Comparison of a split-dose bowel preparation with 2 liters of polyethylene glycol plus ascorbic acid and 1 liter of polyethylene glycol plus ascorbic acid and bisacodyl before colonoscopy

Seung Hun Kang, Yoon Tae Jeen, Jae Hyung Lee, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun-Sun Kim, Bora Keum, Hong Sik Lee, Hoon-Jai Chun, Chang Duck Kim

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Background and Aims Recently, a low-volume polyethylene glycol formulation containing ascorbic acid (PEG-Asc) has proven as safe and effective as traditional 4-L PEG solutions for colonoscopy preparation. However, currently available aqueous purgative formulations are poorly tolerated. The aim of this study was to compare a split-dose 2-L PEG-Asc formulation and a 1-L PEG-Asc formulation with bisacodyl (10 mg) to determine the quality of bowel cleansing and patient tolerability. Methods A single-center, randomized, observer-blinded study was performed between May 2015 and September 2015. Two hundred outpatients referred for colonoscopy were prospectively enrolled and assigned to either the split-dose 2-L PEG-Asc group or the 1-L PEG-Asc with bisacodyl 10-mg group. The Boston Bowel Preparation Scale (BBPS) and Aronchick Bowel Preparation Scale (ABPS) were used to evaluate bowel cleansing. The tolerability of the regimens and satisfaction of patients was determined based on a questionnaire. Results Two hundred patients received either 2-L PEG-Asc or 1-L PEG-Asc with bisacodyl. Regarding colon cleansing outcome (BBPS and ABPS), the 1-L PEG-Asc with bisacodyl group showed similar but non-inferior results compared with the 2-L PEG-Asc group on both BBPS (6.92 ± 1.63 vs 6.57 ± 1.37; P =.103) and ABPS (96% vs 95%; P = 1.000) scales. Tolerability was similar for both 1-L PEG-Asc with bisacodyl and 2-L PEG-Asc. Conclusions 1-L PEG-Asc is a suitable alternative to low-volume bowel preparation for colonoscopy. Our study showed that the 1-L PEG-Asc plus bisacodyl preparation has comparable tolerability and results in adequate colon cleansing. Bowel preparation with bisacodyl and 1-L PEG-Asc is a suitable alternative to low-volume bowel preparation for colonoscopy. (Clinical trial registration number: NCT02980562.)

    Original languageEnglish
    Pages (from-to)343-348
    Number of pages6
    JournalGastrointestinal Endoscopy
    Volume86
    Issue number2
    DOIs
    Publication statusPublished - 2017 Aug 1

    Keywords

    • 1-L PEG/AB
    • 1-liter polyethylene glycol with ascorbic acid plus bisacodyl 10 mg
    • 2-L PEG/A
    • 2-liter polyethylene glycol with ascorbic acid
    • ABPS
    • Aronchick Bowel Preparation Scale
    • Asc
    • ascorbic acid
    • BBPS
    • Boston Bowel Preparation Scale
    • PEG
    • polyethylene glycol

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Gastroenterology

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