Comparison of Resolute zotarolimus-eluting and Xience everolimus-eluting stents in patients with de novo long coronary artery lesions: A randomized LONG-DES VI trial

Do Yoon Kang, Cheol Hyun Lee, Pil Hyung Lee, Jung Min Ahn, Seung Whan Lee, Young Hak Kim, Seong Wook Park, Chang Wook Nam, Yun Seok Choi, Seung-Woon Rha, Jang Hyun Cho, Weon Kim, Sung Ho Her, Myung Ho Jeong, Joo Young Yang, Bong Ki Lee, Hun Sik Park, Duk Woo Park, Seung Jung Park

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Abstract

Background Outcomes for stent-based coronary intervention of lesions with long diseased segments remain relatively unfavorable. This study sought to compare the efficacy of Resolute zotarolimus-eluting stents (R-ZES) and Xience everolimus-eluting stents (EES) for very long coronary lesions. Methods and results This randomized, multicenter, prospective trial compared the use of R-ZES with EES for very long (≥50 mm) native coronary lesions. The primary end point was in-segment late luminal loss at 12-month angiographic follow-up. A total of 400 patients were needed to assess the primary end point. However, owing to very slow enrollment of patients, this trial was early terminated (302 patients were enrolled), and thus, this report provides descriptive information on primary and secondary end points. The R-ZES and EES groups had similar baseline characteristics. Lesion length was 49.6±10.2 and 50.6±13.3 mm in the R-ZES and EES groups, respectively (P=0.47). The number of stents used at the target lesion was 2.1±0.3 and 2.2±0.5, respectively. Twelve-month angiographic follow-up was performed in 50% of eligible patients. In-segment late luminal loss did not significantly differ between the R-ZES and EES groups (0.17±0.57 vs. 0.09±0.43 mm, P=0.32). In-segment binary restenosis rates were 8.1 and 5.3% in the R-ZES and EES groups, respectively (P=0.49). There were no significant between-group differences in the rate of adverse events (death, myocardial infarction, stent thrombosis, target lesion revascularization, and composite outcomes). Conclusion For patients with very long native coronary artery disease, R-ZES and EES implantation showed comparable angiographic and clinical outcomes through 1 year of follow-up.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalCoronary Artery Disease
Volume30
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • angioplasty
  • coronary disease
  • stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Kang, D. Y., Lee, C. H., Lee, P. H., Ahn, J. M., Lee, S. W., Kim, Y. H., Park, S. W., Nam, C. W., Choi, Y. S., Rha, S-W., Cho, J. H., Kim, W., Her, S. H., Jeong, M. H., Yang, J. Y., Lee, B. K., Park, H. S., Park, D. W., & Park, S. J. (2019). Comparison of Resolute zotarolimus-eluting and Xience everolimus-eluting stents in patients with de novo long coronary artery lesions: A randomized LONG-DES VI trial. Coronary Artery Disease, 30(1), 59-66. https://doi.org/10.1097/MCA.0000000000000680