Comparison of inflammatory markers between diabetic and nondiabetic ST segment elevation myocardial infarction

Ji Man Heo, Jae Hyoung Park, Ju Hyeon Kim, Sung Hae You, Je Sang Kim, Chul Min Ahn, Soon Jun Hong, Kyung Ho Shin, Do-Sun Lim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Inflammation plays a significant role in acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM). There may be similar inflammatory changes in non-DM patients with ST elevation myocardial infarction (STEMI) and DM patients with stable angina (SA), and DM patients with STEMI may have more severe changes than the former two groups. The objectives of this study were to investigate whether the level of inflammation was similar in patients with non-DM STEMI and DM SA, and to evaluate whether the changes in the level of inflammation were more severe in patients with DM STEMI compared to the other two groups. Methods and results: A variety of inflammatory markers including: highly sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), IL-18, vascular cell adhesion molecule-1 (VCAM-1), and matrix metallopeptidase-9 (MMP-9) as well as insulin resistance were compared among the three groups: DM STEMI (90 patients), DM SA (91 patients), and non-DM STEMI (76 patients). Inflammatory marker levels were not significantly different between the DM SA and non-DM STEMI groups. However, hsCRP and IL-6 were increased in the DM STEMI compared to the DM SA patients (p= 0.005 and p= 0.004, respectively). In addition, hsCRP, ESR, and IL-18 were increased in the DM STEMI compared to the non-DM STEMI patients (p= 0.017, p= 0.020, and p= 0.033, respectively). Furthermore, the fasting insulin and the homeostasis model assessment were significantly increased in the DM STEMI compared to the DM SA patients (p= 0.04 and p= 0.004, respectively). Conclusions: DM SA and non-DM STEMI may have similar inflammatory changes. DM STEMI may be a more severe inflammatory condition compared to patients with DM SA or non-DM STEMI.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalJournal of Cardiology
Volume60
Issue number3
DOIs
Publication statusPublished - 2012 Sep 1

Fingerprint

Diabetes Mellitus
Stable Angina
C-Reactive Protein
Interleukin-18
Blood Sedimentation
ST Elevation Myocardial Infarction
Inflammation
Type 2 Diabetes Mellitus
Interleukin-6
Vascular Cell Adhesion Molecule-1
Metalloproteases
Acute Coronary Syndrome
Insulin Resistance
Fasting
Homeostasis
Insulin

Keywords

  • Diabetes mellitus
  • Inflammatory markers
  • ST elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of inflammatory markers between diabetic and nondiabetic ST segment elevation myocardial infarction. / Heo, Ji Man; Park, Jae Hyoung; Kim, Ju Hyeon; You, Sung Hae; Kim, Je Sang; Ahn, Chul Min; Hong, Soon Jun; Shin, Kyung Ho; Lim, Do-Sun.

In: Journal of Cardiology, Vol. 60, No. 3, 01.09.2012, p. 204-209.

Research output: Contribution to journalArticle

Heo, Ji Man ; Park, Jae Hyoung ; Kim, Ju Hyeon ; You, Sung Hae ; Kim, Je Sang ; Ahn, Chul Min ; Hong, Soon Jun ; Shin, Kyung Ho ; Lim, Do-Sun. / Comparison of inflammatory markers between diabetic and nondiabetic ST segment elevation myocardial infarction. In: Journal of Cardiology. 2012 ; Vol. 60, No. 3. pp. 204-209.
@article{e2ad660c564e4cceafe04f37218baa82,
title = "Comparison of inflammatory markers between diabetic and nondiabetic ST segment elevation myocardial infarction",
abstract = "Background: Inflammation plays a significant role in acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM). There may be similar inflammatory changes in non-DM patients with ST elevation myocardial infarction (STEMI) and DM patients with stable angina (SA), and DM patients with STEMI may have more severe changes than the former two groups. The objectives of this study were to investigate whether the level of inflammation was similar in patients with non-DM STEMI and DM SA, and to evaluate whether the changes in the level of inflammation were more severe in patients with DM STEMI compared to the other two groups. Methods and results: A variety of inflammatory markers including: highly sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), IL-18, vascular cell adhesion molecule-1 (VCAM-1), and matrix metallopeptidase-9 (MMP-9) as well as insulin resistance were compared among the three groups: DM STEMI (90 patients), DM SA (91 patients), and non-DM STEMI (76 patients). Inflammatory marker levels were not significantly different between the DM SA and non-DM STEMI groups. However, hsCRP and IL-6 were increased in the DM STEMI compared to the DM SA patients (p= 0.005 and p= 0.004, respectively). In addition, hsCRP, ESR, and IL-18 were increased in the DM STEMI compared to the non-DM STEMI patients (p= 0.017, p= 0.020, and p= 0.033, respectively). Furthermore, the fasting insulin and the homeostasis model assessment were significantly increased in the DM STEMI compared to the DM SA patients (p= 0.04 and p= 0.004, respectively). Conclusions: DM SA and non-DM STEMI may have similar inflammatory changes. DM STEMI may be a more severe inflammatory condition compared to patients with DM SA or non-DM STEMI.",
keywords = "Diabetes mellitus, Inflammatory markers, ST elevation myocardial infarction",
author = "Heo, {Ji Man} and Park, {Jae Hyoung} and Kim, {Ju Hyeon} and You, {Sung Hae} and Kim, {Je Sang} and Ahn, {Chul Min} and Hong, {Soon Jun} and Shin, {Kyung Ho} and Do-Sun Lim",
year = "2012",
month = "9",
day = "1",
doi = "10.1016/j.jjcc.2012.03.006",
language = "English",
volume = "60",
pages = "204--209",
journal = "Journal of Cardiology",
issn = "0914-5087",
publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",
number = "3",

}

TY - JOUR

T1 - Comparison of inflammatory markers between diabetic and nondiabetic ST segment elevation myocardial infarction

AU - Heo, Ji Man

AU - Park, Jae Hyoung

AU - Kim, Ju Hyeon

AU - You, Sung Hae

AU - Kim, Je Sang

AU - Ahn, Chul Min

AU - Hong, Soon Jun

AU - Shin, Kyung Ho

AU - Lim, Do-Sun

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: Inflammation plays a significant role in acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM). There may be similar inflammatory changes in non-DM patients with ST elevation myocardial infarction (STEMI) and DM patients with stable angina (SA), and DM patients with STEMI may have more severe changes than the former two groups. The objectives of this study were to investigate whether the level of inflammation was similar in patients with non-DM STEMI and DM SA, and to evaluate whether the changes in the level of inflammation were more severe in patients with DM STEMI compared to the other two groups. Methods and results: A variety of inflammatory markers including: highly sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), IL-18, vascular cell adhesion molecule-1 (VCAM-1), and matrix metallopeptidase-9 (MMP-9) as well as insulin resistance were compared among the three groups: DM STEMI (90 patients), DM SA (91 patients), and non-DM STEMI (76 patients). Inflammatory marker levels were not significantly different between the DM SA and non-DM STEMI groups. However, hsCRP and IL-6 were increased in the DM STEMI compared to the DM SA patients (p= 0.005 and p= 0.004, respectively). In addition, hsCRP, ESR, and IL-18 were increased in the DM STEMI compared to the non-DM STEMI patients (p= 0.017, p= 0.020, and p= 0.033, respectively). Furthermore, the fasting insulin and the homeostasis model assessment were significantly increased in the DM STEMI compared to the DM SA patients (p= 0.04 and p= 0.004, respectively). Conclusions: DM SA and non-DM STEMI may have similar inflammatory changes. DM STEMI may be a more severe inflammatory condition compared to patients with DM SA or non-DM STEMI.

AB - Background: Inflammation plays a significant role in acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM). There may be similar inflammatory changes in non-DM patients with ST elevation myocardial infarction (STEMI) and DM patients with stable angina (SA), and DM patients with STEMI may have more severe changes than the former two groups. The objectives of this study were to investigate whether the level of inflammation was similar in patients with non-DM STEMI and DM SA, and to evaluate whether the changes in the level of inflammation were more severe in patients with DM STEMI compared to the other two groups. Methods and results: A variety of inflammatory markers including: highly sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), IL-18, vascular cell adhesion molecule-1 (VCAM-1), and matrix metallopeptidase-9 (MMP-9) as well as insulin resistance were compared among the three groups: DM STEMI (90 patients), DM SA (91 patients), and non-DM STEMI (76 patients). Inflammatory marker levels were not significantly different between the DM SA and non-DM STEMI groups. However, hsCRP and IL-6 were increased in the DM STEMI compared to the DM SA patients (p= 0.005 and p= 0.004, respectively). In addition, hsCRP, ESR, and IL-18 were increased in the DM STEMI compared to the non-DM STEMI patients (p= 0.017, p= 0.020, and p= 0.033, respectively). Furthermore, the fasting insulin and the homeostasis model assessment were significantly increased in the DM STEMI compared to the DM SA patients (p= 0.04 and p= 0.004, respectively). Conclusions: DM SA and non-DM STEMI may have similar inflammatory changes. DM STEMI may be a more severe inflammatory condition compared to patients with DM SA or non-DM STEMI.

KW - Diabetes mellitus

KW - Inflammatory markers

KW - ST elevation myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=84866176803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866176803&partnerID=8YFLogxK

U2 - 10.1016/j.jjcc.2012.03.006

DO - 10.1016/j.jjcc.2012.03.006

M3 - Article

VL - 60

SP - 204

EP - 209

JO - Journal of Cardiology

JF - Journal of Cardiology

SN - 0914-5087

IS - 3

ER -