Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions: A multicenter study

Seung-Woon Rha, Cheol Ung Choi, Jin Oh Na, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Hyeon Cheol Gwon, Byeong Keuk Kim, Hyo Soo Kim, Cheol Woong Yu, Hun Sik Park, In Ho Chae, Seung Hwan Lee, Moo Hyun Kim, Seung Ho Hur, Young Keun Ahn, Yangsoo Jang

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Abstract

Objective This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. Methods A total of 2865 patients (age 62.82 ± 10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups. Results One year after percutaneous coronary intervention, 241 (8.4%) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023; 7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%, P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008; and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs. Conclusion This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions.

Original languageEnglish
Pages (from-to)699-705
Number of pages7
JournalCoronary Artery Disease
Volume26
Issue number8
DOIs
Publication statusPublished - 2015 Nov 3

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Multicenter Studies
Percutaneous Coronary Intervention
Diabetes Mellitus
Odds Ratio
Insulin
Multivariate Analysis

Keywords

  • Chronic total occlusion
  • Diabetic
  • Major adverse cardiac events

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions : A multicenter study. / Rha, Seung-Woon; Choi, Cheol Ung; Na, Jin Oh; Lim, Hong Euy; Kim, Jin Won; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Gwon, Hyeon Cheol; Kim, Byeong Keuk; Kim, Hyo Soo; Yu, Cheol Woong; Park, Hun Sik; Chae, In Ho; Lee, Seung Hwan; Kim, Moo Hyun; Hur, Seung Ho; Ahn, Young Keun; Jang, Yangsoo.

In: Coronary Artery Disease, Vol. 26, No. 8, 03.11.2015, p. 699-705.

Research output: Contribution to journalArticle

Rha, Seung-Woon ; Choi, Cheol Ung ; Na, Jin Oh ; Lim, Hong Euy ; Kim, Jin Won ; Kim, Eung Ju ; Park, Chang Gyu ; Seo, Hong Seog ; Oh, Dong Joo ; Gwon, Hyeon Cheol ; Kim, Byeong Keuk ; Kim, Hyo Soo ; Yu, Cheol Woong ; Park, Hun Sik ; Chae, In Ho ; Lee, Seung Hwan ; Kim, Moo Hyun ; Hur, Seung Ho ; Ahn, Young Keun ; Jang, Yangsoo. / Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions : A multicenter study. In: Coronary Artery Disease. 2015 ; Vol. 26, No. 8. pp. 699-705.
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abstract = "Objective This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. Methods A total of 2865 patients (age 62.82 ± 10.64 years; 74.0{\%} men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups. Results One year after percutaneous coronary intervention, 241 (8.4{\%}) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9{\%}, P=0.021; 7.2 vs. 4.8{\%}, P=0.023; 7.7 vs. 5.5{\%}, P=0.017; and 10.3 vs. 7.7{\%}, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9{\%}, P=0.018; 11.3 vs. 4.6{\%}, P=0.007; 12.2 vs. 5.9{\%}, P=0.025; 14.8 vs. 5.9{\%}, P=0.003; 16.5 vs. 8.0{\%}, P=0.008; and 17.4 vs. 9.2{\%}, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs. Conclusion This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions.",
keywords = "Chronic total occlusion, Diabetic, Major adverse cardiac events",
author = "Seung-Woon Rha and Choi, {Cheol Ung} and Na, {Jin Oh} and Lim, {Hong Euy} and Kim, {Jin Won} and Kim, {Eung Ju} and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo} and Gwon, {Hyeon Cheol} and Kim, {Byeong Keuk} and Kim, {Hyo Soo} and Yu, {Cheol Woong} and Park, {Hun Sik} and Chae, {In Ho} and Lee, {Seung Hwan} and Kim, {Moo Hyun} and Hur, {Seung Ho} and Ahn, {Young Keun} and Yangsoo Jang",
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TY - JOUR

T1 - Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions

T2 - A multicenter study

AU - Rha, Seung-Woon

AU - Choi, Cheol Ung

AU - Na, Jin Oh

AU - Lim, Hong Euy

AU - Kim, Jin Won

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Gwon, Hyeon Cheol

AU - Kim, Byeong Keuk

AU - Kim, Hyo Soo

AU - Yu, Cheol Woong

AU - Park, Hun Sik

AU - Chae, In Ho

AU - Lee, Seung Hwan

AU - Kim, Moo Hyun

AU - Hur, Seung Ho

AU - Ahn, Young Keun

AU - Jang, Yangsoo

PY - 2015/11/3

Y1 - 2015/11/3

N2 - Objective This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. Methods A total of 2865 patients (age 62.82 ± 10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups. Results One year after percutaneous coronary intervention, 241 (8.4%) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023; 7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%, P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008; and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs. Conclusion This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions.

AB - Objective This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. Methods A total of 2865 patients (age 62.82 ± 10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups. Results One year after percutaneous coronary intervention, 241 (8.4%) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023; 7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%, P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008; and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs. Conclusion This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions.

KW - Chronic total occlusion

KW - Diabetic

KW - Major adverse cardiac events

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