Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era: Analysis of the korean acute myocardial infarction registry

Futoshi Yamanaka, Myung Ho Jeong, Shigeru Saito, Youngkeun Ahn, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, Jei Keon Chae, Jay Young Rhew, In Ho Chae, Myeong Chan Cho, Jang Ho Bae, Seung-Woon Rha, Chong Jin Kim, Donghoon Choi, Yang Soo Jang, Junghan Yoon, Wook Sung ChungJeong Gwan Cho, Ki Bae Seung, Seung Jung Park

Research output: Contribution to journalArticle

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Abstract

Background and purpose: Octogenarians (age. ≥. 80 years) with coronary artery disease constitute a high-risk group. However, octogenarian patients with acute myocardial infarction (AMI) in the drug-eluting stents (DES) era have not been widely reported. We aimed to identify clinical outcomes in octogenarian compared with non-octogenarian AMI patients. Methods and subjects: We retrospectively analyzed 9877 patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and who were enrolled in the Korean Acute Myocardial Infarction Registry (KAMIR). They were divided into 2 groups, octogenarians ( n=. 1494) and non-octogenarians ( n=. 8383), in order to compare the incidence of 1-year all-cause death and 1-year major adverse cardiac events (MACE), where MACE included all-cause death, recurrent myocardial infarction, target vessel revascularization (TVR), target lesion revascularization (TLR), and coronary artery bypass grafting (CABG). Results: The clinical status was significantly inferior in octogenarians compared to non-octogenarians: Killip class. ≥. II (34.8% vs. 22.5%, p<. 0.001), multivessel disease (65.8% vs. 53.7%, p<. 0.001). Rates of 1-year all-cause death were significantly higher in octogenarians than in non-octogenarians (22.3% vs. 6.5%, p<. 0.001). However, the rates of 1-year recurrent myocardial infarction (1.3% vs. 0.9%, p=. 0.68), TLR (2.4% vs. 3.1%, p=. 0.69), TVR (3.6% vs. 4.3%, p=. 0.96), and CABG (0.9% vs. 0.9%, p=. 0.76) did not differ significantly between the 2 groups. Conclusions: Octogenarian AMI patients have higher rates of mortality and MACE even in the DES era. According to KAMIR subgroup analysis, the TLR/TVR rates in octogenarians were comparable to those in non-octogenarian AMI patients.

Original languageEnglish
Pages (from-to)210-216
Number of pages7
JournalJournal of Cardiology
Volume62
Issue number4
DOIs
Publication statusPublished - 2013 Oct 1

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Drug-Eluting Stents
Registries
Myocardial Infarction
Cause of Death
Coronary Artery Bypass
Percutaneous Coronary Intervention
Coronary Artery Disease
Mortality
Incidence

Keywords

  • Elderly
  • Myocardial infarction
  • Prognosis
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era : Analysis of the korean acute myocardial infarction registry. / Yamanaka, Futoshi; Jeong, Myung Ho; Saito, Shigeru; Ahn, Youngkeun; Chae, Shung Chull; Hur, Seung Ho; Hong, Taek Jong; Kim, Young Jo; Seong, In Whan; Chae, Jei Keon; Rhew, Jay Young; Chae, In Ho; Cho, Myeong Chan; Bae, Jang Ho; Rha, Seung-Woon; Kim, Chong Jin; Choi, Donghoon; Jang, Yang Soo; Yoon, Junghan; Chung, Wook Sung; Cho, Jeong Gwan; Seung, Ki Bae; Park, Seung Jung.

In: Journal of Cardiology, Vol. 62, No. 4, 01.10.2013, p. 210-216.

Research output: Contribution to journalArticle

Yamanaka, F, Jeong, MH, Saito, S, Ahn, Y, Chae, SC, Hur, SH, Hong, TJ, Kim, YJ, Seong, IW, Chae, JK, Rhew, JY, Chae, IH, Cho, MC, Bae, JH, Rha, S-W, Kim, CJ, Choi, D, Jang, YS, Yoon, J, Chung, WS, Cho, JG, Seung, KB & Park, SJ 2013, 'Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era: Analysis of the korean acute myocardial infarction registry', Journal of Cardiology, vol. 62, no. 4, pp. 210-216. https://doi.org/10.1016/j.jjcc.2013.04.003
Yamanaka, Futoshi ; Jeong, Myung Ho ; Saito, Shigeru ; Ahn, Youngkeun ; Chae, Shung Chull ; Hur, Seung Ho ; Hong, Taek Jong ; Kim, Young Jo ; Seong, In Whan ; Chae, Jei Keon ; Rhew, Jay Young ; Chae, In Ho ; Cho, Myeong Chan ; Bae, Jang Ho ; Rha, Seung-Woon ; Kim, Chong Jin ; Choi, Donghoon ; Jang, Yang Soo ; Yoon, Junghan ; Chung, Wook Sung ; Cho, Jeong Gwan ; Seung, Ki Bae ; Park, Seung Jung. / Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era : Analysis of the korean acute myocardial infarction registry. In: Journal of Cardiology. 2013 ; Vol. 62, No. 4. pp. 210-216.
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abstract = "Background and purpose: Octogenarians (age. ≥. 80 years) with coronary artery disease constitute a high-risk group. However, octogenarian patients with acute myocardial infarction (AMI) in the drug-eluting stents (DES) era have not been widely reported. We aimed to identify clinical outcomes in octogenarian compared with non-octogenarian AMI patients. Methods and subjects: We retrospectively analyzed 9877 patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and who were enrolled in the Korean Acute Myocardial Infarction Registry (KAMIR). They were divided into 2 groups, octogenarians ( n=. 1494) and non-octogenarians ( n=. 8383), in order to compare the incidence of 1-year all-cause death and 1-year major adverse cardiac events (MACE), where MACE included all-cause death, recurrent myocardial infarction, target vessel revascularization (TVR), target lesion revascularization (TLR), and coronary artery bypass grafting (CABG). Results: The clinical status was significantly inferior in octogenarians compared to non-octogenarians: Killip class. ≥. II (34.8{\%} vs. 22.5{\%}, p<. 0.001), multivessel disease (65.8{\%} vs. 53.7{\%}, p<. 0.001). Rates of 1-year all-cause death were significantly higher in octogenarians than in non-octogenarians (22.3{\%} vs. 6.5{\%}, p<. 0.001). However, the rates of 1-year recurrent myocardial infarction (1.3{\%} vs. 0.9{\%}, p=. 0.68), TLR (2.4{\%} vs. 3.1{\%}, p=. 0.69), TVR (3.6{\%} vs. 4.3{\%}, p=. 0.96), and CABG (0.9{\%} vs. 0.9{\%}, p=. 0.76) did not differ significantly between the 2 groups. Conclusions: Octogenarian AMI patients have higher rates of mortality and MACE even in the DES era. According to KAMIR subgroup analysis, the TLR/TVR rates in octogenarians were comparable to those in non-octogenarian AMI patients.",
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author = "Futoshi Yamanaka and Jeong, {Myung Ho} and Shigeru Saito and Youngkeun Ahn and Chae, {Shung Chull} and Hur, {Seung Ho} and Hong, {Taek Jong} and Kim, {Young Jo} and Seong, {In Whan} and Chae, {Jei Keon} and Rhew, {Jay Young} and Chae, {In Ho} and Cho, {Myeong Chan} and Bae, {Jang Ho} and Seung-Woon Rha and Kim, {Chong Jin} and Donghoon Choi and Jang, {Yang Soo} and Junghan Yoon and Chung, {Wook Sung} and Cho, {Jeong Gwan} and Seung, {Ki Bae} and Park, {Seung Jung}",
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TY - JOUR

T1 - Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era

T2 - Analysis of the korean acute myocardial infarction registry

AU - Yamanaka, Futoshi

AU - Jeong, Myung Ho

AU - Saito, Shigeru

AU - Ahn, Youngkeun

AU - Chae, Shung Chull

AU - Hur, Seung Ho

AU - Hong, Taek Jong

AU - Kim, Young Jo

AU - Seong, In Whan

AU - Chae, Jei Keon

AU - Rhew, Jay Young

AU - Chae, In Ho

AU - Cho, Myeong Chan

AU - Bae, Jang Ho

AU - Rha, Seung-Woon

AU - Kim, Chong Jin

AU - Choi, Donghoon

AU - Jang, Yang Soo

AU - Yoon, Junghan

AU - Chung, Wook Sung

AU - Cho, Jeong Gwan

AU - Seung, Ki Bae

AU - Park, Seung Jung

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Background and purpose: Octogenarians (age. ≥. 80 years) with coronary artery disease constitute a high-risk group. However, octogenarian patients with acute myocardial infarction (AMI) in the drug-eluting stents (DES) era have not been widely reported. We aimed to identify clinical outcomes in octogenarian compared with non-octogenarian AMI patients. Methods and subjects: We retrospectively analyzed 9877 patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and who were enrolled in the Korean Acute Myocardial Infarction Registry (KAMIR). They were divided into 2 groups, octogenarians ( n=. 1494) and non-octogenarians ( n=. 8383), in order to compare the incidence of 1-year all-cause death and 1-year major adverse cardiac events (MACE), where MACE included all-cause death, recurrent myocardial infarction, target vessel revascularization (TVR), target lesion revascularization (TLR), and coronary artery bypass grafting (CABG). Results: The clinical status was significantly inferior in octogenarians compared to non-octogenarians: Killip class. ≥. II (34.8% vs. 22.5%, p<. 0.001), multivessel disease (65.8% vs. 53.7%, p<. 0.001). Rates of 1-year all-cause death were significantly higher in octogenarians than in non-octogenarians (22.3% vs. 6.5%, p<. 0.001). However, the rates of 1-year recurrent myocardial infarction (1.3% vs. 0.9%, p=. 0.68), TLR (2.4% vs. 3.1%, p=. 0.69), TVR (3.6% vs. 4.3%, p=. 0.96), and CABG (0.9% vs. 0.9%, p=. 0.76) did not differ significantly between the 2 groups. Conclusions: Octogenarian AMI patients have higher rates of mortality and MACE even in the DES era. According to KAMIR subgroup analysis, the TLR/TVR rates in octogenarians were comparable to those in non-octogenarian AMI patients.

AB - Background and purpose: Octogenarians (age. ≥. 80 years) with coronary artery disease constitute a high-risk group. However, octogenarian patients with acute myocardial infarction (AMI) in the drug-eluting stents (DES) era have not been widely reported. We aimed to identify clinical outcomes in octogenarian compared with non-octogenarian AMI patients. Methods and subjects: We retrospectively analyzed 9877 patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and who were enrolled in the Korean Acute Myocardial Infarction Registry (KAMIR). They were divided into 2 groups, octogenarians ( n=. 1494) and non-octogenarians ( n=. 8383), in order to compare the incidence of 1-year all-cause death and 1-year major adverse cardiac events (MACE), where MACE included all-cause death, recurrent myocardial infarction, target vessel revascularization (TVR), target lesion revascularization (TLR), and coronary artery bypass grafting (CABG). Results: The clinical status was significantly inferior in octogenarians compared to non-octogenarians: Killip class. ≥. II (34.8% vs. 22.5%, p<. 0.001), multivessel disease (65.8% vs. 53.7%, p<. 0.001). Rates of 1-year all-cause death were significantly higher in octogenarians than in non-octogenarians (22.3% vs. 6.5%, p<. 0.001). However, the rates of 1-year recurrent myocardial infarction (1.3% vs. 0.9%, p=. 0.68), TLR (2.4% vs. 3.1%, p=. 0.69), TVR (3.6% vs. 4.3%, p=. 0.96), and CABG (0.9% vs. 0.9%, p=. 0.76) did not differ significantly between the 2 groups. Conclusions: Octogenarian AMI patients have higher rates of mortality and MACE even in the DES era. According to KAMIR subgroup analysis, the TLR/TVR rates in octogenarians were comparable to those in non-octogenarian AMI patients.

KW - Elderly

KW - Myocardial infarction

KW - Prognosis

KW - Treatment

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DO - 10.1016/j.jjcc.2013.04.003

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