Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients

Open-label, randomized, multicentre clinical trial

P. B. Lee, Y. C. Kim, Y. J. Lim, C. J. Lee, W. S. Sim, C. W. Ha, S. I. Bin, K. B. Lim, Sang Sik Choi, S. C. Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Efficacy and safety of high and low molecular weight hyaluronates in knee osteoarthritis patients were compared in a randomized, open-label trial. Patients in the high molecular weight hyaluronate group were treated once weekly for 3 weeks and in the low molecular weight group once weekly for 5 weeks. We evaluated weight-bearing pain, degree of flexion, swelling and knee tenderness; frequency and amount of rescue medication; patient and investigator global assessment of pain, and safety over 12 weeks after final injection of study medication. Significant improvements in pain and WOMAC-Likert scores were observed in both groups, but not between groups. Knee joint pain improvement was noted in both groups by patients and investigators during follow-up. Close correlation was observed between patient-and investigator-reported data. There was no significant difference in side-effects between the groups. In conclusion, the efficacy and safety of high and low molecular weight hyaluronate are similar.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalJournal of International Medical Research
Volume34
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

Fingerprint

Knee Osteoarthritis
Multicenter Studies
Labels
Randomized Controlled Trials
Molecular Weight
Molecular weight
Research Personnel
Bearings (structural)
Safety
Pain
Swelling
Weight-Bearing
Arthralgia
Pain Measurement
Knee Joint
Knee
Injections

Keywords

  • Adults
  • High molecular weight
  • Hyaluronate
  • Knees
  • Low molecular weight
  • Osteoarthritis
  • WOMAC-likert scores

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients : Open-label, randomized, multicentre clinical trial. / Lee, P. B.; Kim, Y. C.; Lim, Y. J.; Lee, C. J.; Sim, W. S.; Ha, C. W.; Bin, S. I.; Lim, K. B.; Choi, Sang Sik; Lee, S. C.

In: Journal of International Medical Research, Vol. 34, No. 1, 01.01.2006, p. 77-87.

Research output: Contribution to journalArticle

Lee, P. B. ; Kim, Y. C. ; Lim, Y. J. ; Lee, C. J. ; Sim, W. S. ; Ha, C. W. ; Bin, S. I. ; Lim, K. B. ; Choi, Sang Sik ; Lee, S. C. / Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients : Open-label, randomized, multicentre clinical trial. In: Journal of International Medical Research. 2006 ; Vol. 34, No. 1. pp. 77-87.
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