Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection

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Abstract

AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.

Original languageEnglish
Pages (from-to)2377-2382
Number of pages6
JournalWorld Journal of Gastroenterology
Volume18
Issue number19
DOIs
Publication statusPublished - 2012 May 21

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Helicobacter Infections
Helicobacter pylori
Therapeutics
Intention to Treat Analysis
Breath Tests
Gastritis
Stomach Ulcer
Duodenal Ulcer
Urea
Histology

Keywords

  • Duodenal ulcer
  • Gastric ulcer
  • Gastritis
  • Helicobacter pylori
  • Sequential therapy
  • Triple therapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection",
abstract = "AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0{\%}, and eradication rates were 75.7{\%} for 7-d conventional triple therapy, 81.9{\%} for 10-d conventional triple therapy, 84.4{\%} for 14-d conventional triple therapy, and 82.0{\%} for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.",
keywords = "Duodenal ulcer, Gastric ulcer, Gastritis, Helicobacter pylori, Sequential therapy, Triple therapy",
author = "Choi, {Hyuk Soon} and Hoon-Jai Chun and Park, {Sang Hoon} and Bora Keum and Seo, {Yeon Seok} and Kim, {Yong Sik} and Jeen, {Yoon Tae} and Soon-Ho Um and Lee, {Hong Sik} and Kim, {Chang Duck} and Ryu, {Ho Sang}",
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T1 - Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection

AU - Choi, Hyuk Soon

AU - Chun, Hoon-Jai

AU - Park, Sang Hoon

AU - Keum, Bora

AU - Seo, Yeon Seok

AU - Kim, Yong Sik

AU - Jeen, Yoon Tae

AU - Um, Soon-Ho

AU - Lee, Hong Sik

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

PY - 2012/5/21

Y1 - 2012/5/21

N2 - AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.

AB - AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.

KW - Duodenal ulcer

KW - Gastric ulcer

KW - Gastritis

KW - Helicobacter pylori

KW - Sequential therapy

KW - Triple therapy

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