Comparison of ΔFVC (% decrease in FVC at the PC20) between cough-variant asthma and classic asthma

Young Yoo; Jinho Yu; Sun Hee Lee; Do Kyun Kim; Sun Hee Choi; Chang Keun Kim; Young Yull Koh

doi:10.1080/02770900601034379

Comparison of ΔFVC (% decrease in FVC at the PC20) between cough-variant asthma and classic asthma

Young Yoo, Jinho Yu, Sun Hee Lee, Do Kyun Kim, Sun Hee Choi, Chang Keun Kim, Young Yull Koh

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The percentage decrease in forced vital capacity (FVC) at the methacholine PC20 (Δ FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Δ FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (± SD) Δ FVC was significantly (p = 0.001) lower in the CVA group (14.7 ± 3.4%) compared with the CA group (17.1 ± 4.4%), whereas PC20 was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	Journal of Asthma
Volume	44
Issue number	1
DOIs	https://doi.org/10.1080/02770900601034379
Publication status	Published - 2007 Jan
Externally published	Yes

Keywords

Classic asthma
Cough-variant asthma
PC
ΔFVC

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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10.1080/02770900601034379

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title = "Comparison of ΔFVC (% decrease in FVC at the PC20) between cough-variant asthma and classic asthma",

abstract = "The percentage decrease in forced vital capacity (FVC) at the methacholine PC20 (Δ FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Δ FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (± SD) Δ FVC was significantly (p = 0.001) lower in the CVA group (14.7 ± 3.4%) compared with the CA group (17.1 ± 4.4%), whereas PC20 was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.",

keywords = "Classic asthma, Cough-variant asthma, PC, ΔFVC",

author = "Young Yoo and Jinho Yu and Lee, {Sun Hee} and Kim, {Do Kyun} and Choi, {Sun Hee} and Kim, {Chang Keun} and Koh, {Young Yull}",

note = "Funding Information: ACKNOWLEDGMENT This study was supported in part by BK 21 Project for Medicine, Dentistry, and Pharmacy, Seoul National University.",

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AU - Yoo, Young

AU - Yu, Jinho

AU - Lee, Sun Hee

AU - Kim, Do Kyun

AU - Choi, Sun Hee

AU - Kim, Chang Keun

AU - Koh, Young Yull

N1 - Funding Information: ACKNOWLEDGMENT This study was supported in part by BK 21 Project for Medicine, Dentistry, and Pharmacy, Seoul National University.

PY - 2007/1

Y1 - 2007/1

N2 - The percentage decrease in forced vital capacity (FVC) at the methacholine PC20 (Δ FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Δ FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (± SD) Δ FVC was significantly (p = 0.001) lower in the CVA group (14.7 ± 3.4%) compared with the CA group (17.1 ± 4.4%), whereas PC20 was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.

AB - The percentage decrease in forced vital capacity (FVC) at the methacholine PC20 (Δ FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Δ FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (± SD) Δ FVC was significantly (p = 0.001) lower in the CVA group (14.7 ± 3.4%) compared with the CA group (17.1 ± 4.4%), whereas PC20 was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.

KW - Classic asthma

KW - Cough-variant asthma

KW - PC

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Comparison of ΔFVC (% decrease in FVC at the PC20) between cough-variant asthma and classic asthma

Abstract

Keywords

ASJC Scopus subject areas

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