Comparison of clinical outcomes of adenocarcinoma and adenosquamous carcinoma in uterine cervical cancer patients receiving surgical resection followed by radiotherapy: A multicenter retrospective study (KROG 13-10)

Jae Myoung Noh, Won Park, Young Seok Kim, Joo Young Kim, Hak Jae Kim, Juree Kim, Jin Hee Kim, Mee Sun Yoon, Jin Hwa Choi, Won Sup Yoon, Ji Yoon Kim, Seung Jae Huh

    Research output: Contribution to journalArticlepeer-review

    58 Citations (Scopus)

    Abstract

    Objective To evaluate the prognostic influence of adenocarcinoma (AC) and adenosquamous carcinoma (ASC) in patients with FIGO stage IB-IIA cervical cancer who received radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). Methods We analyzed 1323 patients who satisfied the following criteria: histologically proven squamous cell carcinoma (SCC), AC, or ASC of the uterine cervix; FIGO stage IB-IIA disease; no history of neoadjuvant chemotherapy; and a history of radical hysterectomy with pelvic lymph node (PLN) dissection, followed by postoperative pelvic RT at a dose ≥ 45 Gy. The median age was 50 years. Median RT dose delivered to the whole pelvis was 50.4 Gy, and 219 (16.6%) patients received brachytherapy at a median dose of 24 Gy. Concurrent chemotherapy was delivered to 492 (37.2%) patients. Results Pathologic risk factors were not different according to pathologic subtype. The median follow-up duration was 75.7 months. Locoregional recurrence-free survival, relapse-free survival (RFS), and overall survival were significantly affected by histology, tumor size, PLN metastasis, parametrial invasion, lymphovascular invasion, and deep stromal invasion. The 5-year RFS rates were 83.7%, 66.5%, and 79.6% in patients with SCC, AC, and ASC histology, respectively (P < 0.0001). By multivariate analysis, AC histology was the only significant prognostic factor affecting all survival outcomes. Conclusions AC histology was associated with poor survival outcomes in patients with FIGO stage IB-IIA cervical cancer who received adjuvant RT or CCRT. Prognosis of ASC histology was closer to that of SCC histology than that of AC histology.

    Original languageEnglish
    Pages (from-to)618-623
    Number of pages6
    JournalGynecologic Oncology
    Volume132
    Issue number3
    DOIs
    Publication statusPublished - 2014 Mar

    Keywords

    • Adenocarcinoma
    • Adenosquamous carcinoma
    • Cervical cancer
    • Postoperative radiotherapy

    ASJC Scopus subject areas

    • Oncology
    • Obstetrics and Gynaecology

    Fingerprint

    Dive into the research topics of 'Comparison of clinical outcomes of adenocarcinoma and adenosquamous carcinoma in uterine cervical cancer patients receiving surgical resection followed by radiotherapy: A multicenter retrospective study (KROG 13-10)'. Together they form a unique fingerprint.

    Cite this