Comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro

So Hee Shim, Man-Seong Park, Sungsil Moon, Kwang Sook Park, Jin Won Song, Ki-Joon Song, Luck Ju Baek

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Hantaviruses are human pathogens that cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. The mechanisms accounting for the differences in virulence between pathogenic and non-pathogenic hantaviruses are not well known. We have examined the pathogenesis of different hantavirus groups by comparing the innate immune responses induced in the host cell following infection by pathogenic (Sin Nombre, Hantaan, and Seoul virus) and putative non-pathogenic (Prospect Hill, Tula, and Thottapalayam virus) hantaviruses. Pathogenic hantaviruses were found to replicate more efficiently in interferon-competent A549 cells than putative non-pathogenic hantaviruses. The former also suppressed the expression of the interferon-β and myxovirus resistance protein genes, while the transcription level of both genes increased rapidly within 24 h post-infection in the latter. In addition, the induction level of interferon correlated with the activation level of interferon regulatory factor-3. Taken together, these results suggest that the observed differences are correlated with viral pathogenesis and further indicate that pathogenic and putative non-pathogenic hantaviruses differ in terms of early interferon induction via activation of the interferon regulatory factor-3 in infected host cells.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalVirus Research
Volume160
Issue number1-2
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Hantavirus
Innate Immunity
Interferons
Interferon Regulatory Factor-3
Seoul virus
Sin Nombre virus
Myxovirus Resistance Proteins
Hantaan virus
Hemorrhagic Fever with Renal Syndrome
In Vitro Techniques
Infection
Genes
Virulence
Viruses

Keywords

  • Innate immunity
  • Pathogenic hantaviruses
  • Putative non-pathogenic hantaviruses
  • Type-I interferon

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro. / Shim, So Hee; Park, Man-Seong; Moon, Sungsil; Park, Kwang Sook; Song, Jin Won; Song, Ki-Joon; Baek, Luck Ju.

In: Virus Research, Vol. 160, No. 1-2, 01.09.2011, p. 367-373.

Research output: Contribution to journalArticle

Shim, So Hee ; Park, Man-Seong ; Moon, Sungsil ; Park, Kwang Sook ; Song, Jin Won ; Song, Ki-Joon ; Baek, Luck Ju. / Comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro. In: Virus Research. 2011 ; Vol. 160, No. 1-2. pp. 367-373.
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