Comparison of cerebrospinal fluid biomarkers between idiopathic normal pressure hydrocephalus and subarachnoid hemorrhage-induced chronic hydrocephalus: A pilot study

Jeong Hyun Lee, Dong Hyuk Park, Dong Bin Back, Jea Young Lee, Chang In Lee, Kyung Jae Park, Shin Hyuk Kang, Tai Hyoung Cho, Yong Gu Chung

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Abstract

Background: We examined the cerebrospinal fluid (CSF) markers of subarachnoid hemorrhage (SAH)-induced and idiopathic normal pressure hydrocephalus (INPH) to investigate the pathophysiology and mechanism of communicating hydrocephalus compared to obstructive hydrocephalus. Material/Methods: We obtained CSF samples from 8 INPH, 10 SAH-induced hydrocephalus, and 6 unmatched patients with non-hemorrhagic obstructive hydrocephalus during their ventriculoperitoneal shunt operations. Transforming growth factor (TGF)-β1, tumor necrosis factor (TNF)-a, vascular endothelial growth factor (VEGF), and total tau in the CSF were analyzed via enzyme-linked immunosorbent assay. Results: The mean VEGF levels in the CSF of patients with SAH-induced hydrocephalus, INPH, and obstructive hydrocephalus were 239±131, 239±75, and 163±122 pg/mL, respectively. The total tau concentrations in the CSF of the groups were 1139±1900, 325±325, and 1550±2886 pg/mL, respectively. TNF-α values were 114±34, 134±38, and 55±16 pg/mL, respectively. TGF-β1 values were 953±430, 869±447, and 136±63 pg/mL, respectively. A significant difference in TNF-α and TGF-β1 levels was observed only between SAH-induced and chronic obstructive hydrocephalus, and between INPH and chronic obstructive hydrocephalus (p<0.01). Conclusions: No significant differences in the 4 CSF biomarker levels were observed between INPH and SAHinduced hydrocephalus, whereas CSF TNF-α and TGF-β1 levels were increased compared to those in patients with chronic obstructive hydrocephalus. Post-SAH hydrocephalus and INPH are probably more destructive to neural tissues, and then stimulate the inflammatory reaction and healing process, compared with obstructive hydrocephalus.

Original languageEnglish
Pages (from-to)BR19-BR25
JournalMedical Science Monitor
Volume18
Issue number12
Publication statusPublished - 2012 Dec 1

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Keywords

  • Cerebrospinal fluid
  • Normal pressure hydrocephalus
  • Subarachnoid hemorrhage
  • Total tau
  • Transforming growth factor-β1
  • Tumor necrosis factor-α
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine(all)

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