Comparison of low vs moderate dose of atorvastatin in clopidogrel resistance after coronary stenting in Korean patients with acute coronary syndrome

Soon Jun Hong, Ji Young Park, Kyoung Ah Kim, Chul Min Ahn, Jae Suk Park, Yong Hyun Kim, Wan Joo Shim, Seong Mi Park, Do Sun Lim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The effect of atorvastatin 10 mg vs 40 mg in clopidogrel resistance and clinical events after coronary stenting was compared in patients with acute coronary syndrome (ACS). Methods and Results: Platelet aggregation was measured before clopidogrel administration and 4h, 24 h, 5 days, and 8 months later in 130 ACS patients. Stented patients were randomly assigned to atorvastatin either 10 mg (n=65) or 40 mg (n=65), and received an oral loading dose of 300 mg of clopidogrel followed by 75 mg/day for 8 months. Measurement of platelet aggregation was done by the turbimetric method. The mean % changes in inhibition of platelet aggregation were 35.5±8.3, 50.9±10.1, 38.3±8.3, 40.0±6.8 in the Atorvastatin 10 mg Group and 31.0±7.6, 43.7±9.8, 45.0±10.3, 43.5±7.8 (4 h, 24 h, 5 days, and 8 months, respectively, after 300 mg of clopidogrel pretreatment) in the Atorvastatin 40 mg Group with no significant differences between the 2 groups. Cardiovascular events showed no significant differences during the follow-up. Conclusions: Atorvastatin 10 mg or 40 mg co-administered with clopidogrel for 8 months did not affect the anti-platelet potency of clopidogrel and showed no significant differences in the clinical events in ACS patients.

Original languageEnglish
Pages (from-to)1111-1118
Number of pages8
JournalCirculation Journal
Volume73
Issue number6
DOIs
Publication statusPublished - 2009 Jun

Keywords

  • Acute coronary syndrome
  • Atorvastatin
  • Clopidogrel

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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