Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: Systematic review and meta-analysis

Jun H. Kim, Kyung H. Lee, Kyoung Tae Kim, Hyun J. Kim, Hyeong Sik Ahn, Yeo J. Kim, Ha Y. Lee, Yong S. Jeon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To compare the diagnostic accuracy of digital tomosynthesis (DTS) with that of chest radiography for the detection of pulmonary nodules by meta-analysis. Methods: A systematic literature search was performed to identify relevant original studies from 1 January 1 1976 to 31 August 31 2016. The quality of included studies was assessed by quality assessment of diagnostic accuracy studies-2. Per-patient data were used to calculate the sensitivity and specificity and per-lesion data were used to calculate the detection rate. Summary receiveroperating characteristic curves were drawn for pulmonary nodule detection. Results: 16 studies met the inclusion criteria. 1017 patients on a per-patient basis and 2159 lesions on a per-lesion basis from 16 eligible studies were evaluated. The pooled patient-based sensitivity of DTS was 0.85 [95% confidence interval (CI) 0.83-0.88] and the specificity was 0.95 (0.93-0.96). The pooled sensitivity and specificity of chest radiography were 0.47 (0.44-0.51) and 0.37 (0.34-0.40), respectively. The per-lesion detection rate was 2.90 (95% CI 2.63-3.19). Conclusion: DTS has higher diagnostic accuracy than chest radiography for detection of pulmonary nodules. Chest radiography has low sensitivity but similar specificity, comparable with that of DTS.

Original languageEnglish
Article number0421
JournalBritish Journal of Radiology
Volume89
Issue number1068
DOIs
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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