Comparative study of helicobacter pylori eradication rates with 5-day quadruple concomitant therapy and 7-day standard triple therapy

Seung Young Kim, Sang Woo Lee, Jong Jin Hyun, Sung Woo Jung, Ja Seol Koo, Hyung Joon Yim, Jong Jae Park, Hoon Jai Chun, Jai Hyun Choi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Several studies have shown the superiority of concomitant quadruple therapy containing 3 antibiotics over triple therapy for Helicobacter pylori infection. The aim of this study was to compare concomitant quadruple therapy with standard triple therapy for first-line H. pylori eradication. Background: A total of 270 patients with proven H. pylori infection were randomly assigned to one of 2 regimens: amoxicillin 1000 mg with clarithromycin 500 mg and lansoprazole 30 mg twice daily for 7 days (triple therapy) or amoxicillin 1000 mg with clarithromycin 500 mg, metronidazole 500 mg, and lansoprazole 30 mg twice daily for 5 days (concomitant therapy). The success of eradication was evaluated 4 to 5 weeks after completion of treatment. Results: Eradication rates were 86.1% in the triple therapy and 91.4% in the concomitant therapy (per protocol), but the difference was not statistically significant. Mild adverse events were more frequently reported in the concomitant-therapy group (35.6%) than in the triple-therapy group (25.2%) (P=0.09). Conclusions: Five-day quadruple concomitant therapy eradicated H. pylori in over 90% of patients. Accordingly, concomitant therapy is thought to be a promising alternative to triple therapy as a first-line treatment regimen for H. pylori eradication.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalJournal of Clinical Gastroenterology
Volume47
Issue number1
DOIs
Publication statusPublished - 2013 Jan

Keywords

  • Helicobacter pylori
  • combination
  • concomitant therapy
  • drug therapy

ASJC Scopus subject areas

  • Gastroenterology

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