Comparison of hand-assisted laparoscopic radical nephrectomy with open radical nephrectomy for pT1-2 clear cell renal-cell carcinoma

A multi-institutional study

Yong Hyun Park, Seok Soo Byun, Seok Ho Kang, Jun Sung Koh, Hyoung Keun Park, Sung Hyun Paick, Young Jin Seo, Tag Geun Yoo, Han Jung, Jin Seon Cho, Seong Soo Jeon, Yunhee Choi, Sue Kyung Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: This multiinstitutional report assesses the oncologic efficacy of hand-assisted laparoscopic radical nephrectomy (HLRN) compared with open radical nephrectomy (ORN) in patients with localized clear cell renal-cell carcinoma (RCC). Patients and Methods: We analyzed the data from 2561 patients who underwent radical nephrectomy at 26 institutions in Korea between June 1998 and December 2007 for localized RCC. One hundred ninety-seven patients with clear cell RCC in the HLRN group were compared with 917 patients with clear cell RCC in the ORN group. To evaluate the technical adequacy and oncologic outcome, we compared the operative time, estimated blood loss, and 5-year overall and disease-free survival rates. Results: The median follow-up was 36 months for the HLRN group and 27 months for the ORN group. The operative time was significantly longer in the HLRN group than in the ORN group (206.8±68.7 minutes vs. 179.1±61.5 minutes, p<0.001), and blood loss was significantly lower in the HLRN group than in the ORN group (311.6±238. 7mL vs. 372.4±367.3mL, p=0.003). There was no significant difference in pathologic T stage and Fuhrman's nuclear grade in the two groups. No statistically significant difference was found in the 5-year overall (91.2% vs. 90.3%, p=0.286) and disease-specific (95.2% vs. 92.1%, p=0.222) survival rates between the HLRN and ORN groups. Conclusions: Despite the longer operative time, HLRN was an effective and less-invasive treatment option for localized clear cell RCC. HLRN could achieve cancer control similar to that obtained with ORN.

Original languageEnglish
Pages (from-to)1485-1489
Number of pages5
JournalJournal of Endourology
Volume23
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

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Nephrectomy
Renal Cell Carcinoma
Hand
Operative Time
Survival Rate
Korea
Disease-Free Survival

ASJC Scopus subject areas

  • Urology

Cite this

Comparison of hand-assisted laparoscopic radical nephrectomy with open radical nephrectomy for pT1-2 clear cell renal-cell carcinoma : A multi-institutional study. / Park, Yong Hyun; Byun, Seok Soo; Kang, Seok Ho; Koh, Jun Sung; Park, Hyoung Keun; Paick, Sung Hyun; Seo, Young Jin; Yoo, Tag Geun; Jung, Han; Cho, Jin Seon; Jeon, Seong Soo; Choi, Yunhee; Park, Sue Kyung.

In: Journal of Endourology, Vol. 23, No. 9, 01.09.2009, p. 1485-1489.

Research output: Contribution to journalArticle

Park, YH, Byun, SS, Kang, SH, Koh, JS, Park, HK, Paick, SH, Seo, YJ, Yoo, TG, Jung, H, Cho, JS, Jeon, SS, Choi, Y & Park, SK 2009, 'Comparison of hand-assisted laparoscopic radical nephrectomy with open radical nephrectomy for pT1-2 clear cell renal-cell carcinoma: A multi-institutional study', Journal of Endourology, vol. 23, no. 9, pp. 1485-1489. https://doi.org/10.1089/end.2009.0375
Park, Yong Hyun ; Byun, Seok Soo ; Kang, Seok Ho ; Koh, Jun Sung ; Park, Hyoung Keun ; Paick, Sung Hyun ; Seo, Young Jin ; Yoo, Tag Geun ; Jung, Han ; Cho, Jin Seon ; Jeon, Seong Soo ; Choi, Yunhee ; Park, Sue Kyung. / Comparison of hand-assisted laparoscopic radical nephrectomy with open radical nephrectomy for pT1-2 clear cell renal-cell carcinoma : A multi-institutional study. In: Journal of Endourology. 2009 ; Vol. 23, No. 9. pp. 1485-1489.
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abstract = "Purpose: This multiinstitutional report assesses the oncologic efficacy of hand-assisted laparoscopic radical nephrectomy (HLRN) compared with open radical nephrectomy (ORN) in patients with localized clear cell renal-cell carcinoma (RCC). Patients and Methods: We analyzed the data from 2561 patients who underwent radical nephrectomy at 26 institutions in Korea between June 1998 and December 2007 for localized RCC. One hundred ninety-seven patients with clear cell RCC in the HLRN group were compared with 917 patients with clear cell RCC in the ORN group. To evaluate the technical adequacy and oncologic outcome, we compared the operative time, estimated blood loss, and 5-year overall and disease-free survival rates. Results: The median follow-up was 36 months for the HLRN group and 27 months for the ORN group. The operative time was significantly longer in the HLRN group than in the ORN group (206.8±68.7 minutes vs. 179.1±61.5 minutes, p<0.001), and blood loss was significantly lower in the HLRN group than in the ORN group (311.6±238. 7mL vs. 372.4±367.3mL, p=0.003). There was no significant difference in pathologic T stage and Fuhrman's nuclear grade in the two groups. No statistically significant difference was found in the 5-year overall (91.2{\%} vs. 90.3{\%}, p=0.286) and disease-specific (95.2{\%} vs. 92.1{\%}, p=0.222) survival rates between the HLRN and ORN groups. Conclusions: Despite the longer operative time, HLRN was an effective and less-invasive treatment option for localized clear cell RCC. HLRN could achieve cancer control similar to that obtained with ORN.",
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T1 - Comparison of hand-assisted laparoscopic radical nephrectomy with open radical nephrectomy for pT1-2 clear cell renal-cell carcinoma

T2 - A multi-institutional study

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AU - Byun, Seok Soo

AU - Kang, Seok Ho

AU - Koh, Jun Sung

AU - Park, Hyoung Keun

AU - Paick, Sung Hyun

AU - Seo, Young Jin

AU - Yoo, Tag Geun

AU - Jung, Han

AU - Cho, Jin Seon

AU - Jeon, Seong Soo

AU - Choi, Yunhee

AU - Park, Sue Kyung

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N2 - Purpose: This multiinstitutional report assesses the oncologic efficacy of hand-assisted laparoscopic radical nephrectomy (HLRN) compared with open radical nephrectomy (ORN) in patients with localized clear cell renal-cell carcinoma (RCC). Patients and Methods: We analyzed the data from 2561 patients who underwent radical nephrectomy at 26 institutions in Korea between June 1998 and December 2007 for localized RCC. One hundred ninety-seven patients with clear cell RCC in the HLRN group were compared with 917 patients with clear cell RCC in the ORN group. To evaluate the technical adequacy and oncologic outcome, we compared the operative time, estimated blood loss, and 5-year overall and disease-free survival rates. Results: The median follow-up was 36 months for the HLRN group and 27 months for the ORN group. The operative time was significantly longer in the HLRN group than in the ORN group (206.8±68.7 minutes vs. 179.1±61.5 minutes, p<0.001), and blood loss was significantly lower in the HLRN group than in the ORN group (311.6±238. 7mL vs. 372.4±367.3mL, p=0.003). There was no significant difference in pathologic T stage and Fuhrman's nuclear grade in the two groups. No statistically significant difference was found in the 5-year overall (91.2% vs. 90.3%, p=0.286) and disease-specific (95.2% vs. 92.1%, p=0.222) survival rates between the HLRN and ORN groups. Conclusions: Despite the longer operative time, HLRN was an effective and less-invasive treatment option for localized clear cell RCC. HLRN could achieve cancer control similar to that obtained with ORN.

AB - Purpose: This multiinstitutional report assesses the oncologic efficacy of hand-assisted laparoscopic radical nephrectomy (HLRN) compared with open radical nephrectomy (ORN) in patients with localized clear cell renal-cell carcinoma (RCC). Patients and Methods: We analyzed the data from 2561 patients who underwent radical nephrectomy at 26 institutions in Korea between June 1998 and December 2007 for localized RCC. One hundred ninety-seven patients with clear cell RCC in the HLRN group were compared with 917 patients with clear cell RCC in the ORN group. To evaluate the technical adequacy and oncologic outcome, we compared the operative time, estimated blood loss, and 5-year overall and disease-free survival rates. Results: The median follow-up was 36 months for the HLRN group and 27 months for the ORN group. The operative time was significantly longer in the HLRN group than in the ORN group (206.8±68.7 minutes vs. 179.1±61.5 minutes, p<0.001), and blood loss was significantly lower in the HLRN group than in the ORN group (311.6±238. 7mL vs. 372.4±367.3mL, p=0.003). There was no significant difference in pathologic T stage and Fuhrman's nuclear grade in the two groups. No statistically significant difference was found in the 5-year overall (91.2% vs. 90.3%, p=0.286) and disease-specific (95.2% vs. 92.1%, p=0.222) survival rates between the HLRN and ORN groups. Conclusions: Despite the longer operative time, HLRN was an effective and less-invasive treatment option for localized clear cell RCC. HLRN could achieve cancer control similar to that obtained with ORN.

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