Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions: A multicenter study

Seung-Woon Rha, Cheol Ung Choi, Jin Oh Na, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Hyeon Cheol Gwon, Byeong Keuk Kim, Hyo Soo Kim, Cheol Woong Yu, Hun Sik Park, In Ho Chae, Seung Hwan Lee, Moo Hyun Kim, Seung Ho Hur, Young Keun Ahn, Yangsoo Jang

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7 Citations (Scopus)

Abstract

Objective This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. Methods A total of 2865 patients (age 62.82 ± 10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups. Results One year after percutaneous coronary intervention, 241 (8.4%) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023; 7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%, P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008; and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs. Conclusion This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions.

Original languageEnglish
Pages (from-to)699-705
Number of pages7
JournalCoronary Artery Disease
Volume26
Issue number8
DOIs
Publication statusPublished - 2015 Nov 3

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Keywords

  • Chronic total occlusion
  • Diabetic
  • Major adverse cardiac events

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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