Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: Results from the DIAMOND prospective cohort registry

Ki Bum Won, Seung Ho Hur, Yun Kyeong Cho, Hyuck Jun Yoon, Chang Wook Nam, Kwon Bae Kim, Jang Ho Bae, Dong Ju Choi, Young Keun Ahn, Jong Seon Park, Hyo Soo Kim, Rak Kyeong Choi, Donghoon Choi, Joon Hong Kim, Kyoo Rok Han, Hun Sik Park, So Yeon Choi, Jung Han Yoon, Hyeon Cheol Kwon, Seung-Woon RhaKyung Kuk Hwang, Do-Sun Lim, Kyung Tae Jung, Seok Kyu Oh, Jae Hwan Lee, Eun Seok Shin, Kee Sik Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: After acute myocardial infarction (AMI), the replicated phenomenon of obesity paradox, i.e., obesity appearing to be associated with increased survival, has not been evaluated in stabilized (i.e., without clinical events within 1 month post AMI) Asian patients with diabetes mellitus (DM). Methods: Among 1192 patients in the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry between April 2010 and June 2012, 2-year cardiac and all-cause death were compared according to obesity (body mass index ≥25 kg/m2) in 1125 stabilized DM patients. Results: Compared with non-obese DM patients (62 % of AMI patients), obese DM patients had: higher incidence of dyslipidemia (31 vs. 24 %, P <0.01); lower incidence of chronic kidney disease (26 vs. 33 %) (P <0.01); higher left ventricular ejection fraction after AMI (53 ± 11 vs. 50 ± 12 %, P <0.001); and lower 2-year cardiac and all-cause death occurrence (0.7 vs. 3.6 % and 1.9 vs. 5.2 %, both P <0.01) and cumulative incidence in Kaplan-Meier analysis (P <0.005, respectively). Likewise, both univariate and multivariate Cox hazard regression analyses adjusted for the respective confounders showed that obesity was associated with decreased risk of both cardiac [HR, 0.18 (95 % CI 0.06-0.60), P = 0.005; and 0.24 (0.07-0.78), P = 0.018, respectively] and all-cause death [0.34 (0.16-0.73), P = 0.005; and 0.44 (0.20-0.95), P = 0.038]. Conclusions: In a Korean population of stabilized DM patients after AMI, non-obese patients appear to have higher cardiac and all-cause mortality compared with obese patients after adjusting for confounding factors.

Original languageEnglish
Article number141
JournalCardiovascular Diabetology
Volume14
Issue number1
DOIs
Publication statusPublished - 2015 Oct 15

Keywords

  • Acute myocardial infarction
  • Obesity
  • Survival
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: Results from the DIAMOND prospective cohort registry'. Together they form a unique fingerprint.

  • Cite this

    Won, K. B., Hur, S. H., Cho, Y. K., Yoon, H. J., Nam, C. W., Kim, K. B., Bae, J. H., Choi, D. J., Ahn, Y. K., Park, J. S., Kim, H. S., Choi, R. K., Choi, D., Kim, J. H., Han, K. R., Park, H. S., Choi, S. Y., Yoon, J. H., Kwon, H. C., ... Kim, K. S. (2015). Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: Results from the DIAMOND prospective cohort registry. Cardiovascular Diabetology, 14(1), [141]. https://doi.org/10.1186/s12933-015-0305-1