Comparison of ΔFVC (% decrease in FVC at the PC20) between cough-variant asthma and classic asthma

Young Yoo, Jinho Yu, Sun Hee Lee, Do Kyun Kim, Sun Hee Choi, Chang Keun Kim, Young Yull Koh

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    11 Citations (Scopus)

    Abstract

    The percentage decrease in forced vital capacity (FVC) at the methacholine PC20 (Δ FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Δ FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (± SD) Δ FVC was significantly (p = 0.001) lower in the CVA group (14.7 ± 3.4%) compared with the CA group (17.1 ± 4.4%), whereas PC20 was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.

    Original languageEnglish
    Pages (from-to)35-38
    Number of pages4
    JournalJournal of Asthma
    Volume44
    Issue number1
    DOIs
    Publication statusPublished - 2007 Jan

    Keywords

    • Classic asthma
    • Cough-variant asthma
    • PC
    • ΔFVC

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Immunology and Allergy
    • Pulmonary and Respiratory Medicine

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