung Ryu

Research output: Contribution to journalArticle

Abstract

Background: Conventional procedures including botulinum toxin and filler injections have their limitations in improving deep wrinkles and decreasing tissue laxity, and possess the propensity for vascular accidents. Absorbable thread is a recently commercialized field, but there is little evidence on comparative superiority. Objectives: We observed the effects of polydiaxanone (PDO) threads with different number of strands in relation to collagen production and histopathology in a rat model. Materials and methods: Dorsal skin of rat was divided into five different compartments and four different PDO threads and monofilament poly-lactic acid (PLA) thread were inserted. Tissue samples were obtained at week 1, 2, and 12 after the procedure for histopathologic review and real-time PCR for quantification of collagen. Results: Multiple PDO filaments produced more collagen at 2 weeks. Single-stranded PLA thread insertion resulted in more Col1α1 levels than the double PDO thread and also showed the most Col1α3 production at week 2. The amount of collagen showed a sharp decline at week 12. Histologic evaluation showed retained threads surrounded by fibrous capsule-like structure at week 12. Conclusion: We were able to observe more collagen production in multiple stranded PDO threads compared to a single strand and that increasing number of threads leads to more collagen synthesis.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Cosmetic and Laser Therapy
DOIs
Publication statusAccepted/In press - 2018 Jul 7

Fingerprint

Collagen
Botulinum Toxins
Capsules
Accidents
Blood Vessels
Real-Time Polymerase Chain Reaction
Skin
Injections
poly(lactic acid)

Keywords

  • Absorbable threads
  • collagen changes
  • polydiaxanone
  • skin rejuvenation

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Comparative effects of various absorbable threads in a rat model. / Shin, Jung Jin; Park, Tae Jun; Kim, Bo Young; Kim, Chang Min; Suh, Dong Hye; Lee, Sang Jun; Moon, Hye Rim; Ryu, Hwa Jung.

In: Journal of Cosmetic and Laser Therapy, 07.07.2018, p. 1-5.

Research output: Contribution to journalArticle

Shin, Jung Jin ; Park, Tae Jun ; Kim, Bo Young ; Kim, Chang Min ; Suh, Dong Hye ; Lee, Sang Jun ; Moon, Hye Rim ; Ryu, Hwa Jung. / Comparative effects of various absorbable threads in a rat model. In: Journal of Cosmetic and Laser Therapy. 2018 ; pp. 1-5.
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