Comparison of subchronic immunotoxicity of four different types of aluminum-based nanoparticles

Eun Jung Park, Sang Jin Lee, Gwang Hee Lee, Dong-Wan Kim, Cheolho Yoon, Byoung Seok Lee, Younghun Kim, Jaerak Chang, Kyuhong Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nanoparticles (NPs) have recently emerged as an inhalable pollutant, owing to their applications, aluminum-based NPs (Al-NPs) have been prioritized for toxicity testing. In the current study, we compared the pulmonary biopersistence and subsequent toxicity of four different types of Al-NPs (two rod-type aluminum oxide NPs [AlONPs] with different aspect ratios [short (S)- and long (L)-AlONPs], spherical aluminum cerium oxide NPs [AlCeO3, AlCeONPs] and spherical γ-aluminum oxide hydroxide nanoparticles [AlOOHNPs]) 13weeks after a single intratracheal instillation, considering the importance of their properties in their toxicity. We found that the pulmonary biopersistence of Al-NPs was strengthened by a high aspect ratio in the rod-type AlONPs and by the presence of hydroxyl groups in the spherical-type Al-NPs. The highest toxicity was observed in the mice treated with AlOOHNPs, which showed low biostability. More importantly, we identified that the commercially available AlCeONPs were Al2O3-coated CeO2 NPs, but not AlCeO3 NPs, although they have been sold under the trade name of AlCeONPs. In conclusion, the aspect ratio and biostability may be important factors in the determination of the biopersistence of NPs and the subsequent biological response. In addition, the physicochemical properties of NPs should be examined in detail before their release into the market to prevent unexpected adverse health effects.

Original languageEnglish
JournalJournal of Applied Toxicology
DOIs
Publication statusAccepted/In press - 2017 Jan 1

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Aluminum
Nanoparticles
Aluminum Oxide
Toxicity
Aspect ratio
Lung
Trademarks
Hydroxyl Radical
Names
Health

Keywords

  • Aluminum oxide nanoparticles
  • Biopersistence
  • Cerium oxide nanoparticles
  • Inflammation
  • Physicochemical properties

ASJC Scopus subject areas

  • Toxicology

Cite this

Comparison of subchronic immunotoxicity of four different types of aluminum-based nanoparticles. / Park, Eun Jung; Lee, Sang Jin; Lee, Gwang Hee; Kim, Dong-Wan; Yoon, Cheolho; Lee, Byoung Seok; Kim, Younghun; Chang, Jaerak; Lee, Kyuhong.

In: Journal of Applied Toxicology, 01.01.2017.

Research output: Contribution to journalArticle

Park, Eun Jung ; Lee, Sang Jin ; Lee, Gwang Hee ; Kim, Dong-Wan ; Yoon, Cheolho ; Lee, Byoung Seok ; Kim, Younghun ; Chang, Jaerak ; Lee, Kyuhong. / Comparison of subchronic immunotoxicity of four different types of aluminum-based nanoparticles. In: Journal of Applied Toxicology. 2017.
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