Comparison of the analgesic effect of ropivacaine with fentanyl and ropivacaine alone in continuous epidural infusion for acute herpes zoster management: A retrospective study

Hee Yong Kang, Chung Hun Lee, Sang Sik Choi, Mi Kyoung Lee, Yeon Joo Lee, Jong Sun Park

Research output: Contribution to journalArticle


Background and Objectives: Currently, few studies have reported the effects of opioids during continuous epidural infusion (CEI) to control pain owing to herpes zoster (HZ). This study aimed to retrospectively compare the effectiveness of epidural opioids in the treatment of acute HZ pain. Materials and Methods: We reviewed medical records of 105 patients who were divided into two groups: R group (CEI with ropivacaine) and RF group (CEI with ropivacaine and fentanyl). Clinical efficacy was evaluated using the numeric rating scale (NRS) score for 6 months after the procedures. We compared the percentage of patients with complete remission in each group. We investigated the complication rates during CEI. Results: No significant differences in the NRS scores were observed between the two groups in the 6-month period. The adjusted odds ratio (OR) for patients included in the complete remission was 0.6 times lower in the RF group than in the R group (95% confidence interval: 0.22–1.71, p = 0.35). The OR for complications during CEI was higher in the RF group than in the R group. However, the difference was not statistically significant. Conclusions: No difference was observed in the management of HZ pain and the prevention of postherpetic neuralgia between the two groups. The incidence of complications tended to be higher in the RF group than in the R group.

Original languageEnglish
Article number22
JournalMedicina (Lithuania)
Issue number1
Publication statusPublished - 2020 Jan



  • Continuous epidural infusion
  • Fentanyl
  • Herpes zoster
  • Intervention
  • Neuropathic pain
  • Postherpetic neuralgia
  • Ropivacaine

ASJC Scopus subject areas

  • Medicine(all)

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