Comparison of Retinal Vessel Diameter Between Open-Angle Glaucoma Patients With Initial Parafoveal Scotoma and Peripheral Nasal Step

Eunjoo Yoo, Chungkwon Yoo, Tae Eun Lee, Yong Yeon Kim

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2 Citations (Scopus)

Abstract

Purpose To compare retinal vessel diameters (RVDs) between open-angle glaucoma (OAG) patients with initial parafoveal scotoma (PFS) and those with initial peripheral nasal step (PNS). Design Retrospective, cross-sectional study. Methods We enrolled 151 eyes of 151 patients with OAG (83 with normal-tension glaucoma [NTG] and 68 with primary open-angle glaucoma [POAG]). The patients were categorized into the PFS and PNS groups according to the location of the initial visual field (VF) defect. Clinical characteristics and RVD indices—central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE)—were compared between the groups. Subgroup analyses were conducted in the NTG and POAG groups. Results Forty-six patients had PFS and 105 had PNS. The CRAE of the PFS group was significantly lower than that of the PNS group in all glaucoma patients (P = .001). However, neither the mean deviation in VF nor that in the average retinal nerve fiber layer thickness showed significant intergroup differences. In the NTG subgroup analysis, the CRAE of the PFS group was significantly lower than that of the PNS group (P = .013). Conversely, in the POAG subgroup analysis, the CRAE in the PFS group did not differ significantly from that in the PNS group (P = .123). Conclusions Retinal arteriolar diameter was narrower in OAG patients with initial PFS than in those with initial PNS, especially in the NTG group. This suggests that the initial location of the VF defect may be associated with the vascular mechanism in patients with glaucoma.

Original languageEnglish
Pages (from-to)30-36
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume175
DOIs
Publication statusPublished - 2017 Mar 1

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Scotoma
Retinal Vessels
Open Angle Glaucoma
Nose
Low Tension Glaucoma
Visual Fields
Glaucoma
Nerve Fibers
Blood Vessels
Cross-Sectional Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Comparison of Retinal Vessel Diameter Between Open-Angle Glaucoma Patients With Initial Parafoveal Scotoma and Peripheral Nasal Step",
abstract = "Purpose To compare retinal vessel diameters (RVDs) between open-angle glaucoma (OAG) patients with initial parafoveal scotoma (PFS) and those with initial peripheral nasal step (PNS). Design Retrospective, cross-sectional study. Methods We enrolled 151 eyes of 151 patients with OAG (83 with normal-tension glaucoma [NTG] and 68 with primary open-angle glaucoma [POAG]). The patients were categorized into the PFS and PNS groups according to the location of the initial visual field (VF) defect. Clinical characteristics and RVD indices—central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE)—were compared between the groups. Subgroup analyses were conducted in the NTG and POAG groups. Results Forty-six patients had PFS and 105 had PNS. The CRAE of the PFS group was significantly lower than that of the PNS group in all glaucoma patients (P = .001). However, neither the mean deviation in VF nor that in the average retinal nerve fiber layer thickness showed significant intergroup differences. In the NTG subgroup analysis, the CRAE of the PFS group was significantly lower than that of the PNS group (P = .013). Conversely, in the POAG subgroup analysis, the CRAE in the PFS group did not differ significantly from that in the PNS group (P = .123). Conclusions Retinal arteriolar diameter was narrower in OAG patients with initial PFS than in those with initial PNS, especially in the NTG group. This suggests that the initial location of the VF defect may be associated with the vascular mechanism in patients with glaucoma.",
author = "Eunjoo Yoo and Chungkwon Yoo and Lee, {Tae Eun} and Kim, {Yong Yeon}",
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T1 - Comparison of Retinal Vessel Diameter Between Open-Angle Glaucoma Patients With Initial Parafoveal Scotoma and Peripheral Nasal Step

AU - Yoo, Eunjoo

AU - Yoo, Chungkwon

AU - Lee, Tae Eun

AU - Kim, Yong Yeon

PY - 2017/3/1

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N2 - Purpose To compare retinal vessel diameters (RVDs) between open-angle glaucoma (OAG) patients with initial parafoveal scotoma (PFS) and those with initial peripheral nasal step (PNS). Design Retrospective, cross-sectional study. Methods We enrolled 151 eyes of 151 patients with OAG (83 with normal-tension glaucoma [NTG] and 68 with primary open-angle glaucoma [POAG]). The patients were categorized into the PFS and PNS groups according to the location of the initial visual field (VF) defect. Clinical characteristics and RVD indices—central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE)—were compared between the groups. Subgroup analyses were conducted in the NTG and POAG groups. Results Forty-six patients had PFS and 105 had PNS. The CRAE of the PFS group was significantly lower than that of the PNS group in all glaucoma patients (P = .001). However, neither the mean deviation in VF nor that in the average retinal nerve fiber layer thickness showed significant intergroup differences. In the NTG subgroup analysis, the CRAE of the PFS group was significantly lower than that of the PNS group (P = .013). Conversely, in the POAG subgroup analysis, the CRAE in the PFS group did not differ significantly from that in the PNS group (P = .123). Conclusions Retinal arteriolar diameter was narrower in OAG patients with initial PFS than in those with initial PNS, especially in the NTG group. This suggests that the initial location of the VF defect may be associated with the vascular mechanism in patients with glaucoma.

AB - Purpose To compare retinal vessel diameters (RVDs) between open-angle glaucoma (OAG) patients with initial parafoveal scotoma (PFS) and those with initial peripheral nasal step (PNS). Design Retrospective, cross-sectional study. Methods We enrolled 151 eyes of 151 patients with OAG (83 with normal-tension glaucoma [NTG] and 68 with primary open-angle glaucoma [POAG]). The patients were categorized into the PFS and PNS groups according to the location of the initial visual field (VF) defect. Clinical characteristics and RVD indices—central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE)—were compared between the groups. Subgroup analyses were conducted in the NTG and POAG groups. Results Forty-six patients had PFS and 105 had PNS. The CRAE of the PFS group was significantly lower than that of the PNS group in all glaucoma patients (P = .001). However, neither the mean deviation in VF nor that in the average retinal nerve fiber layer thickness showed significant intergroup differences. In the NTG subgroup analysis, the CRAE of the PFS group was significantly lower than that of the PNS group (P = .013). Conversely, in the POAG subgroup analysis, the CRAE in the PFS group did not differ significantly from that in the PNS group (P = .123). Conclusions Retinal arteriolar diameter was narrower in OAG patients with initial PFS than in those with initial PNS, especially in the NTG group. This suggests that the initial location of the VF defect may be associated with the vascular mechanism in patients with glaucoma.

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