Comparison of ΔFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma

Hee Choi Sun, Kyun Kim Do, Young Yoo, Jinho Yu, Yull Koh Young

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: In asthmatic individuals, airway sensitivity and maximal airway response are increased. Airway sensitivity is usually evaluated by measuring the provocation concentration of inhaled methacholine or histamine that causes a decrease in forced expiratory volume in 1 second of 20% (PC20). The percentage decrease in forced vital capacity at the PC20 (ΔFVC) has been proposed as a surrogate marker for maximal airway response. Individuals with allergic rhinitis and no clinical evidence of asthma frequently exhibit airway hypersensitivity. Objective: To compare the ΔFVC between patients with allergic rhinitis and mild asthmatic patients with a similar degree of airway hypersensitivity. Methods: A retrospective analysis of methacholine challenge test data from 72 children with allergic rhinitis and airway hypersensitivity (methacholine PC20 <16 mg/mL) (rhinitis group) and from 72 children with mild atopic asthma matched to the rhinitis group regarding the methacholine PC20 (asthma group). The ΔFVC was calculated on the concentration-response curve to methacholine. Results: The mean ± SD ΔFVC was significantly lower in the rhinitis group (15.0% ± 3.6%) vs the asthma group (17.4% ± 5.3%) (P = .002). There was no significant correlation between the ΔFVC and PC20 in the rhinitis (r = -0.101; P = .41) and asthma (r = -0.023; P = .85) groups when 2 patients with PC20 less than 1 mg/mL were excluded from each group. Conclusions: Patients with allergic rhinitis and airway hypersensitivity had a significantly lower ΔFVC than methacholine PC20-matched mild asthmatic patients, suggesting that the level of maximal airway response in patients with allergic rhinitis is lower than that in mild asthmatic patients with a similar degree of airway hypersensitivity.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalAnnals of Allergy, Asthma and Immunology
Volume98
Issue number2
Publication statusPublished - 2007 Jan 1

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Methacholine Chloride
Hypersensitivity
Asthma
Rhinitis
Vital Capacity
Forced Expiratory Volume
Allergic Rhinitis
Histamine
Biomarkers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Comparison of ΔFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma. / Sun, Hee Choi; Do, Kyun Kim; Yoo, Young; Yu, Jinho; Young, Yull Koh.

In: Annals of Allergy, Asthma and Immunology, Vol. 98, No. 2, 01.01.2007, p. 128-133.

Research output: Contribution to journalArticle

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abstract = "Background: In asthmatic individuals, airway sensitivity and maximal airway response are increased. Airway sensitivity is usually evaluated by measuring the provocation concentration of inhaled methacholine or histamine that causes a decrease in forced expiratory volume in 1 second of 20{\%} (PC20). The percentage decrease in forced vital capacity at the PC20 (ΔFVC) has been proposed as a surrogate marker for maximal airway response. Individuals with allergic rhinitis and no clinical evidence of asthma frequently exhibit airway hypersensitivity. Objective: To compare the ΔFVC between patients with allergic rhinitis and mild asthmatic patients with a similar degree of airway hypersensitivity. Methods: A retrospective analysis of methacholine challenge test data from 72 children with allergic rhinitis and airway hypersensitivity (methacholine PC20 <16 mg/mL) (rhinitis group) and from 72 children with mild atopic asthma matched to the rhinitis group regarding the methacholine PC20 (asthma group). The ΔFVC was calculated on the concentration-response curve to methacholine. Results: The mean ± SD ΔFVC was significantly lower in the rhinitis group (15.0{\%} ± 3.6{\%}) vs the asthma group (17.4{\%} ± 5.3{\%}) (P = .002). There was no significant correlation between the ΔFVC and PC20 in the rhinitis (r = -0.101; P = .41) and asthma (r = -0.023; P = .85) groups when 2 patients with PC20 less than 1 mg/mL were excluded from each group. Conclusions: Patients with allergic rhinitis and airway hypersensitivity had a significantly lower ΔFVC than methacholine PC20-matched mild asthmatic patients, suggesting that the level of maximal airway response in patients with allergic rhinitis is lower than that in mild asthmatic patients with a similar degree of airway hypersensitivity.",
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N2 - Background: In asthmatic individuals, airway sensitivity and maximal airway response are increased. Airway sensitivity is usually evaluated by measuring the provocation concentration of inhaled methacholine or histamine that causes a decrease in forced expiratory volume in 1 second of 20% (PC20). The percentage decrease in forced vital capacity at the PC20 (ΔFVC) has been proposed as a surrogate marker for maximal airway response. Individuals with allergic rhinitis and no clinical evidence of asthma frequently exhibit airway hypersensitivity. Objective: To compare the ΔFVC between patients with allergic rhinitis and mild asthmatic patients with a similar degree of airway hypersensitivity. Methods: A retrospective analysis of methacholine challenge test data from 72 children with allergic rhinitis and airway hypersensitivity (methacholine PC20 <16 mg/mL) (rhinitis group) and from 72 children with mild atopic asthma matched to the rhinitis group regarding the methacholine PC20 (asthma group). The ΔFVC was calculated on the concentration-response curve to methacholine. Results: The mean ± SD ΔFVC was significantly lower in the rhinitis group (15.0% ± 3.6%) vs the asthma group (17.4% ± 5.3%) (P = .002). There was no significant correlation between the ΔFVC and PC20 in the rhinitis (r = -0.101; P = .41) and asthma (r = -0.023; P = .85) groups when 2 patients with PC20 less than 1 mg/mL were excluded from each group. Conclusions: Patients with allergic rhinitis and airway hypersensitivity had a significantly lower ΔFVC than methacholine PC20-matched mild asthmatic patients, suggesting that the level of maximal airway response in patients with allergic rhinitis is lower than that in mild asthmatic patients with a similar degree of airway hypersensitivity.

AB - Background: In asthmatic individuals, airway sensitivity and maximal airway response are increased. Airway sensitivity is usually evaluated by measuring the provocation concentration of inhaled methacholine or histamine that causes a decrease in forced expiratory volume in 1 second of 20% (PC20). The percentage decrease in forced vital capacity at the PC20 (ΔFVC) has been proposed as a surrogate marker for maximal airway response. Individuals with allergic rhinitis and no clinical evidence of asthma frequently exhibit airway hypersensitivity. Objective: To compare the ΔFVC between patients with allergic rhinitis and mild asthmatic patients with a similar degree of airway hypersensitivity. Methods: A retrospective analysis of methacholine challenge test data from 72 children with allergic rhinitis and airway hypersensitivity (methacholine PC20 <16 mg/mL) (rhinitis group) and from 72 children with mild atopic asthma matched to the rhinitis group regarding the methacholine PC20 (asthma group). The ΔFVC was calculated on the concentration-response curve to methacholine. Results: The mean ± SD ΔFVC was significantly lower in the rhinitis group (15.0% ± 3.6%) vs the asthma group (17.4% ± 5.3%) (P = .002). There was no significant correlation between the ΔFVC and PC20 in the rhinitis (r = -0.101; P = .41) and asthma (r = -0.023; P = .85) groups when 2 patients with PC20 less than 1 mg/mL were excluded from each group. Conclusions: Patients with allergic rhinitis and airway hypersensitivity had a significantly lower ΔFVC than methacholine PC20-matched mild asthmatic patients, suggesting that the level of maximal airway response in patients with allergic rhinitis is lower than that in mild asthmatic patients with a similar degree of airway hypersensitivity.

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