Comparative study of dual-pulsed 1064 nm Q-switched Nd

YAG laser and single-pulsed 1064 nm Q-switched Nd:YAG laser by using zebrafish model and prospective split-face analysis of facial melasma

Hee Won Jang, Seung Hyun Chun, Hae Chul Park, Hwa Jung Ryu, Il-Hwan Kim

Research output: Contribution to journalArticle

Abstract

Background: Recently dual-pulsed low-fluence 1064-nm Q-switched Nd:YAG (QSNY) laser has been developed for reducing complication during melasma treatment. Objective: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. Materials and methods: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed. In split-face clinical study, dual-pulsed and single-pulsed mode were irradiated on the left and right side of the face, respectively. L* value, clinical digital photos, modified Melasma Area and Severity Index (MASI) scores, and side effects were measured. Results: As compared to single-pulsed mode and dual-pulsed mode with longer intervals, zebrafish melanophore was cleared quickly at dual-pulsed mode with 80-μsec interval and 0.3 J/cm2 fluence. Dual-pulsed mode showed the least regeneration of melanophore at 4 weeks after irradiation and no cell death was observed with 80-μsec interval. Both pulse modes improved melasma significantly but modified MASI score and L* value were not significantly different between each other. Lesser pain and shorter duration of post-laser erythema were observed with dual-pulsed mode. Conclusion: Dual-pulsed mode was as effective as single-pulsed mode for the treatment of melasma and revealed less side effects.

Original languageEnglish
Pages (from-to)114-123
Number of pages10
JournalJournal of Cosmetic and Laser Therapy
Volume19
Issue number2
DOIs
Publication statusPublished - 2017 Feb 17

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Melanosis
Solid-State Lasers
Zebrafish
Melanophores
Cell Death
Erythema
Regeneration
Lasers
Therapeutics
Safety
Pain

Keywords

  • melasma
  • Nd:YAG
  • zebrafish

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

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title = "Comparative study of dual-pulsed 1064 nm Q-switched Nd: YAG laser and single-pulsed 1064 nm Q-switched Nd:YAG laser by using zebrafish model and prospective split-face analysis of facial melasma",
abstract = "Background: Recently dual-pulsed low-fluence 1064-nm Q-switched Nd:YAG (QSNY) laser has been developed for reducing complication during melasma treatment. Objective: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. Materials and methods: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed. In split-face clinical study, dual-pulsed and single-pulsed mode were irradiated on the left and right side of the face, respectively. L* value, clinical digital photos, modified Melasma Area and Severity Index (MASI) scores, and side effects were measured. Results: As compared to single-pulsed mode and dual-pulsed mode with longer intervals, zebrafish melanophore was cleared quickly at dual-pulsed mode with 80-μsec interval and 0.3 J/cm2 fluence. Dual-pulsed mode showed the least regeneration of melanophore at 4 weeks after irradiation and no cell death was observed with 80-μsec interval. Both pulse modes improved melasma significantly but modified MASI score and L* value were not significantly different between each other. Lesser pain and shorter duration of post-laser erythema were observed with dual-pulsed mode. Conclusion: Dual-pulsed mode was as effective as single-pulsed mode for the treatment of melasma and revealed less side effects.",
keywords = "melasma, Nd:YAG, zebrafish",
author = "Jang, {Hee Won} and Chun, {Seung Hyun} and Park, {Hae Chul} and Ryu, {Hwa Jung} and Il-Hwan Kim",
year = "2017",
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T2 - YAG laser and single-pulsed 1064 nm Q-switched Nd:YAG laser by using zebrafish model and prospective split-face analysis of facial melasma

AU - Jang, Hee Won

AU - Chun, Seung Hyun

AU - Park, Hae Chul

AU - Ryu, Hwa Jung

AU - Kim, Il-Hwan

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N2 - Background: Recently dual-pulsed low-fluence 1064-nm Q-switched Nd:YAG (QSNY) laser has been developed for reducing complication during melasma treatment. Objective: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. Materials and methods: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed. In split-face clinical study, dual-pulsed and single-pulsed mode were irradiated on the left and right side of the face, respectively. L* value, clinical digital photos, modified Melasma Area and Severity Index (MASI) scores, and side effects were measured. Results: As compared to single-pulsed mode and dual-pulsed mode with longer intervals, zebrafish melanophore was cleared quickly at dual-pulsed mode with 80-μsec interval and 0.3 J/cm2 fluence. Dual-pulsed mode showed the least regeneration of melanophore at 4 weeks after irradiation and no cell death was observed with 80-μsec interval. Both pulse modes improved melasma significantly but modified MASI score and L* value were not significantly different between each other. Lesser pain and shorter duration of post-laser erythema were observed with dual-pulsed mode. Conclusion: Dual-pulsed mode was as effective as single-pulsed mode for the treatment of melasma and revealed less side effects.

AB - Background: Recently dual-pulsed low-fluence 1064-nm Q-switched Nd:YAG (QSNY) laser has been developed for reducing complication during melasma treatment. Objective: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. Materials and methods: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed. In split-face clinical study, dual-pulsed and single-pulsed mode were irradiated on the left and right side of the face, respectively. L* value, clinical digital photos, modified Melasma Area and Severity Index (MASI) scores, and side effects were measured. Results: As compared to single-pulsed mode and dual-pulsed mode with longer intervals, zebrafish melanophore was cleared quickly at dual-pulsed mode with 80-μsec interval and 0.3 J/cm2 fluence. Dual-pulsed mode showed the least regeneration of melanophore at 4 weeks after irradiation and no cell death was observed with 80-μsec interval. Both pulse modes improved melasma significantly but modified MASI score and L* value were not significantly different between each other. Lesser pain and shorter duration of post-laser erythema were observed with dual-pulsed mode. Conclusion: Dual-pulsed mode was as effective as single-pulsed mode for the treatment of melasma and revealed less side effects.

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