Abstract
Background: Although structural alterations have been reported in patients with major depressive disorder (MDD), very few studies have compared the shape alterations of the subcortical regions between drug-naïve MDD patients and healthy controls (HCs). Therefore, we investigated and compared the subcortical shape alterations and volumetric changes between drug-naïve MDD patients and HCs in this study. Methods: This study included 45 drug-naïve MDD patients and 83 HCs, who underwent three-dimensional (3-D) T1-weighted structural magnetic resonance imaging. Surface-based vertex analysis (SVA) was performed with automated segmentation of the bilateral caudate nuclei, putamina, nuclei accumbens, thalami, pallidum, hippocampi, amygdalae, and brainstem. SVA revealed regional contractions of the thalamus (bilateral medial and lateral nuclei) and right caudate nucleus (medial wall and anterosuperior areas) in the drug-naïve MDD patients when compared to HCs Results: In volume analysis, the drug-naïve MDD patients showed a significant decrease in the volume of bilateral thalami compared with HCs (after Bonferroni correction p < 0.003). We identified morphometric contractions in bilateral thalami and right caudate nucleus in the drug-naïve MDD patients (p < 0.05). Conclusions: The present study implied that with cortical shape changes, the subcortical brain alterations could contribute to emotional dysregulation in the drug-naïve MDD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 279-285 |
| Number of pages | 7 |
| Journal | Journal of Affective Disorders |
| Volume | 264 |
| DOIs | |
| Publication status | Published - 2020 Mar 1 |
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Keywords
- Caudate nucleus
- Magnetic resonance imaging
- Major depressive disorder
- Subcortical region
- Thalamus
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Comparison of shape alterations of the thalamus and caudate nucleus between drug-naïve major depressive disorder patients and healthy controls. / Choi, Kwan Woo; Han, Kyu Man; Kim, Hyun; Kim, Aram; Kang, Wooyoung; Kang, Youbin; Tae, Woo Suk; Ham, Byung Joo.
In: Journal of Affective Disorders, Vol. 264, 01.03.2020, p. 279-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of shape alterations of the thalamus and caudate nucleus between drug-naïve major depressive disorder patients and healthy controls
AU - Choi, Kwan Woo
AU - Han, Kyu Man
AU - Kim, Hyun
AU - Kim, Aram
AU - Kang, Wooyoung
AU - Kang, Youbin
AU - Tae, Woo Suk
AU - Ham, Byung Joo
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Background: Although structural alterations have been reported in patients with major depressive disorder (MDD), very few studies have compared the shape alterations of the subcortical regions between drug-naïve MDD patients and healthy controls (HCs). Therefore, we investigated and compared the subcortical shape alterations and volumetric changes between drug-naïve MDD patients and HCs in this study. Methods: This study included 45 drug-naïve MDD patients and 83 HCs, who underwent three-dimensional (3-D) T1-weighted structural magnetic resonance imaging. Surface-based vertex analysis (SVA) was performed with automated segmentation of the bilateral caudate nuclei, putamina, nuclei accumbens, thalami, pallidum, hippocampi, amygdalae, and brainstem. SVA revealed regional contractions of the thalamus (bilateral medial and lateral nuclei) and right caudate nucleus (medial wall and anterosuperior areas) in the drug-naïve MDD patients when compared to HCs Results: In volume analysis, the drug-naïve MDD patients showed a significant decrease in the volume of bilateral thalami compared with HCs (after Bonferroni correction p < 0.003). We identified morphometric contractions in bilateral thalami and right caudate nucleus in the drug-naïve MDD patients (p < 0.05). Conclusions: The present study implied that with cortical shape changes, the subcortical brain alterations could contribute to emotional dysregulation in the drug-naïve MDD patients.
AB - Background: Although structural alterations have been reported in patients with major depressive disorder (MDD), very few studies have compared the shape alterations of the subcortical regions between drug-naïve MDD patients and healthy controls (HCs). Therefore, we investigated and compared the subcortical shape alterations and volumetric changes between drug-naïve MDD patients and HCs in this study. Methods: This study included 45 drug-naïve MDD patients and 83 HCs, who underwent three-dimensional (3-D) T1-weighted structural magnetic resonance imaging. Surface-based vertex analysis (SVA) was performed with automated segmentation of the bilateral caudate nuclei, putamina, nuclei accumbens, thalami, pallidum, hippocampi, amygdalae, and brainstem. SVA revealed regional contractions of the thalamus (bilateral medial and lateral nuclei) and right caudate nucleus (medial wall and anterosuperior areas) in the drug-naïve MDD patients when compared to HCs Results: In volume analysis, the drug-naïve MDD patients showed a significant decrease in the volume of bilateral thalami compared with HCs (after Bonferroni correction p < 0.003). We identified morphometric contractions in bilateral thalami and right caudate nucleus in the drug-naïve MDD patients (p < 0.05). Conclusions: The present study implied that with cortical shape changes, the subcortical brain alterations could contribute to emotional dysregulation in the drug-naïve MDD patients.
KW - Caudate nucleus
KW - Magnetic resonance imaging
KW - Major depressive disorder
KW - Subcortical region
KW - Thalamus
UR - http://www.scopus.com/inward/record.url?scp=85077643179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077643179&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2020.01.011
DO - 10.1016/j.jad.2020.01.011
M3 - Article
AN - SCOPUS:85077643179
VL - 264
SP - 279
EP - 285
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -