Comparison of lactate threshold, glucose, and insulin levels between OLETF and LETO rats after all-out exercise

Hyukki Chang, Jae Young Park, Min Hwa Suk, Ho Jun Lee, Hyun Joo Kang, Kyung Mook Choi, Wook Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Otsuka Long-Evans Tokushima Fatty (OLETF) rats are an animal model for obesity and Non Insulin Dependent Diabetes Mellitus by hyperphagia. The lactate threshold (LT) is used to determinate aerobic capacity and exercise intensity in individuals. The purpose of this study was to determine whether velocity at the LT (VLT), glucose, and insulin levels of OLETF differs from Long-Evans Tokushima (LETO) rats after all-out exercise on treadmill running. In the results, we found that VLT level of OLETF rats (17.8 ± 1.39 m·min-1) was significantly lower than that of the LETO rats (20.5 ± 1.33 m·min-1). The blood glucose levels immediately after all-out exercise increased in OLETF (from 7.23 ± 0.36 to 9.38 ± 1.77 mmol·L-1) and decreased in LETO rats (from 6.36 ± 0.27 to 4.42 ± 0.71 mmol·L-1), and the insulin level was decreased in both the OLETF (from 34.4 ± 7.7 to 20.13 ± 8.63 μU·ml-1) and LETO (from 15.29 ± 2.6 to 5.72 ± 1.49 μU·ml-1) rats immediately after the all-out exercise, but the difference was not significant. Our results suggest that the different VLT, blood glucose and insulin levels should be considered to compensate for the differences between the OLETF and LETO rats. Moreover, the VLT will be a useful reference for the future studies on exercise training of OLETF rats.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalJournal of Sports Science and Medicine
Volume8
Issue number3
Publication statusPublished - 2009 Sep 1

Fingerprint

Long Evans Rats
Inbred OLETF Rats
Lactic Acid
Insulin
Glucose
Blood Glucose
Exercise
Hyperphagia
Running
Type 2 Diabetes Mellitus
Animal Models
Obesity

Keywords

  • All-out exercise
  • Lactate
  • NIDDM
  • OLETF
  • Treadmill running
  • Velocity of lactate threshold

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Comparison of lactate threshold, glucose, and insulin levels between OLETF and LETO rats after all-out exercise. / Chang, Hyukki; Park, Jae Young; Suk, Min Hwa; Lee, Ho Jun; Kang, Hyun Joo; Choi, Kyung Mook; Song, Wook.

In: Journal of Sports Science and Medicine, Vol. 8, No. 3, 01.09.2009, p. 381-387.

Research output: Contribution to journalArticle

Chang, Hyukki ; Park, Jae Young ; Suk, Min Hwa ; Lee, Ho Jun ; Kang, Hyun Joo ; Choi, Kyung Mook ; Song, Wook. / Comparison of lactate threshold, glucose, and insulin levels between OLETF and LETO rats after all-out exercise. In: Journal of Sports Science and Medicine. 2009 ; Vol. 8, No. 3. pp. 381-387.
@article{6fc6a4950ff94d1bbb393e7b4ac4c964,
title = "Comparison of lactate threshold, glucose, and insulin levels between OLETF and LETO rats after all-out exercise",
abstract = "Otsuka Long-Evans Tokushima Fatty (OLETF) rats are an animal model for obesity and Non Insulin Dependent Diabetes Mellitus by hyperphagia. The lactate threshold (LT) is used to determinate aerobic capacity and exercise intensity in individuals. The purpose of this study was to determine whether velocity at the LT (VLT), glucose, and insulin levels of OLETF differs from Long-Evans Tokushima (LETO) rats after all-out exercise on treadmill running. In the results, we found that VLT level of OLETF rats (17.8 ± 1.39 m·min-1) was significantly lower than that of the LETO rats (20.5 ± 1.33 m·min-1). The blood glucose levels immediately after all-out exercise increased in OLETF (from 7.23 ± 0.36 to 9.38 ± 1.77 mmol·L-1) and decreased in LETO rats (from 6.36 ± 0.27 to 4.42 ± 0.71 mmol·L-1), and the insulin level was decreased in both the OLETF (from 34.4 ± 7.7 to 20.13 ± 8.63 μU·ml-1) and LETO (from 15.29 ± 2.6 to 5.72 ± 1.49 μU·ml-1) rats immediately after the all-out exercise, but the difference was not significant. Our results suggest that the different VLT, blood glucose and insulin levels should be considered to compensate for the differences between the OLETF and LETO rats. Moreover, the VLT will be a useful reference for the future studies on exercise training of OLETF rats.",
keywords = "All-out exercise, Lactate, NIDDM, OLETF, Treadmill running, Velocity of lactate threshold",
author = "Hyukki Chang and Park, {Jae Young} and Suk, {Min Hwa} and Lee, {Ho Jun} and Kang, {Hyun Joo} and Choi, {Kyung Mook} and Wook Song",
year = "2009",
month = "9",
day = "1",
language = "English",
volume = "8",
pages = "381--387",
journal = "Journal of Sports Science and Medicine",
issn = "1303-2968",
publisher = "Department of Sports Medicine, Medical Faculty of Uludag University",
number = "3",

}

TY - JOUR

T1 - Comparison of lactate threshold, glucose, and insulin levels between OLETF and LETO rats after all-out exercise

AU - Chang, Hyukki

AU - Park, Jae Young

AU - Suk, Min Hwa

AU - Lee, Ho Jun

AU - Kang, Hyun Joo

AU - Choi, Kyung Mook

AU - Song, Wook

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Otsuka Long-Evans Tokushima Fatty (OLETF) rats are an animal model for obesity and Non Insulin Dependent Diabetes Mellitus by hyperphagia. The lactate threshold (LT) is used to determinate aerobic capacity and exercise intensity in individuals. The purpose of this study was to determine whether velocity at the LT (VLT), glucose, and insulin levels of OLETF differs from Long-Evans Tokushima (LETO) rats after all-out exercise on treadmill running. In the results, we found that VLT level of OLETF rats (17.8 ± 1.39 m·min-1) was significantly lower than that of the LETO rats (20.5 ± 1.33 m·min-1). The blood glucose levels immediately after all-out exercise increased in OLETF (from 7.23 ± 0.36 to 9.38 ± 1.77 mmol·L-1) and decreased in LETO rats (from 6.36 ± 0.27 to 4.42 ± 0.71 mmol·L-1), and the insulin level was decreased in both the OLETF (from 34.4 ± 7.7 to 20.13 ± 8.63 μU·ml-1) and LETO (from 15.29 ± 2.6 to 5.72 ± 1.49 μU·ml-1) rats immediately after the all-out exercise, but the difference was not significant. Our results suggest that the different VLT, blood glucose and insulin levels should be considered to compensate for the differences between the OLETF and LETO rats. Moreover, the VLT will be a useful reference for the future studies on exercise training of OLETF rats.

AB - Otsuka Long-Evans Tokushima Fatty (OLETF) rats are an animal model for obesity and Non Insulin Dependent Diabetes Mellitus by hyperphagia. The lactate threshold (LT) is used to determinate aerobic capacity and exercise intensity in individuals. The purpose of this study was to determine whether velocity at the LT (VLT), glucose, and insulin levels of OLETF differs from Long-Evans Tokushima (LETO) rats after all-out exercise on treadmill running. In the results, we found that VLT level of OLETF rats (17.8 ± 1.39 m·min-1) was significantly lower than that of the LETO rats (20.5 ± 1.33 m·min-1). The blood glucose levels immediately after all-out exercise increased in OLETF (from 7.23 ± 0.36 to 9.38 ± 1.77 mmol·L-1) and decreased in LETO rats (from 6.36 ± 0.27 to 4.42 ± 0.71 mmol·L-1), and the insulin level was decreased in both the OLETF (from 34.4 ± 7.7 to 20.13 ± 8.63 μU·ml-1) and LETO (from 15.29 ± 2.6 to 5.72 ± 1.49 μU·ml-1) rats immediately after the all-out exercise, but the difference was not significant. Our results suggest that the different VLT, blood glucose and insulin levels should be considered to compensate for the differences between the OLETF and LETO rats. Moreover, the VLT will be a useful reference for the future studies on exercise training of OLETF rats.

KW - All-out exercise

KW - Lactate

KW - NIDDM

KW - OLETF

KW - Treadmill running

KW - Velocity of lactate threshold

UR - http://www.scopus.com/inward/record.url?scp=70349314394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349314394&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 381

EP - 387

JO - Journal of Sports Science and Medicine

JF - Journal of Sports Science and Medicine

SN - 1303-2968

IS - 3

ER -