Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection

Hyuk Soon Choi, Hoon Jai Chun, Sang Hoon Park, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Soon Ho Um, Hong Sik Lee, Chang Duck Kim, Ho Sang Ryu

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.

Original languageEnglish
Pages (from-to)2377-2382
Number of pages6
JournalWorld journal of gastroenterology
Volume18
Issue number19
DOIs
Publication statusPublished - 2012 May 21

Keywords

  • Duodenal ulcer
  • Gastric ulcer
  • Gastritis
  • Helicobacter pylori
  • Sequential therapy
  • Triple therapy

ASJC Scopus subject areas

  • Gastroenterology

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