Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 between patients with asymptomatic bronchial hyperresponsiveness and mild asthma

Young Yoo, Ji-Tae Choung, Jinho Yu, Kyun Kim Do, Hee Choi Sun, Yull Koh Young

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20). The percentage fall in FVC at the PC20 (ΔFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC20. The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to ΔFVC. Methods: Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC 20 < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC20 were selected (mild asthma group). The ΔFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups. Results: There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (± SD) ΔFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 ± 3.6%) than in the mild asthma group (16.9 ± 4.3%). Conclusions: Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalChest
Volume132
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

Fingerprint

Methacholine Chloride
Asthma
Bronchial Diseases
Bronchial Provocation Tests
Eosinophils
Immunoglobulin E
Siblings
Serum

Keywords

  • Asymptomatic bronchial hyperresponsiveness
  • Maximal airway response
  • Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 between patients with asymptomatic bronchial hyperresponsiveness and mild asthma. / Yoo, Young; Choung, Ji-Tae; Yu, Jinho; Do, Kyun Kim; Sun, Hee Choi; Young, Yull Koh.

In: Chest, Vol. 132, No. 1, 01.01.2007, p. 106-111.

Research output: Contribution to journalArticle

@article{56020ca582e44246af044c4e8cb42ecd,
title = "Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20{\%} fall in FEV1 between patients with asymptomatic bronchial hyperresponsiveness and mild asthma",
abstract = "Background: A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20{\%} fall in FEV1 (PC20). The percentage fall in FVC at the PC20 (ΔFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC20. The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to ΔFVC. Methods: Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC 20 < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC20 were selected (mild asthma group). The ΔFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups. Results: There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (± SD) ΔFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 ± 3.6{\%}) than in the mild asthma group (16.9 ± 4.3{\%}). Conclusions: Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR.",
keywords = "Asymptomatic bronchial hyperresponsiveness, Maximal airway response, Percentage fall in FVC at the provocative concentration of methacholine causing a 20{\%} fall in FEV",
author = "Young Yoo and Ji-Tae Choung and Jinho Yu and Do, {Kyun Kim} and Sun, {Hee Choi} and Young, {Yull Koh}",
year = "2007",
month = "1",
day = "1",
doi = "10.1378/chest.06-2943",
language = "English",
volume = "132",
pages = "106--111",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

TY - JOUR

T1 - Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 between patients with asymptomatic bronchial hyperresponsiveness and mild asthma

AU - Yoo, Young

AU - Choung, Ji-Tae

AU - Yu, Jinho

AU - Do, Kyun Kim

AU - Sun, Hee Choi

AU - Young, Yull Koh

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background: A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20). The percentage fall in FVC at the PC20 (ΔFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC20. The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to ΔFVC. Methods: Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC 20 < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC20 were selected (mild asthma group). The ΔFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups. Results: There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (± SD) ΔFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 ± 3.6%) than in the mild asthma group (16.9 ± 4.3%). Conclusions: Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR.

AB - Background: A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20). The percentage fall in FVC at the PC20 (ΔFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC20. The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to ΔFVC. Methods: Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC 20 < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC20 were selected (mild asthma group). The ΔFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups. Results: There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (± SD) ΔFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 ± 3.6%) than in the mild asthma group (16.9 ± 4.3%). Conclusions: Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR.

KW - Asymptomatic bronchial hyperresponsiveness

KW - Maximal airway response

KW - Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV

UR - http://www.scopus.com/inward/record.url?scp=34447505155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447505155&partnerID=8YFLogxK

U2 - 10.1378/chest.06-2943

DO - 10.1378/chest.06-2943

M3 - Article

VL - 132

SP - 106

EP - 111

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -