Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients: Open-label, randomized, multicentre clinical trial

P. B. Lee, Y. C. Kim, Y. J. Lim, C. J. Lee, W. S. Sim, C. W. Ha, S. I. Bin, K. B. Lim, Sang Sik Choi, S. C. Lee

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Efficacy and safety of high and low molecular weight hyaluronates in knee osteoarthritis patients were compared in a randomized, open-label trial. Patients in the high molecular weight hyaluronate group were treated once weekly for 3 weeks and in the low molecular weight group once weekly for 5 weeks. We evaluated weight-bearing pain, degree of flexion, swelling and knee tenderness; frequency and amount of rescue medication; patient and investigator global assessment of pain, and safety over 12 weeks after final injection of study medication. Significant improvements in pain and WOMAC-Likert scores were observed in both groups, but not between groups. Knee joint pain improvement was noted in both groups by patients and investigators during follow-up. Close correlation was observed between patient-and investigator-reported data. There was no significant difference in side-effects between the groups. In conclusion, the efficacy and safety of high and low molecular weight hyaluronate are similar.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalJournal of International Medical Research
Issue number1
Publication statusPublished - 2006 Jan 1



  • Adults
  • High molecular weight
  • Hyaluronate
  • Knees
  • Low molecular weight
  • Osteoarthritis
  • WOMAC-likert scores

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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