Comparison of shape alterations of the thalamus and caudate nucleus between drug-naïve major depressive disorder patients and healthy controls

Kwan Woo Choi, Kyu Man Han, Hyun Kim, Aram Kim, Wooyoung Kang, Youbin Kang, Woo Suk Tae, Byung Joo Ham

Research output: Contribution to journalArticle

Abstract

Background: Although structural alterations have been reported in patients with major depressive disorder (MDD), very few studies have compared the shape alterations of the subcortical regions between drug-naïve MDD patients and healthy controls (HCs). Therefore, we investigated and compared the subcortical shape alterations and volumetric changes between drug-naïve MDD patients and HCs in this study. Methods: This study included 45 drug-naïve MDD patients and 83 HCs, who underwent three-dimensional (3-D) T1-weighted structural magnetic resonance imaging. Surface-based vertex analysis (SVA) was performed with automated segmentation of the bilateral caudate nuclei, putamina, nuclei accumbens, thalami, pallidum, hippocampi, amygdalae, and brainstem. SVA revealed regional contractions of the thalamus (bilateral medial and lateral nuclei) and right caudate nucleus (medial wall and anterosuperior areas) in the drug-naïve MDD patients when compared to HCs Results: In volume analysis, the drug-naïve MDD patients showed a significant decrease in the volume of bilateral thalami compared with HCs (after Bonferroni correction p < 0.003). We identified morphometric contractions in bilateral thalami and right caudate nucleus in the drug-naïve MDD patients (p < 0.05). Conclusions: The present study implied that with cortical shape changes, the subcortical brain alterations could contribute to emotional dysregulation in the drug-naïve MDD patients.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalJournal of Affective Disorders
Volume264
DOIs
Publication statusPublished - 2020 Mar 1

Fingerprint

Caudate Nucleus
Major Depressive Disorder
Thalamus
Pharmaceutical Preparations
Globus Pallidus
Nucleus Accumbens
Amygdala
Brain Stem
Hippocampus
Magnetic Resonance Imaging
Brain

Keywords

  • Caudate nucleus
  • Magnetic resonance imaging
  • Major depressive disorder
  • Subcortical region
  • Thalamus

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Comparison of shape alterations of the thalamus and caudate nucleus between drug-naïve major depressive disorder patients and healthy controls. / Choi, Kwan Woo; Han, Kyu Man; Kim, Hyun; Kim, Aram; Kang, Wooyoung; Kang, Youbin; Tae, Woo Suk; Ham, Byung Joo.

In: Journal of Affective Disorders, Vol. 264, 01.03.2020, p. 279-285.

Research output: Contribution to journalArticle

Choi, Kwan Woo ; Han, Kyu Man ; Kim, Hyun ; Kim, Aram ; Kang, Wooyoung ; Kang, Youbin ; Tae, Woo Suk ; Ham, Byung Joo. / Comparison of shape alterations of the thalamus and caudate nucleus between drug-naïve major depressive disorder patients and healthy controls. In: Journal of Affective Disorders. 2020 ; Vol. 264. pp. 279-285.
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AU - Tae, Woo Suk

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