Comparison of myocardial loading between asynchronous pulsatile and nonpulsatile percutaneous extracorporeal life support

Jeong Jin Yu, Ho Sung Son, Choon Hak Lim, Jung Joo Lee, Young Woo Park, Keun Her, Yong Soon Won, Kyung Sun, Jung Yun Choi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We hypothesized that myocardial loading can be increased when extracorporeal pulse flow occurs during systole, and that this may adversely affect myocardial working conditions in heart failure patients supported by extracorporeal life support (ECLS). This study was designed to compare myocardial loading and myocardial oxygen consumption/supply balance between nonpulsatile ECLS and asynchronized pulsatile ECLS in a myocardial stunning model. Thirteen, 23-42 kg dogs were allotted to a nonpulsatile group and an asynchronous pulsatile group. Coronary sinus lactate level, mixed venous oxygen consumption (MvO2), and left anterior descending coronary artery flow were measured. The real-time pressure of the left ventricle and the ascending aorta was monitored, and the lowest left ventricular pressure and tension time index were calculated. Our results showed that the lactate level and the lowest left ventricular pressure were lower in the pulsatile group than in the nonpulsatile group at 30 minutes after ECLS was applicated (p < 0.05, respectively). Tension time index in the pulsatile ECLS group was substantially lower than in the nonpulsatile group. Left anterior descending coronary flow did not show significant difference between the two groups. In conclusion, asynchronous pulsatile ECLS may also be superior to nonpulsatile ECLS in myocardial volume unloading and oxygen consumption/supply balance.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalASAIO Journal
Volume54
Issue number2
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

Extracorporeal Membrane Oxygenation
Oxygen
Lactic Acid
Oxygen Consumption
Unloading
Ventricular Pressure
Myocardial Stunning
Coronary Sinus
Self-Help Groups
Systole
Heart Ventricles
Pulse
Aorta
Coronary Vessels
Heart Failure
Dogs

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Comparison of myocardial loading between asynchronous pulsatile and nonpulsatile percutaneous extracorporeal life support. / Yu, Jeong Jin; Son, Ho Sung; Lim, Choon Hak; Lee, Jung Joo; Park, Young Woo; Her, Keun; Won, Yong Soon; Sun, Kyung; Choi, Jung Yun.

In: ASAIO Journal, Vol. 54, No. 2, 01.03.2008, p. 177-180.

Research output: Contribution to journalArticle

Yu, Jeong Jin ; Son, Ho Sung ; Lim, Choon Hak ; Lee, Jung Joo ; Park, Young Woo ; Her, Keun ; Won, Yong Soon ; Sun, Kyung ; Choi, Jung Yun. / Comparison of myocardial loading between asynchronous pulsatile and nonpulsatile percutaneous extracorporeal life support. In: ASAIO Journal. 2008 ; Vol. 54, No. 2. pp. 177-180.
@article{ef789abe85d441c79cfe09aea4837623,
title = "Comparison of myocardial loading between asynchronous pulsatile and nonpulsatile percutaneous extracorporeal life support",
abstract = "We hypothesized that myocardial loading can be increased when extracorporeal pulse flow occurs during systole, and that this may adversely affect myocardial working conditions in heart failure patients supported by extracorporeal life support (ECLS). This study was designed to compare myocardial loading and myocardial oxygen consumption/supply balance between nonpulsatile ECLS and asynchronized pulsatile ECLS in a myocardial stunning model. Thirteen, 23-42 kg dogs were allotted to a nonpulsatile group and an asynchronous pulsatile group. Coronary sinus lactate level, mixed venous oxygen consumption (MvO2), and left anterior descending coronary artery flow were measured. The real-time pressure of the left ventricle and the ascending aorta was monitored, and the lowest left ventricular pressure and tension time index were calculated. Our results showed that the lactate level and the lowest left ventricular pressure were lower in the pulsatile group than in the nonpulsatile group at 30 minutes after ECLS was applicated (p < 0.05, respectively). Tension time index in the pulsatile ECLS group was substantially lower than in the nonpulsatile group. Left anterior descending coronary flow did not show significant difference between the two groups. In conclusion, asynchronous pulsatile ECLS may also be superior to nonpulsatile ECLS in myocardial volume unloading and oxygen consumption/supply balance.",
author = "Yu, {Jeong Jin} and Son, {Ho Sung} and Lim, {Choon Hak} and Lee, {Jung Joo} and Park, {Young Woo} and Keun Her and Won, {Yong Soon} and Kyung Sun and Choi, {Jung Yun}",
year = "2008",
month = "3",
day = "1",
doi = "10.1097/MAT.0b013e318165f512",
language = "English",
volume = "54",
pages = "177--180",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Comparison of myocardial loading between asynchronous pulsatile and nonpulsatile percutaneous extracorporeal life support

AU - Yu, Jeong Jin

AU - Son, Ho Sung

AU - Lim, Choon Hak

AU - Lee, Jung Joo

AU - Park, Young Woo

AU - Her, Keun

AU - Won, Yong Soon

AU - Sun, Kyung

AU - Choi, Jung Yun

PY - 2008/3/1

Y1 - 2008/3/1

N2 - We hypothesized that myocardial loading can be increased when extracorporeal pulse flow occurs during systole, and that this may adversely affect myocardial working conditions in heart failure patients supported by extracorporeal life support (ECLS). This study was designed to compare myocardial loading and myocardial oxygen consumption/supply balance between nonpulsatile ECLS and asynchronized pulsatile ECLS in a myocardial stunning model. Thirteen, 23-42 kg dogs were allotted to a nonpulsatile group and an asynchronous pulsatile group. Coronary sinus lactate level, mixed venous oxygen consumption (MvO2), and left anterior descending coronary artery flow were measured. The real-time pressure of the left ventricle and the ascending aorta was monitored, and the lowest left ventricular pressure and tension time index were calculated. Our results showed that the lactate level and the lowest left ventricular pressure were lower in the pulsatile group than in the nonpulsatile group at 30 minutes after ECLS was applicated (p < 0.05, respectively). Tension time index in the pulsatile ECLS group was substantially lower than in the nonpulsatile group. Left anterior descending coronary flow did not show significant difference between the two groups. In conclusion, asynchronous pulsatile ECLS may also be superior to nonpulsatile ECLS in myocardial volume unloading and oxygen consumption/supply balance.

AB - We hypothesized that myocardial loading can be increased when extracorporeal pulse flow occurs during systole, and that this may adversely affect myocardial working conditions in heart failure patients supported by extracorporeal life support (ECLS). This study was designed to compare myocardial loading and myocardial oxygen consumption/supply balance between nonpulsatile ECLS and asynchronized pulsatile ECLS in a myocardial stunning model. Thirteen, 23-42 kg dogs were allotted to a nonpulsatile group and an asynchronous pulsatile group. Coronary sinus lactate level, mixed venous oxygen consumption (MvO2), and left anterior descending coronary artery flow were measured. The real-time pressure of the left ventricle and the ascending aorta was monitored, and the lowest left ventricular pressure and tension time index were calculated. Our results showed that the lactate level and the lowest left ventricular pressure were lower in the pulsatile group than in the nonpulsatile group at 30 minutes after ECLS was applicated (p < 0.05, respectively). Tension time index in the pulsatile ECLS group was substantially lower than in the nonpulsatile group. Left anterior descending coronary flow did not show significant difference between the two groups. In conclusion, asynchronous pulsatile ECLS may also be superior to nonpulsatile ECLS in myocardial volume unloading and oxygen consumption/supply balance.

UR - http://www.scopus.com/inward/record.url?scp=41349110033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41349110033&partnerID=8YFLogxK

U2 - 10.1097/MAT.0b013e318165f512

DO - 10.1097/MAT.0b013e318165f512

M3 - Article

C2 - 18356651

AN - SCOPUS:41349110033

VL - 54

SP - 177

EP - 180

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 2

ER -