Abstract
Aim: To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. Methods: A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) were randomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method, and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. Results: A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall, bleeding complications occurred in 7.6% (37/486) of the patients, including 4.9% (12/244) in the epinephrine group, and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients, respectively, including 4.5% (11/244), 0.4% (1/244) in the epinephrine group, and 8.7% (21/242), 1.7% (4/242) in the saline group. No significant differences in the rates of overall, early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. Conclusion: The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB.
| Original language | English |
|---|---|
| Pages (from-to) | 2973-2977 |
| Number of pages | 5 |
| Journal | World Journal of Gastroenterology |
| Volume | 13 |
| Issue number | 21 |
| Publication status | Published - 2007 Jun 7 |
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Keywords
- Bleeding
- Colonoscopic polypectomy
- Epinephrine
- Saline
- Submucosal injection
ASJC Scopus subject areas
- Gastroenterology
Cite this
Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy : A prospective randomized, multicenter study. / Lee, Suck Ho; Chung, Il Kwun; Kim, Sun Joo; Kim, Jin Oh; Ko, Bong Min; Kim, Won Ho; Kim, Hyun Soo; Park, Dong Il; Kim, Hyo Jong; Byeon, Jeong Sik; Yang, Suk Kyun; Jang, Byeong Ik; Jung, Sung Ae; Jeen, Yoon Tae; Choi, Jai Hyun; Choi, Hwang; Han, Dong Soo; Song, Jae Suk.
In: World Journal of Gastroenterology, Vol. 13, No. 21, 07.06.2007, p. 2973-2977.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy
T2 - A prospective randomized, multicenter study
AU - Lee, Suck Ho
AU - Chung, Il Kwun
AU - Kim, Sun Joo
AU - Kim, Jin Oh
AU - Ko, Bong Min
AU - Kim, Won Ho
AU - Kim, Hyun Soo
AU - Park, Dong Il
AU - Kim, Hyo Jong
AU - Byeon, Jeong Sik
AU - Yang, Suk Kyun
AU - Jang, Byeong Ik
AU - Jung, Sung Ae
AU - Jeen, Yoon Tae
AU - Choi, Jai Hyun
AU - Choi, Hwang
AU - Han, Dong Soo
AU - Song, Jae Suk
PY - 2007/6/7
Y1 - 2007/6/7
N2 - Aim: To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. Methods: A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) were randomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method, and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. Results: A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall, bleeding complications occurred in 7.6% (37/486) of the patients, including 4.9% (12/244) in the epinephrine group, and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients, respectively, including 4.5% (11/244), 0.4% (1/244) in the epinephrine group, and 8.7% (21/242), 1.7% (4/242) in the saline group. No significant differences in the rates of overall, early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. Conclusion: The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB.
AB - Aim: To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. Methods: A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) were randomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method, and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. Results: A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall, bleeding complications occurred in 7.6% (37/486) of the patients, including 4.9% (12/244) in the epinephrine group, and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients, respectively, including 4.5% (11/244), 0.4% (1/244) in the epinephrine group, and 8.7% (21/242), 1.7% (4/242) in the saline group. No significant differences in the rates of overall, early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. Conclusion: The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB.
KW - Bleeding
KW - Colonoscopic polypectomy
KW - Epinephrine
KW - Saline
KW - Submucosal injection
UR - http://www.scopus.com/inward/record.url?scp=34447102816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447102816&partnerID=8YFLogxK
M3 - Article
C2 - 17589949
AN - SCOPUS:34447102816
VL - 13
SP - 2973
EP - 2977
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 21
ER -