Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma

Masaki Kaibori, Masanori Kon, Tomoki Kitawaki, Takayuki Kawaura, Kiyoshi Hasegawa, Norihiro Kokudo, Shunichi Ariizumi, Toru Beppu, Hiroyuki Ishizu, Shoji Kubo, Toshiya Kamiyama, Hiroyuki Takamura, Tsuyoshi Kobayashi, Dong-Sik Kim, Hee Jung Wang, Jong Man Kim, Dai Hoon Han, Sang Jae Park, Koo Jeong Kang, Shin HwangYounghoon Roh, Young Kyung You, Jae Won Joh, Masakazu Yamamoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods: To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results: Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28–2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions: Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.

Original languageEnglish
Pages (from-to)616-626
Number of pages11
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume24
Issue number11
DOIs
Publication statusPublished - 2017 Nov 1

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Hepatocellular Carcinoma
Liver
Survival
Recurrence
Disease-Free Survival
Propensity Score
Confounding Factors (Epidemiology)
Korea
Neoplasms
Japan
Confidence Intervals

Keywords

  • Anatomic resection
  • Hepatocellular carcinoma
  • Non-anatomic resection
  • Overall survival

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Cite this

Kaibori, M., Kon, M., Kitawaki, T., Kawaura, T., Hasegawa, K., Kokudo, N., ... Yamamoto, M. (2017). Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma. Journal of Hepato-Biliary-Pancreatic Sciences, 24(11), 616-626. https://doi.org/10.1002/jhbp.502

Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma. / Kaibori, Masaki; Kon, Masanori; Kitawaki, Tomoki; Kawaura, Takayuki; Hasegawa, Kiyoshi; Kokudo, Norihiro; Ariizumi, Shunichi; Beppu, Toru; Ishizu, Hiroyuki; Kubo, Shoji; Kamiyama, Toshiya; Takamura, Hiroyuki; Kobayashi, Tsuyoshi; Kim, Dong-Sik; Wang, Hee Jung; Kim, Jong Man; Han, Dai Hoon; Park, Sang Jae; Kang, Koo Jeong; Hwang, Shin; Roh, Younghoon; You, Young Kyung; Joh, Jae Won; Yamamoto, Masakazu.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 24, No. 11, 01.11.2017, p. 616-626.

Research output: Contribution to journalArticle

Kaibori, M, Kon, M, Kitawaki, T, Kawaura, T, Hasegawa, K, Kokudo, N, Ariizumi, S, Beppu, T, Ishizu, H, Kubo, S, Kamiyama, T, Takamura, H, Kobayashi, T, Kim, D-S, Wang, HJ, Kim, JM, Han, DH, Park, SJ, Kang, KJ, Hwang, S, Roh, Y, You, YK, Joh, JW & Yamamoto, M 2017, 'Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 24, no. 11, pp. 616-626. https://doi.org/10.1002/jhbp.502
Kaibori, Masaki ; Kon, Masanori ; Kitawaki, Tomoki ; Kawaura, Takayuki ; Hasegawa, Kiyoshi ; Kokudo, Norihiro ; Ariizumi, Shunichi ; Beppu, Toru ; Ishizu, Hiroyuki ; Kubo, Shoji ; Kamiyama, Toshiya ; Takamura, Hiroyuki ; Kobayashi, Tsuyoshi ; Kim, Dong-Sik ; Wang, Hee Jung ; Kim, Jong Man ; Han, Dai Hoon ; Park, Sang Jae ; Kang, Koo Jeong ; Hwang, Shin ; Roh, Younghoon ; You, Young Kyung ; Joh, Jae Won ; Yamamoto, Masakazu. / Comparison of anatomic and non-anatomic hepatic resection for hepatocellular carcinoma. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2017 ; Vol. 24, No. 11. pp. 616-626.
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AU - Kaibori, Masaki

AU - Kon, Masanori

AU - Kitawaki, Tomoki

AU - Kawaura, Takayuki

AU - Hasegawa, Kiyoshi

AU - Kokudo, Norihiro

AU - Ariizumi, Shunichi

AU - Beppu, Toru

AU - Ishizu, Hiroyuki

AU - Kubo, Shoji

AU - Kamiyama, Toshiya

AU - Takamura, Hiroyuki

AU - Kobayashi, Tsuyoshi

AU - Kim, Dong-Sik

AU - Wang, Hee Jung

AU - Kim, Jong Man

AU - Han, Dai Hoon

AU - Park, Sang Jae

AU - Kang, Koo Jeong

AU - Hwang, Shin

AU - Roh, Younghoon

AU - You, Young Kyung

AU - Joh, Jae Won

AU - Yamamoto, Masakazu

PY - 2017/11/1

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KW - Anatomic resection

KW - Hepatocellular carcinoma

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KW - Overall survival

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